41results about How to "Restore immunity" patented technology

The invention relates to a solid soluble propolis compound and relative preparation, wherein said invention is formed by packing anhydrous alcohol with beta- cyclodextrin (cyclodextrin or cyclodextrin derivant) to be extracted into propolis; it uses pastern bath to heat and remove wax, and uses anhydrous alcohol to extract the effective component of propolis, to be filtered, deposited, and vaporized into part alcohol dissolvent; then packing the cyclodextrin or cyclodextrin derivant, to be dried, broken and screened, to obtain the solid soluble propolis compound. The invention can effectively keep effect components of propolis, and the cyclodextrin can increase the solubility of effect components. The invention can be made into powder, sheet, drop, capsule and pastern, etc.

A method for overcoming immune suppression includes the steps of inducing production of naïve T cells and restoring T cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naïve T cells and exposing the naïve T cells to endogenous or exogenous antigens at an appropriate site. Additionally, a method for unblocking immunization at a regional lymph node includes the steps of promoting differentiation and maturation of immature dendritic cells at a regional lymph node and allowing presentation of processed peptides by resulting mature dendritic cells, thus, for example, exposing tumor peptides to T cells to gain immunization of the T cells. Further, a method of treating cancer and other persistent lesions includes the steps of administering an effective amount of a natural cytokine mixture as an adjuvant to endogenous or exogenous administered antigen to the cancer or other persistent lesions; preferably the natural cytokine mixture is administered in combination with thymosin α1.

A method for overcoming immune suppression includes the steps of inducing production of naïve T cells and restoring T cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naïve T cells and exposing the naïve T cells to endogenous or exogenous antigens at an appropriate site. Additionally, a method for unblocking immunization at a regional lymph node includes the steps of promoting differentiation and maturation of immature dendritic cells at a regional lymph node and allowing presentation of processed peptides by resulting mature dendritic cells, thus, for example, exposing tumor peptides to T cells to gain immunization of the T cells. Further, a method of treating cancer and other persistent lesions includes the steps of administering an effective amount of a natural cytokine mixture as an adjuvant to endogenous or exogenous administered antigen to the cancer or other persistent lesions; preferably the natural cytokine mixture is administered in combination with thymosin α1.

The invention relates to the field of care products, and in particular to functional female care wet tissue and a preparation method thereof. The functional female care wet tissue is made by injecting the following raw material components into hydroentangle non-woven fabrics: functional probiotics, propylene glycol, polyhexamethylene biguanidine hydrochloride, moisturizing curing agent, essential oil and purified water. The functional female care wet tissue provided by the invention is used for cleaning female pudendum, due to specific formula ratio, the functional probiotics are introduced, the long-term activity of the probiotics is maintained, growth and reproduction of escherichia coli, staphylococcus aureus and candida albicans at the female pudendum are effectively inhibited, and the micro-ecological environment of the pudendum is reestablished. The functional female care wet tissue has the effects of gentle cleaning and soft nourishing, and can inhibit harmful bacterium infection at the female pudendum. By adopting the female care wet tissue, harmful bacterium growth can be well inhibited, the situation of pruritus, inflammation and the like caused by harmful bacterium infection at the female private part is reduced, the health of the female pudendum and the genital tract is effectively maintained, and the wet tissue is free of irritation or sensitization and is safe and effective.

The invention discloses a facial cream for repairing cheek skin redness and preparation and application of the facial cream. The facial cream consists of the following raw materials in percentages bymass: a rhododendron ferrugineum extract, glycerinum, ectoine, superoxide dismutase, jojoba seed oil, oil of fruits of shorea robusta, sucrose palmitate, shea butter, glucan, sunflower seed oil, phytosterol, ceramide 1, ceramide 3, ceramide 6, squalane, polydimethylsiloxane, caprylic / capric triglyceride, Olivem 1000, polyglycerol-3 methyl glucose distearate, hydrogenated lecithin, cetostearyl alcohol, carbomer, xanthan gum, sodium hyaluronate, butanediol, rosa damascena flower water, panthenol, carnosine, ethoxydiglycol, a rhodiola rosea extract, chlorphenesin, caprylyl glycol, 1,2 pentanediol, perfluorodecalin, glycosphingolipid, sodium benzoate and water. The facial cream is used for repairing cheek skin redness for people in plateau areas.

The invention relates to the field of medicine and discloses application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and / or chemotherapy to treat tumors. The cordycepin has a structure shown in the following formula (1). The invention further discloses a pharmaceutical composition cooperating with radiotherapy and / or chemotherapy to treat tumors, wherein the pharmaceutical composition comprises active ingredients including the cordycepin and at least one of daunorubicin, dactinomycin and doxorubicin. The doxorubicin has high acting efficiency and low side effect in the application to the preparation of pharmaceuticals cooperating with radiotherapy and / or chemotherapy to treat tumors.

