27 results about "Hemoglobin testing" patented technology

The invention relates to the technical field of biomedical engineering, in particular to a household noninvasive anemia monitoring and early warning method and system in a chronic kidney disease scene. The system comprises hemoglobin detection equipment, a dialysis machine and processing equipment, physiological data of the chronic kidney disease are collected through the hemoglobin detection equipment, dialysis is conducted on the chronic kidney disease through the dialysis machine, and dialysis data are recorded; and determining a predicted anemia risk grade of the chronic kidney patient through the processing equipment according to the physiological data, the dialysis data and the physical sign data of the chronic kidney patient, and performing anemia early warning according to the predicted anemia risk grade and the physiological data. According to the application, anemia home monitoring of the chronic kidney disease patient is realized, the patient does not need to go back to a hospital regularly, the economic burden and the body burden of the chronic kidney disease patient are reduced, and the life quality of the chronic kidney disease patient is remarkably improved.

The invention discloses an AI intelligent multi-terminal adaptive non-invasive hemoglobin detector and a detection method, and the detector comprises a configuration module which is used for transmitting combined light with a specific wavelength to penetrate a fingernail bed of a user when the fingertip of the user is placed in an accommodation cavity; the image acquisition module is integrated in the intelligent terminal and is used for shooting a multiband image reflected by a fingernail bed when the fingertip of the user is placed in the accommodating cavity; the transmission module is used for transmitting the multiband image to the processing module; and the processing module is internally provided with a deep learning spectral feature regression model and is used for extracting features related to the hemoglobin concentration from the multiband image, carrying out regression calculation and outputting a quantitative hemoglobin concentration value. Optical signals carry complete concentration related information after penetrating through the fingernail bed, so that the detection precision is improved; image acquisition is integrated on an intelligent terminal commonly used by a user, the use threshold is reduced through multi-terminal adaptation, the accuracy of data feature extraction is improved based on a deep learning spectral feature regression model, and then the accuracy of a detection result is improved.

The utility model relates to the technical field of medical detection devices, and discloses a glycosylated hemoglobin detection device, which comprises a sampling mechanism, a detection mechanism and a control mechanism, the sampling mechanism comprises an injection pump set, a sampling needle and a sampling valve, the sampling valve is a six-way sampling valve, the injection pump set is connected with a first port of the sampling valve, and the sampling needle is connected with a second port of the sampling valve; the separation mechanism comprises an eluent group, a mixer and a chromatographic separator, the eluent group is connected with a fifth port of the sample injection valve, the chromatographic separator is connected with a sixth port of the sample injection valve, and two ends of the mixer are connected with a third port and a fourth port of the sample injection valve; the inspection mechanism comprises a filter and an inspector, the filter is arranged between the mixer and the chromatographic separator, and the inspector is connected with the chromatographic separator. According to the utility model, the glycosylated hemoglobin can be rapidly and accurately detected through an accurate sample introduction and separation mechanism, so that the detection efficiency is improved. The automation degree of the detection process is high, the requirement for manual operation is reduced, and the possibility of human errors is reduced.

The present application relates to a non-invasive hemoglobin detection method based on hyperspectral image reconstruction, belonging to the field of physiological signal detection. The present application irradiates human skin tissue by using a visible light source, simultaneously uses a hyperspectral camera and an RGB camera to simultaneously collect images of the irradiated skin area as a training set, trains a deep learning model, and realizes hyperspectral reconstruction of ordinary RGB images. A hemoglobin extraction feature extraction model for the visible light range diffuse reflectance spectrum is established using an algorithm, and the real hemoglobin content of the measured human body is output through a hemoglobin correction model.

