Application of CD40L nucleic acid aptamer in preparation of medicine for resisting aGVHD effect

A nucleic acid aptamer, 1. The technology of CD40L, applied in the field of biomedicine, can solve the problem of no CD40L nucleic acid aptamer and the like

Pending Publication Date: 2020-10-16
杨婷
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  • Application Information

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Problems solved by technology

But there is no relevant report that CD40L nucleic acid

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  • Application of CD40L nucleic acid aptamer in preparation of medicine for resisting aGVHD effect
  • Application of CD40L nucleic acid aptamer in preparation of medicine for resisting aGVHD effect
  • Application of CD40L nucleic acid aptamer in preparation of medicine for resisting aGVHD effect

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[0076] The principles and features of the present invention will be described below with reference to the specific drawings. The examples cited are only used to explain the present invention, and are not used to limit the scope of the present invention.

[0077] 1. Establish aGVHD mouse model of allogeneic hematopoietic stem cell transplantation

[0078] 1.1 Materials and methods

[0079] 1.1.1 Experimental animals

[0080] 21 BALB / C and C57bl / 6 pure mice each, male, 6-8 weeks old, weighing 18-22g, purchased from Shanghai Slack Laboratory Animal Co., Ltd., in the IVC System Animal Room of the Laboratory Animal Center of Fujian Medical University Raise SPF mice in the middle. All animal experiments strictly abide by the animal management and implementation regulations formulated by the Fujian Medical University Affiliated Union Hospital, Fujian Provincial Key Hematological Research Institute, and Fujian Hematological Research Institute Animal Ethics Committee. All experimental mice w...

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Abstract

The invention discloses application of a CD40L nucleic acid aptamer in preparation of a medicine for resisting an aGVHD effect, and belongs to the technical field of biomedicine. Tests show that the CD40L nucleic acid aptamer can circulate in a mouse body for a long time without influencing the survival of the mouse, the occurrence and development of aGVHD can be prevented, the hematopoietic reconstruction and immunity recovery of the transplanted mouse are promoted, and the immune reconstruction of the CD40L nucleic acid aptamer is superior to that of a clinical drug ATG. Therefore, the CD40Lnucleic acid aptamer can be used for preparing the medicine for resisting the aGVHD effect, a new application field of the CD40L nucleic acid aptamer is opened up, a new medicine for resisting the aGVHD effect is opened up, and the CD40L nucleic acid aptamer has wide application space.

Description

technical field [0001] The invention relates to the application of CD40L nucleic acid aptamer in the preparation of anti-aGVHD effect medicine, and belongs to the technical field of biomedicine. Background technique [0002] Allogeneic Hematopoietic Stem Cells Transplantation (allo-HSCT) is the most effective method to cure leukemia and other malignant blood diseases, severe aplastic anemia and hereditary blood diseases. At present, the most important factor restricting the efficacy of allo-HSCT is its postoperative complication, Graft Versus Host Disease (GVHD), which not only affects the survival after transplantation, but also seriously affects the quality of life of patients. Depending on the degree of human leukocyte antigen (Human Leukocyte Antigen, HLA) similarity and the source of the donor, about 30%-80% of recipients after transplantation will develop acute GVHD (Acute Graft Versus Host Disease, aGVHD); 30%-70% will survive Chronic GVHD (Chonic Graft Versus Host D...

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Application Information

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IPC IPC(8): A61K31/7088A61P37/06
CPCA61K31/7088A61P37/06
Inventor 杨婷胡建达骆晓峰任金华张钰鑫庄悠然朱浩杰吴雪琼陈秋茹曾雁玲肖敏陈少桢陈永铨林康昵陈敏敏李芊陈志哲
Owner 杨婷
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