Opto-acoustic non-invasive hemoglobin detecting device and method capable of realizing temperature compensation

Abstract

The present invention discloses an opto-acoustic non-invasive hemoglobin detecting device and method capable of realizing temperature compensation and belongs to the technical field of non-invasive detection. According to the detecting method disclosed by the present invention, the concentration of hemoglobin is calculated by virtue of an ultrasonic signal generated by an interaction (an opto-acoustic effect) of multi-wavelength pulse laser and hemoglobin molecules in blood, rather than an optical signal, so that influences from scattered light are avoided, and the method may greatly reduce interference of human tissues and improve the sensitivity as comparison with an existing method; and due to the adoption of a temperature compensation method, the measurement precision is further improved. The device for realizing the detecting method in the present invention mainly includes a laser source module, an ultrasonic transducer, a signal processing circuit, a display, a microcontroller and a temperature sensor. The opto-acoustic non-invasive hemoglobin detecting device and method are suitable for screening the crowd with anemia.

Description

technical field [0001] The invention relates to a temperature-compensated photoacoustic non-invasive hemoglobin detection device and a detection method, belonging to the technical field of non-invasive detection. Background technique [0002] Hemoglobin is an important component of red blood cells in human blood, and its content index is an important basis for clinical diagnosis of anemia and other blood diseases. When the hemoglobin concentration level is lower than the normal value, it can be considered that the subject is suffering from anemia, and it may also be caused by massive blood loss, leukemia, postpartum, chemotherapy, hookworm disease, etc.; when the hemoglobin concentration is higher than the normal value, it also reflects Certain diseases of the human body, such as polycythemia vera, congenital heart disease, lung disease, and dehydration. Therefore, it is very important to detect the total hemoglobin concentration in human blood. [0003] Hemoglobin in huma...

AI Technical Summary

Problems solved by technology

The above method has the following disadvantages: it is necessary to collect blood samples from the subject, which is traumatic and painful, and may cause cross-contamination; the detection cycle is long, consumes medical equipment, and requires professional operation; continuous and real-time monitoring cannot be achieved. It is very inconvenient during dialysis, pregnant women's delivery and other operations

[0007] (1) The change of the light signal caused by the absorption of human tissue is very weak, and the change of the light signal caused by the absorption of hemoglobin molecules accounts for a small proportion of the overall light signal, so it is very difficult to extract the hemoglobin concentration data from the light signal;

[0008] (2) There is complex absorption and scattering of light in human tissue, which is subject to large tissue-specific interference between different individuals. To obtain higher measurement accuracy, it is necessary to calibrate for different individuals

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