The application relates to a biochemical analyzer and a detection method for detecting glycated hemoglobin. The hemoglobin concentration and the glycated hemoglobin concentration of a to-be-detected whole blood sample are obtained, and the content proportion of the glycated hemoglobin is calculated according to the hemoglobin concentration and the glycated hemoglobin concentration. The hemoglobin concentration is obtained by the following steps: obtaining a first absorbance of a to-be-detected sample liquid at a hemoglobin measurement wavelength, wherein the to-be-detected sample liquid is prepared by mixing a to-be-detected whole blood sample, a hemolytic agent and a hemoglobin detection reagent; obtaining at least two second absorbances of the to-be-detected sample liquid at at least two different correction wavelengths, wherein the correction wavelengths are designed so that the absorbance of a lipid interferent at the correction wavelength is greater than the absorbance of hemoglobin at the correction wavelength; correcting the first absorbance according to the second absorbance; and determining the hemoglobin concentration according to the corrected first absorbance. The application can improve the accuracy of hemoglobin detection.

The system comprises a laminated 5 diagnostic strip including a backing layer (105), an absorbent pad layer (106) configured for controlled capillary transport of milk, and a reagent deposit layer (107) defining multiple spatially separated dry reagent zones. The reagent zones include a pH indicator zone (101), a leukocyte esterase detection zone (102), a hemoglobin detection zone (103), and a nitrite detection zone (104), each adapted 10 for operation in the milk matrix. A calibrated sample application point (108) receives a predefined volume of untreated milk and fluidically communicates the sample to the reagent zones via the absorbent pad layer. Colorimetric reactions develop in a result window area (109), enabling simultaneous visual interpretation without analytical instruments, typically within three minutes. The invention further 15 includes a moisture-controlled storage container comprising desiccant elements (204, 205), a reference color chart (208), and a calibrated pipette (209), ensuring reagent stability and standardized use.

A blood analyzer and a hemoglobin detection method, the method comprising: a control device controls a sampling device (11) to obtain a sample to be tested (201); a control device controls a sample preparation device (12) to mix a portion of the sample to be tested with a first reagent to prepare a first sample liquid to be tested, and a control device controls a portion of the sample to be tested with a second reagent to prepare a second sample liquid to be tested (202); a control device controls a colorimetric detection device (13) to perform a hemoglobin detection on the first sample liquid to be tested using a colorimetric method to obtain a first measurement value (203); a control device controls an optical detection device (14) to perform a hemoglobin detection on the second sample liquid to be tested using a light scattering method to obtain a second measurement value (204); and a control device determines whether the sample to be tested is a sample with a falsely high hemoglobin level (205); if the sample to be tested is a sample with a falsely high hemoglobin level, the control device outputs a second measurement value (206); if the sample to be tested is a sample with a falsely high hemoglobin level, the control device outputs a first measurement value (207).

The utility model discloses a high-precision glycosylated hemoglobin detection kit, which relates to the technical field of glycosylated hemoglobin detection kits, and comprises a kit body, a detection reagent bottle, a hemolytic reagent bottle and a sampling dropper are placed in the kit body, a dropper cover is clamped at an opening at one end of the hemolytic reagent bottle, and the sampling dropper is clamped at the other end of the hemolytic reagent bottle. One side, close to the hemolytic reagent bottle, of the dropper cover is fixedly connected with a sealing conical plug; the hemolytic reagent bottle is connected with the dropper cover in a clamped mode, one-hand operation can be achieved, the hemolytic reagent bottle can be opened and closed, work efficiency is improved, the sealing conical plug can be tightly attached to a bottle opening of the hemolytic reagent bottle, hemolytic reagent leakage is prevented, the risk that a reagent is polluted is reduced, and when a blood sample and a detection reagent are mixed, the hemolytic reagent bottle is not damaged. The mixing dropper can accurately control the output quantity of a treated blood sample, and meanwhile, the sample is prevented from splashing out due to too fast flowing, so that errors possibly generated in an intermediate link are reduced.

