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Glycosylated hemoglobin detection test paper and glycosylated hemoglobin detection method thereof

A technology for glycated hemoglobin and detection test paper, which is applied in the field of glycated hemoglobin detection, can solve the problems of high cost, complicated operation, poor precision and accuracy, and achieves the effects of low cost, high detection accuracy and control of dissolution speed.

Active Publication Date: 2020-08-11
杭州恒升医学科技有限公司
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Problems solved by technology

Among them, the HPLC method is widely used as the gold standard method for detecting glycosylated hemoglobin, but the cost is high; the precision and accuracy of the enzymatic method are poor; It is more accurate than enzymatic method, and its price is lower than that of HPLC method, but its operation is more complicated

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  • Glycosylated hemoglobin detection test paper and glycosylated hemoglobin detection method thereof
  • Glycosylated hemoglobin detection test paper and glycosylated hemoglobin detection method thereof
  • Glycosylated hemoglobin detection test paper and glycosylated hemoglobin detection method thereof

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Embodiment Construction

[0025] refer to Figure 1 to Figure 3 , a glycosylated hemoglobin detection test paper, comprising a bottom plate 1, a chromatographic membrane 2, a water-absorbent pad 3, a separator 4 and a cover plate 5, and the chromatographic membrane 2 and the water-absorbent pad 3 are respectively fixed on the left and right sides of the top surface of the bottom plate 1 , the top surface of the chromatographic membrane 2 is provided with an optical detection zone 21, and the optical detection zone 21 is provided with aminophenyl borate agarose bound to glycosylated hemoglobin, and the partition plate 4 is fixed on the chromatographic membrane 2 and the water-absorbent pad 3, one end of the separator 4 is provided with a hollow part 41 corresponding to the optical detection area 21, and the inner wall of the hollow part 41 is provided with a high polymer film 42 that seals and covers the optical detection area 21, so The high polymer film 42 can be dissolved by the eluent, and the top s...

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Abstract

The invention discloses glycosylated hemoglobin detection test paper and a method for detecting glycosylated hemoglobin by the glycosylated hemoglobin detection test paper. The glycosylated hemoglobindetection test paper comprises a bottom plate, a chromatographic film, a water absorption pad, a partition plate and a cover plate, the chromatography film and the water absorption pad are respectively fixed on the left side and the right side of the top surface of the bottom plate; an optical detection area is arranged on the top surface of the chromatography film; aminophenylboronic acid agarose combined with glycosylated hemoglobin is arranged on the optical detection area; the partition plate is fixed on the top surface of the chromatographic membrane; a hollow part corresponding to the optical detection area is arranged at one end of the partition plate; the inner wall of the hollow part is provided with a high polymer film for sealing and covering the optical detection area, the high polymer film can be dissolved by eluent, the top surface of the partition plate is further provided with a reaction area and an electrode group, and the method for detecting glycosylated hemoglobinby adopting the glycosylated hemoglobin detection test paper comprises the following steps: a) electrochemical detection; b) polymer film dissolution and c) photochemical detection, so that the detection accuracy is high, and the polymer film dissolution speed is controllable.

Description

【Technical field】 [0001] The invention relates to the technical field of glycosylated hemoglobin detection, in particular to the technical field of a test paper for glycosylated hemoglobin detection and a method for detecting glycosylated hemoglobin. 【Background technique】 [0002] Diabetes is a metabolic disease characterized by high blood sugar. The long-term high blood sugar in diabetic patients can easily lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels and nerves. [0003] Glycosylated hemoglobin (HbA1c) is the product of the combination of hemoglobin and blood sugar in red blood cells in the blood. Blood glucose enters the cells by diffusion without the participation of insulin. The combination process of blood sugar and hemoglobin is slow and irreversible, and it exists until the death of red blood cells. Therefore, the content of glycated hemoglobin in aging red blood cells in the body is about 1.5 times ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/72G01N27/26G01N21/75
CPCG01N33/723G01N27/26G01N21/75Y02A50/30
Inventor 张扬
Owner 杭州恒升医学科技有限公司
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