The invention discloses a nicotinamide mononucleotide and herbal extract microcapsule with limited component proportion. The capsule can maximize the immune resistance function. The preparation devicecomprises a container for accommodating nicotinamide mononucleotide, herbal active extract and an extraction solvent, and a return pipe, wherein the return pipe is provided with a feeding pipe, a delivery pipe and a connecting pipe; and a necking assembly is arranged in the connecting pipe. The device also comprises an ultrasonic assembly arranged in the connecting pipe, which can generate ultrasonic waves to quickly and uniformly mix the nicotinamide mononucleotide and herbal active extract in the mixed solution. The novel preparation process is utilized to uniformly fuse the herbal plant concentrated solution and excipient / emulsifier by a microencapsulation technique, thereby being different from the traditional excipient or emulsifier which is only coated on the outer layer, enhancingthe functional component proportion, lowering the excipient content and increasing the bioavailability requirements of the nicotinamide mononucleotide and herbal active extract.

The invention provides an application of inactivated probiotics in nursing products, a suspension and a probiotic non-woven fabric, which belong to the field of women's preventive nursing care products. A suspension, which is prepared by adding inactivated functional probiotics to purified water, mixing and stirring, and the mass percentage of the inactivated functional probiotics in the total mass of the suspension is 0.01%-2%. The suspension can effectively inhibit the growth of harmful bacteria and help the skin that has been infected by bacteria to restore immunity. The invention also provides a probiotic non-woven fabric, which is prepared by spraying the suspension on the non-woven fabric and drying it. Probiotic non-woven fabrics can effectively maintain women's private parts. In addition, the present invention also provides an application of inactivated probiotics in nursing products. After adding inactivated functional probiotics into purified water, mixing and stirring to form a suspension, the suspension is added to nursing products, and the nursing products Being able to directly contact and play a role in women's private parts is beneficial to women's health.

The invention discloses an extraction method of polysaccharide with activities of kidney warming and Yang tonifying from Aspongopus chinensis Dallas insects of Pentatomidae and application of the polysaccharide. The extraction method comprises the following steps: (1) drying Aspongopus chinensis Dallas insect bodies, performing pulverization, performing reflux extraction with petroleum ether, andconducting filtration liquid-solid separation so as to obtain drug residues with removal of grease; (2) evaporating the drug residues, performing reflux extraction with distilled water, performing filtration, combining the filtrate, and performing concentration so as to obtain total water extract; (3) adding distilled water to the total water extract for slight dilution, performing precipitation on polysaccharide with an alcohol solution, performing stirring while the alcohol solution is added, and performing still standing and filtration so as to obtain an insect polysaccharide alcohol precipitate; and (4) adding water to the insect polysaccharide alcohol precipitate for dilution and dissolution, performing chromatography separation and purification by using a DEAE-Sephadex ged cellulosecolumn, and performing rinsing with distilled water and a sodium chloride solution so as to obtain the Aspongopus chinensis Dallas polysaccharide. The invention also relates to the application of thepolysaccharide in preparation of drugs for treating or preventing Yang deficiency, impotence and erectile dysfunctions, the method is easy has simple and convenient operation, and the obtained polysaccharide compound with a purity of up to 95% has strong effects of kidney warming, Yang tonifying, fatigue resistance and body immunity recovery.

The invention provides a pharmaceutical composition for treating diabetes and a preparation method thereof, and relates to the technical field of medicines. The pharmaceutical composition for treating the diabetes comprises cereal dietary fibers, whey protein, milk powder, acerola cherries, Chinese wolfberry fruits, silybum marianum, a white kidney bean extract, chia seeds, psyllium seed husks, cordyceps militaris, cordyceps sinensis, oyster peptides, anoectochilus formosanus, lecithin, dendrobium officinale, selenium-enriched yeast powder, natto powder, vitamins, a sweetening agent, prebiotics and a calcium agent. Through mutual matching of specific components, the pharmaceutical composition can effectively control blood sugar and restore immunity. Moreover, all the components are medicinal and edible raw materials, so that the effects of purifying blood and reducing blood sugar can be achieved for patients through dietetic invigoration, and the pharmaceutical composition is green, safe and free of toxic and side effects, so that injury caused by abuse of medicines is effectively avoided.