The invention relates to the technical field of glycosylated hemoglobin detection, in particular to a glycosylated hemoglobin detection method based on magnetic bead affinity adsorption, which comprises the following steps: A, sample pretreatment; b, total hemoglobin detection: detecting the absorbance H1 of the sample after hemolysis; c, carrying out affinity reaction; d, magnetic separation: starting an electromagnet tightly attached to the wall of the cuvette, and adsorbing the functionalized magnetic beads to the wall of the cuvette by adopting the electromagnet; e, non-glycosylated hemoglobin detection: detecting the absorbance H2 of the supernatant under the same optical path; and F, result calculation: calculating according to a formula HbA1c% = (H1-H2) / H1 * 100% to obtain a detection value of glycosylated hemoglobin. The glycosylated hemoglobin detection method disclosed by the invention is simple and convenient to operate, low in cost and very easy to realize automation. Compared with other high performance liquid chromatography methods for detecting glycosylated hemoglobin, the cost of a detection instrument is reduced by 70%, and the cost of a single test reagent is reduced by 30%.

A method for immunological detection of hemoglobin, the method comprising a step for performing immunological detection using an anti-hemoglobin antibody in the presence of hemoglobin and haptoglobin, the haptoglobin having the following characteristics (1): (1) at least a portion of an N-linked sugar chain is deleted. The present invention further provides a method for suppressing fluctuations in the detection value of hemoglobin, a method and a solution for stabilizing hemoglobin, a kit for detecting hemoglobin, and the haptoglobin and a method for producing the haptoglobin. According to the present invention, it is possible to detect hemoglobin by suppressing fluctuations in the detection value of hemoglobin due to haptoglobin.

The invention relates to a photoelectric detection system and method for hemoglobin detection, and relates to the technical field of spectral analysis and biomedical engineering. The method mainly comprises the following steps: controlling a light source module in the buckle type shell structure to emit light with different wavelengths, and enabling the light to penetrate through a blood transfusion tube and blood placed in the buckle type shell structure; a photoelectric detector module in the buckle type shell structure is controlled to obtain the blood transmission light intensity of the multi-wavelength light to the blood transfusion tube; calculating basic absorbance corresponding to the first wavelength and the second wavelength by using a hemoglobin absorption model, and correcting the basic absorbance by using a correction model to obtain final absorbance; according to the final absorbance corresponding to the first wavelength and the final absorbance corresponding to the second wavelength and the effective optical path length, predicting the concentration of deoxyhemoglobin and the concentration of oxyhemoglobin; and adding the deoxyhemoglobin concentration and the oxyhemoglobin concentration to obtain the total hemoglobin concentration.

The present invention is applicable to the field of medical equipment, and discloses a cell analyzer and a detection method for the cell analyzer. The cell analyzer includes a sampling component, an optical channel reaction pool, an optical detection unit, a hemoglobin detection unit, an impedance counting detection unit, a first reagent providing device, a second reagent providing device, a diluent providing device, a conveying pipeline assembly and a fluid power device. The fluid power device includes a first syringe and a second syringe. The range of the first syringe is smaller than the range of the second syringe. The second syringe is used to drive the optical detection sample from the optical channel reaction pool to the optical sample preparation pipeline. The first syringe is used to provide power for sample aspiration, sample separation and sample pushing. The second syringe is used to provide power for diluent delivery to the flow chamber, diluent delivery to the hemoglobin detection unit, diluent delivery to the impedance counting detection unit and sample preparation. The present invention greatly reduces the cost and volume of the instrument.

The present application relates to the field of biomedical engineering technology, and in particular to a method and system for non-invasive home anemia monitoring and early warning in the context of chronic kidney disease. The system includes a hemoglobin detection device, a dialysis machine, and a processing device. The physiological data of chronic kidney patients are collected by the hemoglobin detection device, the chronic kidney patients are dialyzed and the dialysis data are recorded by the dialysis machine, and the predicted anemia risk level of the chronic kidney patients is determined by the processing device based on the physiological data, dialysis data, and vital signs of the chronic kidney patients, and anemia early warning is performed based on the predicted anemia risk level and physiological data. The present application realizes home monitoring of anemia in chronic kidney patients without the need for them to travel back and forth to the hospital regularly, which reduces the economic and physical burden of chronic kidney patients and significantly improves the quality of life of chronic kidney patients.

