11 results about "Hemoglobin testing" patented technology

The invention discloses an AI intelligent multi-terminal adaptive non-invasive hemoglobin detector and a detection method, and the detector comprises a configuration module which is used for transmitting combined light with a specific wavelength to penetrate a fingernail bed of a user when the fingertip of the user is placed in an accommodation cavity; the image acquisition module is integrated in the intelligent terminal and is used for shooting a multiband image reflected by a fingernail bed when the fingertip of the user is placed in the accommodating cavity; the transmission module is used for transmitting the multiband image to the processing module; and the processing module is internally provided with a deep learning spectral feature regression model and is used for extracting features related to the hemoglobin concentration from the multiband image, carrying out regression calculation and outputting a quantitative hemoglobin concentration value. Optical signals carry complete concentration related information after penetrating through the fingernail bed, so that the detection precision is improved; image acquisition is integrated on an intelligent terminal commonly used by a user, the use threshold is reduced through multi-terminal adaptation, the accuracy of data feature extraction is improved based on a deep learning spectral feature regression model, and then the accuracy of a detection result is improved.

The application relates to a biochemical analyzer and a detection method for detecting glycated hemoglobin. The hemoglobin concentration and the glycated hemoglobin concentration of a to-be-detected whole blood sample are obtained, and the content proportion of the glycated hemoglobin is calculated according to the hemoglobin concentration and the glycated hemoglobin concentration. The hemoglobin concentration is obtained by the following steps: obtaining a first absorbance of a to-be-detected sample liquid at a hemoglobin measurement wavelength, wherein the to-be-detected sample liquid is prepared by mixing a to-be-detected whole blood sample, a hemolytic agent and a hemoglobin detection reagent; obtaining at least two second absorbances of the to-be-detected sample liquid at at least two different correction wavelengths, wherein the correction wavelengths are designed so that the absorbance of a lipid interferent at the correction wavelength is greater than the absorbance of hemoglobin at the correction wavelength; correcting the first absorbance according to the second absorbance; and determining the hemoglobin concentration according to the corrected first absorbance. The application can improve the accuracy of hemoglobin detection.

The system comprises a laminated 5 diagnostic strip including a backing layer (105), an absorbent pad layer (106) configured for controlled capillary transport of milk, and a reagent deposit layer (107) defining multiple spatially separated dry reagent zones. The reagent zones include a pH indicator zone (101), a leukocyte esterase detection zone (102), a hemoglobin detection zone (103), and a nitrite detection zone (104), each adapted 10 for operation in the milk matrix. A calibrated sample application point (108) receives a predefined volume of untreated milk and fluidically communicates the sample to the reagent zones via the absorbent pad layer. Colorimetric reactions develop in a result window area (109), enabling simultaneous visual interpretation without analytical instruments, typically within three minutes. The invention further 15 includes a moisture-controlled storage container comprising desiccant elements (204, 205), a reference color chart (208), and a calibrated pipette (209), ensuring reagent stability and standardized use.

The invention relates to the technical field of glycosylated hemoglobin detection, in particular to a glycosylated hemoglobin detection method based on magnetic bead affinity adsorption, which comprises the following steps: A, sample pretreatment; b, total hemoglobin detection: detecting the absorbance H1 of the sample after hemolysis; c, carrying out affinity reaction; d, magnetic separation: starting an electromagnet tightly attached to the wall of the cuvette, and adsorbing the functionalized magnetic beads to the wall of the cuvette by adopting the electromagnet; e, non-glycosylated hemoglobin detection: detecting the absorbance H2 of the supernatant under the same optical path; and F, result calculation: calculating according to a formula HbA1c% = (H1-H2) / H1 * 100% to obtain a detection value of glycosylated hemoglobin. The glycosylated hemoglobin detection method disclosed by the invention is simple and convenient to operate, low in cost and very easy to realize automation. Compared with other high performance liquid chromatography methods for detecting glycosylated hemoglobin, the cost of a detection instrument is reduced by 70%, and the cost of a single test reagent is reduced by 30%.

The invention relates to the technical field of glycosylated hemoglobin detection, and discloses a biological sample treating fluid, a glycosylated hemoglobin detection kit and a glycosylated hemoglobin detection method. The biological sample treating fluid contains a reagent R1 and a reagent R2, wherein the reagent R1 contains latex microspheres and a buffer solution A; the reagent R2 contains a poly glycosylated hemoglobin monoclonal antibody, a buffer solution B and a surfactant; the surfaces of the latex microspheres have sulfate ions. The glycosylated hemoglobin detection kit contains the biological sample treatment liquid. The biological sample treating fluid has the advantages of high antibody stability, high detection result accuracy, high sensitivity, simple operation process and low production cost.