The invention provides the application of active probiotics in nursing materials, suspension and probiotics non-woven fabric and belongs to the field of preventive nursing materials for women. The suspension is obtained by adding active functional probiotics to purified water and conducting mixing and stirring, and the mass of the active functional probiotics accounts for 0.01-2% of the total mass of the suspension. The suspension can effectively inhibit the growth of harmful germs, and can help skin infected with germs regain immunity. The invention further provides probiotics non-woven fabric. The probiotics non-woven fabric is obtained by spraying the suspension onto non-woven fabric and then conducting drying. The probiotics non-woven fabric can effectively nurse the private parts of women. The invention further provides the application of active probiotics in nursing materials. By adding the active functional probiotics to purified water and conducting mixing and stirring to generate the suspension and then spraying the suspension onto non-woven fabric and conducting drying, the nursing materials can make direct contact with the private parts of women and come into play, so that the health of women is guaranteed.

The invention discloses a portable multifunctional health-care mattress with easy collection, belonging to the field of furniture and solving the technical problems of single function and difficulty in carrying and collection of the mattress in the prior art. The mattress comprises an upper fabric layer, a composite-function fiber layer and a magnetic function layer from top to bottom, wherein organic germanium finishing agents are uniformly distributed on the surface of the upper fabric layer; the magnetic function layer comprises a layer of needle-punched nonwoven felt cloth; the upper side of the needle-punched nonwoven felt cloth is provided with at least one three-dimensional magnetic-field transmitting unit and at least one magnetic tape; and the three-dimensional magnetic-field transmitting unit and the magnetic tape are arranged in parallel. In the portable multifunctional health-care mattress, the composite-function fiber layer not only can transmit far infrared rays beneficial to a human body and generate negative ions, but also has multiple functions such as lasting bacterium resistance, natural health care and the like. In addition, the portable multifunctional health-care mattress also can generate a high-density and high-penetrating-power magnetic field, and acts on the cell metabolism of the human body continuously by physical energy of the magnetic field, thus adjusting and improving the organic functions continuously and further improving the sleeping quality.

The invention relates to health hawthorn wine. The health hawthorn wine is brewed from the following raw materials in parts by weight: 85-90 parts of ethanol water, 2-3 parts of hawthorns, 0.5-1 part of ginseng, 2-3 parts of wolfberry, 0.5-1 part of schisandra chinensis, 2-2.5 parts of lotus leaves, 1-1.5 parts of poria cocos and 2-3 parts of white sugar. Compared with the prior art, the health hawthorn wine has the effects of dispersing accumulation, relieving dyspepsia, astringing, stopping dysentery, activating blood and dispersing stagnation.

The invention discloses an isodon amethystoides extract for treating interstitial pneumonia and a preparation method of the isodon amethystoides extract, and belongs to the technical field of plant extraction. The preparation method comprises the following steps: (1) material selection: selecting whole grass of isodon amethystoides; (2) ultrafine grinding: carrying out ultrafine grinding on the whole grass of the isodon amethystoides; (3) extraction: putting isodon amethystoides powder into an extraction tank, adding water, carrying out cooking for three times, and carrying out extraction; (4)impurity removal: adding ethanol, and carrying out cleaning, so as to remove impurities; (5) reagent recycling: recycling ethanol in the step (4), waiting, and extracting supernatant from finished concentrated liquid; and (6) concentration drying: carrying out concentration drying on the supernatant, so as to obtain the isodon amethystoides extract. The isodon amethystoides extract is used for treating the interstitial pneumonia three times a day, the dose of the isodon amethystoides extract is 1.5g-2.6g each time, and the healing time is about 1 year and is shortened to be 1 / 6 of a traditional treatment time length, so that the time is saved.

The invention relates to a solid soluble propolis compound and relative preparation, wherein said invention is formed by packing anhydrous alcohol with beta- cyclodextrin (cyclodextrin or cyclodextrinderivant) to be extracted into propolis; it uses pastern bath to heat and remove wax, and uses anhydrous alcohol to extract the effective component of propolis, to be filtered, deposited, and vaporized into part alcohol dissolvent; then packing the cyclodextrin or cyclodextrin derivant, to be dried, broken and screened, to obtain the solid soluble propolis compound. The invention can effectivelykeep effect components of propolis, and the cyclodextrin can increase the solubility of effect components. The invention can be made into powder, sheet, drop, capsule and pastern, etc.