The application relates to a sample analyzer and a sample analysis method. The sample analyzer comprises: a sample preparation device configured to prepare a pretreatment test solution by using a blood sample and a pretreatment reagent, prepare an interferent detection test solution by using the pretreatment test solution and a first detection reagent, and prepare a to-be-tested sample solution by using the pretreatment test solution or the interferent detection test solution and a second detection reagent; a first detection device configured to detect the interferent detection test solution to obtain interferent information; a second detection device configured to detect the to-be-tested sample solution to obtain a hemoglobin detection result and / or a glycated hemoglobin detection result of the blood sample; and a controller configured to output prompt information when the interferent information indicates that there is an interferent in the blood sample which interferes with the hemoglobin detection and / or the glycated hemoglobin detection. The embodiments of the application can detect the interferent and output corresponding interferent prompt information when the hemoglobin and / or the glycated hemoglobin is detected.

The present invention is applicable to the field of medical equipment and discloses a blood cell analyzer, which includes a sampling component, an optical channel reaction pool, an optical detection unit, a hemoglobin detection unit, an impedance counting detection sample preparation unit, an impedance counting detection unit, a first reagent providing device, a second reagent providing device, a diluent providing device, a conveying pipeline assembly and a fluid power device. The sampling component, the optical detection unit, the optical channel reaction pool, the hemoglobin detection unit, the impedance counting detection sample preparation unit, the impedance counting detection unit, the first reagent providing device, the second reagent providing device, the diluent providing device and the fluid power device are connected through the conveying pipeline assembly to form a liquid circuit system. During a detection cycle of completing hemoglobin detection, impedance counting detection and optical detection, the average gas consumption of the liquid circuit system is less than or equal to 2.0 L / min, thereby achieving miniaturization and low-cost design of the instrument.

The invention relates to the technical field of glycosylated hemoglobin detection, and discloses a biological sample treating fluid, a glycosylated hemoglobin detection kit and a glycosylated hemoglobin detection method. The biological sample treating fluid contains a reagent R1 and a reagent R2, wherein the reagent R1 contains latex microspheres and a buffer solution A; the reagent R2 contains a poly glycosylated hemoglobin monoclonal antibody, a buffer solution B and a surfactant; the surfaces of the latex microspheres have sulfate ions. The glycosylated hemoglobin detection kit contains the biological sample treatment liquid. The biological sample treating fluid has the advantages of high antibody stability, high detection result accuracy, high sensitivity, simple operation process and low production cost.

The present application relates to a kind of non-invasive hemoglobin detection methods based on atlas combination, belong to physiological signal detection field.The present application is by using white light source to irradiate the skin area (finger) containing human body, simultaneously using hyperspectral camera and industrial camera simultaneously to the image acquisition of skin area, by training spectral super-resolution model, realize hyperspectral reconstruction, then to hyperspectral data de-redundancy while retaining the features of image spatial information and spectral information, further according to the result of Monte Carlo simulation determines the channel attention module for specific wave band, finally establishes regression prediction model and predicts human hemoglobin concentration.

The present application relates to a kind of peritoneal cavity drainage liquid hemoglobin detection device;The device includes test module and connecting module:The connecting module is used to set the test module on drainage tube;The test module includes probe and processor;The probe is used to emit infrared light by emission end, after the reflection light of drainage liquid is received by receiving end, and send to the processor for hemoglobin detection;The processor is used to carry out variant component analysis based on the spectrum of the reflection light, constructs hemoglobin concentration regression model based on the light absorption contribution of the variant component, and obtains hemoglobin concentration by solving.This application solves the problem that there is no device for real-time detection of peritoneal cavity drainage liquid in the prior art, and only by observing the state of drainage liquid or the method of venous blood inspection can determine whether peritoneal cavity hemorrhage occurs.

