Synthesis method and application of high-purity monobutyric acid glyceride

A technology of monobutyrin and synthesis method, which is applied in the field of synthesis of high-purity monobutyrin, and can solve the problem of low purity of monobutyrin

Inactive Publication Date: 2020-08-14
无锡利必多生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the shortcoming that the purity of the glyceryl monobutyrate obtained by the existing synthetic method is not high, the purpose of the present invention is to provide a kind of preparation method of the glyceryl monobutyrate with high purity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 1000g of glycerin and 1000g of butyric acid into the reaction vessel, and react for 6 hours at a temperature of 150°C. The content of glyceryl monobutyrate is 53.7%, and the content of glyceryl dibutyrate is 35.4%. Butyric acid The content is 9.9% (the composition does not include glycerol, the same below). Then the material temperature was lowered to 60°C, 2000g of water was added, 10g (about 50U / g reactant, the same below) of lipase TL100L (purchased from Novozymes) was added, and the reaction was stirred for 6 hours at 37°C Finally, the enzyme is filtered off, and molecular distillation (main parameters are: evaporation temperature is 140° C., vacuum degree is 100 Pa) removes residual water, butyric acid and glycerol to obtain high-purity monobutyrin. Through gas chromatographic analysis, the main component results are: the content of glyceryl monobutyrate is 90.1%, and the content of glyceryl dibutyrate is 9.5%. The acid value is 3.2 mgKOH / g.

Embodiment 2

[0026] Add 2000g of glycerin and 1000g of butyric acid into the reaction vessel, and react for 5 hours at a temperature of 160°C. The content of glyceryl monobutyrate and dibutyric acid as measured by gas chromatography is 55.6%, and the content of glyceryl dibutyrate is 35.7%. Butyric acid The content is 7.8%. Then the temperature of the material is reduced to 60°C, 3000g of water is added, 15g of lipase TL100L (purchased from Novozymes) is added, at 37°C, after stirring for 6 hours, the enzyme is filtered out, and the molecular distillation (main parameter is : Evaporating temperature is 140 ℃, vacuum degree is 100pa) take off remaining water, butyric acid and glycerin, namely obtain the monobutyrin of high purity. Through gas chromatography analysis, the main component results are: the content of glyceryl monobutyrate is 90.7%, and the content of glyceryl dibutyrate is 8.8%. The acid value is 3.8 mgKOH / g.

Embodiment 3

[0028] Add 3000g of glycerin and 1000g of butyric acid into the reaction vessel, and react for 4 hours at a temperature of 165°C. The content of glyceryl monobutyrate and dibutyric acid as measured by gas chromatography is 58.7%, and the content of glyceryl dibutyrate is 34.4%. Butyric acid The content is 6.0%. Then the temperature of the material is down to 60°C, add 3000g of water, add 15g of lipase PL20000L (purchased from Novozymes), at 37°C, stir and react for 5 hours, filter the enzyme, molecular distillation (main parameters are : Evaporating temperature is 140 ℃, vacuum degree is 100pa) take off remaining water, butyric acid and glycerin, namely obtain the monobutyrin of high purity. Through gas chromatographic analysis, the main component results are: the content of glyceryl monobutyrate is 91.7%, and the content of glyceryl dibutyrate is 8.0%. The acid value is 4.3 mgKOH / g.

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Abstract

The invention discloses a synthesis method and application of high-purity monobutyric acid glyceride. The method comprises the following steps: (1) conducting esterification reaction of butyric acid and glycerin; (2) reducing the temperature of the system to below 60 DEG C, adding water 0.2-5 times of the total product weight, then obtaining a reaction mixture, adding lipases, and conducting stirring for hydrolysis reaction, so as to reduce the proportion of dibutyrate glycerol ester to 5-15% of the total ester; and the lipases are Novozym435, TL-100L, and PL20000; and (3) removing the lipasesfrom the reactant, and obtaining the high-purity monobutyric acid glyceride by molecular distillation. According to the present invention, the synthesis of high-purity monobutyric acid glyceride, andthe monobutyric acid glyceride is applied in preparing feed additives.

Description

technical field [0001] The invention relates to a method for synthesizing high-purity monobutyrin. Background technique [0002] Glyceryl butyrate, composed of butyric acid molecules and glycerol through chemical bonds, is a colorless oily liquid with a slight special smell, and its structure is generally very stable. Glyceryl butyrate naturally exists in milk fat in a small amount. It is neutral in nature and stable in chemical properties. It can release butyric acid under the action of lipase. Butyric acid has powerful functions and plays a huge role in intestinal health. It can directly or indirectly participate in the repair and renewal of digestive tract tissues, and quickly provide energy for animal intestinal cells (especially cecum and colon cells). According to the different proportions of butyric acid on the glycerol chain, it can be divided into monobutyrin, dibutyrin and tributyrin. Butyrin has entered the field of animal health products because of its unique b...

Claims

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Application Information

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IPC IPC(8): C12P7/64A23K20/158A23K50/00A23K50/75A23K50/80
CPCA23K20/158A23K50/00A23K50/75A23K50/80C12P7/6454
Inventor 杨博刘峥陈华勇蓝东明田爱民曾煜辉
Owner 无锡利必多生物科技有限公司
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