The invention discloses externally used paste for treating rheumatic and rheumatoid arthritis and its preparation method and use. The externally used paste comprises methyl glucse sesquistearate, pentaerythritol distearate, glyceryl stearate, shea butter, cyclomethicone, polydimethylsiloxane, cetearyl alcohol, tocopheryl acetate, bisabolol, methyl salicylate, disodium EDTA, allantoin, glycerinum, jojoba wax PEG-120 ester, sodium hyaluronate, carbomer, hydroxyethylurea, trehalose, beta-glucan, D-glucosamine hydrochloride, chondroitin sulfate, dimethyl sulfone, caprylic / capric triglyceride, capsaicin, a sodium acrylate / sodium acryloyldimethyl taurate copolymer, bis(hydroxymethyl)imidazolidinyl urea, essence and distilled water. The externally used paste has good treatment effects, lasting curative effects and no side effect.

Generation and identification of highly effective immune effector cell in terms of target cell-killing activity can be enhanced by optimizing the proximity between a target cell and the immune effector cell. The cancer-killing T cells described herein can provide highly effective therapies for diverse cancer types, e.g., solid cancers, hematological cancers, and metastatic forms thereof. Provided herein are ex-vivo methods of generating cancer-killing T cells, compositions comprising such immune cells; methods of using the cells, methods of selecting optimal agents for enhancing the target cell killing activity, methods of selecting an optimized immune cell and methods of using this approach to evaluate patient responsiveness to other cancer therapies.

The invention discloses a traditional Chinese medicinal ointment for treating body surface ulcer or skin damnify caused by various reasons and its preparing process, wherein the ointment comprises Chinese angelica root, notoginseng, goldthread root, dahurian angelica root, firewood, rhubarb horsetails, Cinnamomum cassia, scrophularia root, dried rehmannia root, buthus martensi kirsch, safflower and white pepper.

The invention provides a psychological massage health-caring sheet and a usage method thereof, which is invented by aiming at the phenomena that after people become adults, due to the dormancy of external tissue, the back bends and the waist aches, the psychological function is reduced and the organism natural immunity is lost; the massage health-caring sheet comprises a sheet body (1); the upper surface and the lower surface are provided with a fine sand layer (2) respectively; the fine sand layer (2) and the thin body (1) are fixed as a whole. The usage method of the invention comprises the steps as follows: the massage health-caring sheet is arranged inside nonnasality and supported by tongue body; the tongue body licks the maxillary, mandible, two cheeks, interior and exterior of gum, teeth and lips so as to activate the incretion of gland and leads the saliva to be filled in the mouth; Chinese shenshui, ichor, and the like are extracted. The psychological massage health-caring sheet and the usage method of the invention have the beneficial effects that the price is low, the usage is convenient, the effect is obvious and the generalization is convenient. The tongue body and the teeth in the nonnasality are used to develop the potential of the human body so as to change the natural growth rule of the human body and achieve the object of leading the dormancy tissue to be recovered, thus improving the organism of natural decay of human body, prompting the blood circulation, leading the blood to be smooth, recovering the natural immunity of the human body, improving the micro-circulation side the body and especially having obvious effects on black hair, teeth-caring, etc.

The invention relates to the technical field of medicine and pharmacy, in particular to polypeptide for selectively degrading PD-L1 protein on a tumor cell membrane and application. The polypeptide can be subjected to enzymatic in-situ self-assembly under the action of ALP overexpressed outside a tumor cell, and a DPPA-1 sequence capable of being specifically combined with PD-L1 exists in a polypeptide molecule, so that the self-assembled polypeptide nanofiber can be selectively combined with the PD-L1 on the tumor cell membrane to simulate a partial denaturation state of the PD-L1; and the PD-L1 protein is degraded through a proteasome way after being swallowed into cells, so that the PD-L1 protein on the tumor cell membrane is effectively degraded, the control of tumor cells on an immune system is relieved, and a new thought is provided for the preparation of tumor immunotherapy drugs.

The present invention provides multispecific polypeptides, such as bispecific antibodies, comprising a first binding domain capable of specifically binding to GITR, and a second binding domain capable of specifically binding to CTLA-4. The invention further provides compositions of said bispecific polypeptides, as well as methods and uses of the same.

The invention relates to the technical field of fluid magnetization, and particularly relates to a plasma magnetic field tube. The plasma magnetic field tube comprises a tube body, and magnetic energygenerating assemblies which are circumferentially arranged on the circumferential wall of the tube body, wherein a fluid channel is formed in the tube body; the diameter of a water inlet of the fluidchannel is beyond the diameter of a water outlet; uniformly-distributed spiral grooves are formed in the circumferential wall of the fluid channel; a plasma film coating layer is arranged on the inner circumferential wall of the fluid channel; the magnetic energy generating assemblies are used for generating magnetic fields in the tube body, and the magnetic fields are distributed in the direction vertical to the axial direction of the tube body; and the strength of the magnetic fields gradually changes from the water inlet end to the water outlet end. According to the plasma magnetic field tube, the tube body is arranged; the theories of the magnetic fields, plasma, zero point fields and vortex fields are utilized, and the fluid channel gradually narrows, and the magnetic fields gradually increase at the same time, so that the content of hydrogen ions and oxygen ions in water increases, and meanwhile, the energy of hydrogen ions and oxygen ions in water increases, and as a result, the water is further activated, and the water quality is greatly improved.