The invention relates to the technical field of biomedical detection, and discloses hemoglobin detection test paper and application thereof.The hemoglobin detection test paper comprises a paper-based chip, and the paper-based chip is formed by soaking a paper base in a mixed solution composed of TMB, DIP and a buffer system and then drying the paper base; the concentration of DIP in the mixed solution is 25-35 mM, the concentration of TMB is 30-37.5 mM, and the buffer system is an acetic acid-sodium acetate buffer system. Compared with the prior art that when hemoglobin in a sample is detected, operation is complex, and cost is high, the scheme combines the high-precision analysis capacity of machine learning and the convenience of paper-based detection, and the method has the advantages of being easy and convenient to operate, low in cost, high in portability and the like, is suitable for being used by primary medical institutions and families, and has wide application prospects. The early diagnosis rate of local or systemic diseases (such as periodontitis) can be effectively improved, and powerful support is provided for early intervention and treatment of the diseases.

The invention discloses a monoclonal antibody for glycosylated hemoglobin detection, a preparation method thereof and a kit. The preparation method comprises the following steps: preparing complete antigens of saccharified hemoglobin and non-saccharified hemoglobin, respectively immunizing mice, and obtaining a hybridoma cell bank through cell electrofusion and HAT screening; screening three monoclonal antibodies by using an ELISA plate coated with HbA0-BSA and HbA1c-BSA through an enzyme-linked immunosorbent assay, wherein the three monoclonal antibodies comprise a first monoclonal antibody for specifically recognizing a covalent binding region of valine and saccharides at the N end of a hemoglobin beta chain and a second monoclonal antibody for specifically recognizing 1-6 amino acid regions at the N end of an unglycosylated hemoglobin beta chain; and a third monoclonal antibody that recognizes a hemoglobin alpha chain epitope. The kit comprises the antibody, and the percentage of the glycosylated hemoglobin is calculated by respectively detecting the concentration of the glycosylated hemoglobin and the concentration of the non-glycosylated hemoglobin by adopting a magnetic particle chemiluminescence method. The antibody is good in specificity and high in affinity, and the kit is high in hemoglobin variant recognition capacity and suitable for diabetes diagnosis and blood glucose monitoring in hospitals of all levels.

To provide assays and genotyping methods for the detection of hemoglobin A (HBA). [Solution] This disclosure relates to a hemoglobin A (HBA) assay and an HBA genotype determination tree matrix for implementation in clinical trials. More specifically, the embodiments relate to obtaining raw data from an HBA assay performed on multiple samples, calculating a first set of probe ratios for each sample based on the raw data, identifying the number of reference samples to be combined as a synthetic reference sample based on the first set of probe ratios, calculating a second set of probe ratios for each of the multiple samples based on the raw data and the synthetic reference samples, and determining the HBA genotype of each sample by a decision tree matrix based on the second set of probe ratios for each sample and the copy number call threshold of the sample probe / reference probe ratio associated with each probe of the multiple probes.

The invention provides an anemia detection device and an anemia detection model training method and device, and relates to the technical field of medical auxiliary equipment and the technical field of image processing, and the anemia detection device comprises an acquisition module which is used for acquiring a face image of a target user; the identification module is used for identifying a region of interest of a target image in the face image to obtain a region of interest image, and the region of interest is a lip region, a cheek region, a lip and cheek region or a full face region; and the detection module is used for performing anemia detection on the image of the region of interest through a pre-trained anemia detection model to obtain an anemia detection result corresponding to the target user, and the anemia detection result is a three-classification anemia degree detection result and / or a hemoglobin detection result. According to the invention, accurate grading of anemia severity and more accurate quantification of hemoglobin detection results are realized, and a more accurate basis is provided for differentiated treatment and clinical decision.