The present application relates to a kind of non-invasive hemoglobin detection methods based on atlas combination, belong to physiological signal detection field.The present application is by using white light source to irradiate the skin area (finger) containing human body, simultaneously using hyperspectral camera and industrial camera simultaneously to the image acquisition of skin area, by training spectral super-resolution model, realize hyperspectral reconstruction, then to hyperspectral data de-redundancy while retaining the features of image spatial information and spectral information, further according to the result of Monte Carlo simulation determines the channel attention module for specific wave band, finally establishes regression prediction model and predicts human hemoglobin concentration.

The invention discloses a monoclonal antibody for glycosylated hemoglobin detection, a preparation method thereof and a kit. The preparation method comprises the following steps: preparing complete antigens of saccharified hemoglobin and non-saccharified hemoglobin, respectively immunizing mice, and obtaining a hybridoma cell bank through cell electrofusion and HAT screening; screening three monoclonal antibodies by using an ELISA plate coated with HbA0-BSA and HbA1c-BSA through an enzyme-linked immunosorbent assay, wherein the three monoclonal antibodies comprise a first monoclonal antibody for specifically recognizing a covalent binding region of valine and saccharides at the N end of a hemoglobin beta chain and a second monoclonal antibody for specifically recognizing 1-6 amino acid regions at the N end of an unglycosylated hemoglobin beta chain; and a third monoclonal antibody that recognizes a hemoglobin alpha chain epitope. The kit comprises the antibody, and the percentage of the glycosylated hemoglobin is calculated by respectively detecting the concentration of the glycosylated hemoglobin and the concentration of the non-glycosylated hemoglobin by adopting a magnetic particle chemiluminescence method. The antibody is good in specificity and high in affinity, and the kit is high in hemoglobin variant recognition capacity and suitable for diabetes diagnosis and blood glucose monitoring in hospitals of all levels.

To provide assays and genotyping methods for the detection of hemoglobin A (HBA). [Solution] This disclosure relates to a hemoglobin A (HBA) assay and an HBA genotype determination tree matrix for implementation in clinical trials. More specifically, the embodiments relate to obtaining raw data from an HBA assay performed on multiple samples, calculating a first set of probe ratios for each sample based on the raw data, identifying the number of reference samples to be combined as a synthetic reference sample based on the first set of probe ratios, calculating a second set of probe ratios for each of the multiple samples based on the raw data and the synthetic reference samples, and determining the HBA genotype of each sample by a decision tree matrix based on the second set of probe ratios for each sample and the copy number call threshold of the sample probe / reference probe ratio associated with each probe of the multiple probes.

The invention provides an anemia detection device and an anemia detection model training method and device, and relates to the technical field of medical auxiliary equipment and the technical field of image processing, and the anemia detection device comprises an acquisition module which is used for acquiring a face image of a target user; the identification module is used for identifying a region of interest of a target image in the face image to obtain a region of interest image, and the region of interest is a lip region, a cheek region, a lip and cheek region or a full face region; and the detection module is used for performing anemia detection on the image of the region of interest through a pre-trained anemia detection model to obtain an anemia detection result corresponding to the target user, and the anemia detection result is a three-classification anemia degree detection result and / or a hemoglobin detection result. According to the invention, accurate grading of anemia severity and more accurate quantification of hemoglobin detection results are realized, and a more accurate basis is provided for differentiated treatment and clinical decision.

The invention relates to the field of glycosylated hemoglobin detection, in particular to a hemolytic agent for detecting glycosylated hemoglobin through high performance liquid chromatography, a detection method and a system. The hemolytic agent comprises a polyoxyethylene ether nonionic surfactant, an organic alcohol preservative and a buffering agent, but does not comprise an ionic surfactant, under the synergistic effect of the polyoxyethylene ether nonionic surfactant and the organic alcohol preservative, the stability of a pre-diluted sample can be improved to 24 h or above, and the stability of the pre-diluted sample can be improved to 24 h or above. And accurate measurement of the pre-diluted sample after long-time storage is facilitated.

This specimen measurement device for measuring a blood specimen collected from a subject includes: an electrical detection unit (120) for detecting an electrical signal corresponding to a cell; an optical detection unit (110) for detecting an optical signal corresponding to the cell; a hemoglobin detection unit (130) for detecting an optical signal corresponding to a blood pigment; a preparation unit (162); and an analysis unit for analyzing measurement data and providing an analysis result. The preparation unit (162) prepares a measurement sample PAB for detecting platelet aggregation by the optical detection unit (110) in accordance with a measurement order including a measurement instruction for a measurement item CBC or measurement items CBC and DIFF. The analysis unit analyzes measurement data obtained by measuring the measurement sample PAB, and provides an analysis result relating to platelet aggregation.