Nano magnetic material for treating atherosclerosis and preparation method thereof

A nano-magnetic material and atherosclerosis technology, which is applied to the magnetism of organic materials/organic magnetic materials, preparations for in vivo tests, inductors/transformers/magnet manufacturing, etc., can solve the problem of single function and achieve good results Effect

Inactive Publication Date: 2020-08-28
NINGBO NOTTINGHAM NEW MATERIALS INST CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) There is currently no technology to reverse the formation of fatty, inflammatory coronary plaque
[0008] (2) Most technologies have the disadvantage of single function

Method used

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Experimental program
Comparison scheme
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Embodiment Construction

[0020] The specific embodiments of the present invention will be further described in detail below.

[0021] A kind of preparation method of the nanometer magnetic material that is used for the treatment of atherosclerosis that the present invention provides, utilizes corn stalks to synthesize superparamagnetic magnetite (Fe3O4) nanoparticle, and the concrete steps of this method are as follows:

[0022] (1) Corn stalks are cut into 1 cm long pieces, washed with tap water to remove pollutants, and then dried for 9 hours at a temperature of 75° C. to 82° C. in a vacuum drying oven. The Fe2O3 content of the corn stalks is: 15.39 wt%. The dried corn stover was stored at -12°C for future use.

[0023] (2) 200 grams of stored corn stalks were compacted to 300kg / m3 in a stainless steel reactor with a screw feeder, then degassed, injected with 2wt% sulfuric acid and stirred at 110°C for 5 hours. The solid-to-liquid ratio of corn stalks and sulfuric acid is 3:1 (w / w). After the rea...

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Abstract

The invention discloses a nano magnetic material for treating atherosclerosis, and a preparation method of the nano magnetic material. The preparation method comprises the following steps: preparing superparamagnetic nano Fe3O4 by utilizing a biomass material, wherein the surface is modified by ICG and polyethylene glycol; and injecting the prepared nano magnetic material into a human body, aiming, accumulating in lipid-rich coronary plaques, and irradiating local and far-end plaques with 808 nm laser to dissolve lipid. According to the invention, the nano magnetic material is used for fluorescence and magnetic resonance bimodal imaging diagnosis and near-infrared photothermal treatment of atherosclerosis; and the nano magnetic material and the preparation method thereof provided by the invention have a good application prospect, and the lipid is dissolved by using near-infrared heat treatment, so that the formation of the lipid is reversed, and the effect of treating atherosclerosis is good.

Description

technical field [0001] The invention relates to the field of preparation of nano magnetic materials, in particular to a nano magnetic material used for treating atherosclerosis and a preparation method thereof. Background technique [0002] Cardiovascular disease is the leading cause of morbidity and mortality in developed countries, and its morbidity and mortality are increasing with the development of aging population. The pathological basis of common cardiovascular diseases is atherosclerosis - a chronic inflammatory state that occurs in the walls of blood vessels. Atherosclerosis is caused by a mild form of inflammation that goes through different steps that eventually lead to the formation of atheromatous plaques on the walls of blood vessels. The formation of this plaque is associated with cholesterol and lipid deposition and infiltration of inflammatory cells, and mainly affects the vascular intima. Fatty coronary plaques are prone to rupture, and ruptured atheroscl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/42H01F41/02A61K49/12A61K49/00A61K41/00A61P9/10
CPCA61K41/0052A61K49/0002A61K49/0034A61K49/0054A61K49/126A61P9/10H01F1/42H01F41/02
Inventor 冯增兴吴韬李可张静汶夏娜闫誉馨马尼康
Owner NINGBO NOTTINGHAM NEW MATERIALS INST CO LTD
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