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Application of cassia-twig rhizome-paridis resina-draconis extract in preparation of medicine for treating adenomyosis

The technology of Chonglou extract and adenomyosis, which is applied in the field of biomedicine, can solve the problems of low cure rate and the like, and achieve the effect of simple and easy preparation method.

Active Publication Date: 2020-08-25
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods for this disease include drug therapy and surgical intervention, but the cure rate is low, and the choice of clinical treatment options can only be individualized based on the patient's age, symptoms and fertility requirements

Method used

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  • Application of cassia-twig rhizome-paridis resina-draconis extract in preparation of medicine for treating adenomyosis
  • Application of cassia-twig rhizome-paridis resina-draconis extract in preparation of medicine for treating adenomyosis
  • Application of cassia-twig rhizome-paridis resina-draconis extract in preparation of medicine for treating adenomyosis

Examples

Experimental program
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Effect test

preparation example Construction

[0055] Preferably, the specific steps of the preparation method are as follows: place cassia twigs in the extraction kettle, use ethyl acetate as an entrainer, and introduce CO 2 extraction under conditions to obtain an extract; place the extract in a volatile oil extractor to continue micro-boiling extraction through steam distillation to obtain a brown-yellow volatile oil, that is, the cassia twig extract.

[0056] Further preferably, the cassia twig is extracted after being coarsely crushed; on the one hand, it is beneficial to the full dissolution of the volatile oil substances in the medicinal material;

[0057] Further preferably, the extraction temperature is 38-42°C.

[0058] Further preferably, the extraction pressure is 280-320 bar.

[0059] Further preferably, the extraction time is 1.8-2.2 hours.

[0060] Further preferably, the CO 2 The flow rate is 13-17ml / min.

[0061] Further preferably, the ethyl acetate is 0.22-0.28ml / min.

[0062] Further preferably, th...

Embodiment 1

[0097] Example 1 Preparation of Cassia Twig Extract and Its Intervention Effect on Adenomyosis Ectopic Lesion Cells

[0098] 1. Preparation of Cinnamon Twig Extract

[0099] The total volatile oil extract of cassia twig was prepared by supercritical fluid extraction-steam distillation technology. Specific process route: Take 2kg of cassia twigs, coarsely crush them, put them in a 10L extraction kettle, extract them at a pressure of 300bar, at an extraction temperature of 40°C, for a dynamic extraction time of 2h, in CO 2 The flow rate is 15ml / min, and the entrainer ethyl acetate is 0.25ml / min. Take the brownish-red liquid with strong fragrance obtained from the extraction, put it in a 500ml round bottom flask, use a volatile oil extractor to extract by steam distillation for 1 hour, and separate the brownish-yellow volatile oil (65ml) to obtain the total volatile oil extract of cassia twigs.

[0100] 2. Intervention effect of cassia twig extract on ectopic lesion cells of ad...

Embodiment 2

[0107] Example 2 Preparation of Chonglou Extract and Its Intervention Effect on Adenomyosis Ectopic Lesion Cells

[0108] 1. The preparation method of the extract of Chonglou

[0109] The extract of Chonglou was prepared by alcohol extraction, water sedimentation and high-speed centrifugation. The specific process route is as follows: take 2 kg of eucalyptus, grind it into the coarsest powder, add 6 times the amount of 70% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, and the filtrate decompresses to recover ethanol and concentrate to a relative density of about If the temperature is 1.10 (60°C), add 2 times the amount of water and stir well, let it stand for refrigerated (2-10°C) for 6 hours, centrifuge (6000r / min, 5min), take the precipitate, and dry the precipitate under reduced pressure (65-70°C, - 0.08Mpa), pulverized, that is.

[0110] 2. Intervention effect of Chonglou extract on ectopic focus cells of adenomyosis

...

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Abstract

The invention particularly relates to application of a cassia-twig rhizome-paridis resina-draconis extract in the preparation of a medicine for treating adenomyosis. In view of the current situation that no specific therapeutic medicine for the treatment of adenomyosis exists and the adenomyosis is relatively difficult to cure radically, extracts with anti- adenomyosis-activity are screened from the medicines commonly used clinically to promote blood circulation and remove blood stasis, soothe the liver and regulate qi, clarifying of the treatment mechanism of adenomyosis is facilitated, and corresponding medicines are provided for the treatment of clinical adenomyosis. The research of the invention respectively provides extracts of cassia twig, rhizoma paridis and resina draconis and combined extracts, and it is verified that the extracts have an inhibitory effect on cells of ectopic lesion of adenomyosis, and further, a mechanism of the extracts for inhibiting lesion tissues is further provided. The extracts of cassia twig, rhizoma paridis and resina draconis and the combined extracts are expected to become active ingredients for the treatment of clinical adenomyosis, and are ofgreat significance for the development of first-line therapeutic medicines.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of an extract of cassia twigs and rhizomes in the preparation of medicines for treating adenomyosis. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Adenomyosis is a diffuse or localized lesion in which endometrial glands and stroma invade the myometrium. Like endometriosis, it is a common and difficult disease in gynecology. Adenomyosis mostly occurs in multiparous women aged 30 to 50, but it can also be seen in young nulliparous women. This may be related to the increase in various uterine cavity operations, and its etiology is not completely ...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P15/00
CPCA61K36/54A61K36/896A61K36/889A61P15/00A61K2236/37A61K2236/333A61K2300/00
Inventor 师伟王信刘志勇徐丽李莉牛卫品
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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