The glycosylated hemoglobin detection analyzer is characterized in that the glycosylated hemoglobin detection analyzer comprises a detection equipment structure and a detection groove structure arranged on the surface of the detection equipment structure, a portable structure is spirally installed on the surface of the detection equipment structure, and a dustproof cover structure is movably installed on the surface of the detection equipment structure; the detection groove structure comprises a detection cabin, a limiting strip, a spring, a clamping strip, a detection hole and a magnetic strip, according to the glycosylated hemoglobin detection analyzer disclosed by the invention, the detection groove structure is arranged, so that the detection plate which is centrally placed on the surface of the detection hole can be clamped and fixed, the displacement of the detection plate is effectively prevented, the stability during detection is ensured, and the detection efficiency is improved. By arranging the portable structure, the device is more portable in the moving process, an additional grip is provided for the device, the situation that the handheld device slips off and is damaged is avoided, meanwhile, the structure can be rapidly detached, and storage of the device is not affected.

The invention relates to a peritoneal drainage liquid hemoglobin detection device. The device comprises a test module and a connection module, wherein the connection module is used for arranging the test module on a drainage tube; the test module comprises a probe and a processor; the probe is used for emitting infrared light through the emitting end, receiving reflected light passing through drainage liquid through the receiving end and sending the reflected light to the processor for hemoglobin detection; and the processor is used for performing variation component analysis based on the spectrum of the reflected light, constructing a hemoglobin concentration regression model based on the light absorption contribution of the variation component, and resolving to obtain the hemoglobin concentration. The problem that in the prior art, a device for detecting peritoneal drainage liquid in real time is lacked, and whether peritoneal bleeding occurs or not can be judged only by observing the state of the drainage liquid or sending venous blood for inspection is solved.

The invention relates to the field of glycosylated hemoglobin detection, in particular to a hemolytic agent for detecting glycosylated hemoglobin through high performance liquid chromatography, a detection method and a system. The hemolytic agent comprises a polyoxyethylene ether nonionic surfactant, an organic alcohol preservative and a buffering agent, but does not comprise an ionic surfactant, under the synergistic effect of the polyoxyethylene ether nonionic surfactant and the organic alcohol preservative, the stability of a pre-diluted sample can be improved to 24 h or above, and the stability of the pre-diluted sample can be improved to 24 h or above. And accurate measurement of the pre-diluted sample after long-time storage is facilitated.

This specimen measurement device for measuring a blood specimen collected from a subject includes: an electrical detection unit (120) for detecting an electrical signal corresponding to a cell; an optical detection unit (110) for detecting an optical signal corresponding to the cell; a hemoglobin detection unit (130) for detecting an optical signal corresponding to a blood pigment; a preparation unit (162); and an analysis unit for analyzing measurement data and providing an analysis result. The preparation unit (162) prepares a measurement sample PAB for detecting platelet aggregation by the optical detection unit (110) in accordance with a measurement order including a measurement instruction for a measurement item CBC or measurement items CBC and DIFF. The analysis unit analyzes measurement data obtained by measuring the measurement sample PAB, and provides an analysis result relating to platelet aggregation.

The invention discloses a method for simultaneously detecting various hemoglobin in vitro and application thereof. The method comprises the following steps: (1) preparing a detection test strip; (2) dropwise adding human whole blood or a whole blood diluted sample on the reaction pad of the test strip; and (3) dropwise adding a sample flushing fluid on the flushing pad of the test strip, enabling the sample flushing fluid to sequentially flow to the absorption pad along the marking pad, the cracking pad and the reaction pad of the test strip, and after 4-6 minutes of complete reaction, interpreting a detection result according to the color development states of a Ctl point and a plurality of detection points on the reaction pad. The invention provides a rapid, simple and low-cost hemoglobin detection method, can simultaneously detect various hemoglobin such as HbA, HbS and HbC, and is suitable for rapid screening and clinical diagnosis of abnormal hemoglobin diseases such as sickle cell anemia.