The invention discloses application of a CD40L nucleic acid aptamer in preparation of a medicine for resisting an aGVHD effect, and belongs to the technical field of biomedicine. Tests show that the CD40L nucleic acid aptamer can circulate in a mouse body for a long time without influencing the survival of the mouse, the occurrence and development of aGVHD can be prevented, the hematopoietic reconstruction and immunity recovery of the transplanted mouse are promoted, and the immune reconstruction of the CD40L nucleic acid aptamer is superior to that of a clinical drug ATG. Therefore, the CD40Lnucleic acid aptamer can be used for preparing the medicine for resisting the aGVHD effect, a new application field of the CD40L nucleic acid aptamer is opened up, a new medicine for resisting the aGVHD effect is opened up, and the CD40L nucleic acid aptamer has wide application space.

The invention discloses plant compound gelatin for privacy conservation of women and a preparation method of the plant compound gelatin for privacy conservation of women. The plant compound gelatin comprises 35-65 parts of a plant compound, 5-10 parts of a hydrating agent,10-15 parts of a PH regulating agent, and 10-50 parts of natural plant gelatin. The plant compound gelatin for privacy conservation of women provided by the invention is obtained by performing extracting on varied traditional Chinese medicines, performing compounding, and preforming extracting from pure plates. The plant compound gelatin for privacy conservation of women is free from chemical components, free from irritating, free from hormone and free from side effect, has the following advantages of being high in defensive power for promoting growth of probiotics, restraining harmful bacteria, and restoring immunity; self cleaning: replacing protein remaining, renewing old cells, and repairing a private self-cleaning system ; deep moistening: enabling plant essence to direcetly achieve the deep level of skin and muscle, stimulating cell viability and improving microcirculation; being high in repair: repairing and perfecting damaged mucosal cells, and enabling the skin and the muscle to naturally show buxom, moistening and elastic feeling; and performing high in balance: balancing endovaginal pH value and restoring endovaginal weak acid environment.

The invention belongs to the field of veterinary use medicine, and particularly relates to a veterinary use traditional Chinese immunopotentiator and application thereof. the veterinary use traditional Chinese immunopotentiator is prepared from the following raw materials in parts by weight: 7 to 14 parts of radix angelicae sinensis polysaccharide, 2 to 10 parts of mushroom polysaccharide, 3 to 8 parts of aloe polysaccharide, 10 to 30 parts of polyoxyethylene hydrogenated castor oil, 5 to 15 parts of absolute ethyl alcohol, 20 to 40 parts of ethyl acetate and 10 to 30 parts of water for injection. The veterinary use traditional Chinese immunopotentiator is applied to Newcastle disease inactivated vaccines (La Sota strains); the self immunopotentiation effect of the traditional Chinese medicine is achieved; the defects of conventional adjuvants can be avoided; the immune effect is obviously improved; safety, high efficiency and non-toxicity are realized; meanwhile, the veterinary use traditional Chinese immunopotentiator is prepared into nanoemulsion; the antigen slow release is realized; the immunization period of the vaccine is prolonged; and the vaccine quality is greatly improved.

The embodiment of the invention discloses an oral care composition and a preparation method thereof. An oral care composition includes cannabidiol and other cannabinoids; wherein the weight ratio of the cannabidiol to the other cannabinoids is (1-10): (1-10). According to the oral care composition provided by the invention, the components have a synergistic effect, so that the oral care composition has a remarkable effect on treating periodontitis, oral ulcer, gingivitis and ozostomia, and meanwhile, the oral care composition also can reconstruct immune system functions, recover immunity, thoroughly solve oral problems and reduce the recurrence rate. The mouthwash or oral liquid spray provided by the invention is convenient to use, safe, free of any side effect, suitable for long-term use and capable of meeting the requirements of clinical oral care.

The invention relates to the technical field of medicine and pharmacy, in particular to a polypeptide for selectively degrading PD-L1 protein on tumor cell membranes and its application. The polypeptide of the present invention can undergo enzymatic in situ self-assembly under the action of ALP overexpressed in tumor cells, and the polypeptide molecule has a molecule that can specifically bind to PD-L1. D The PPA-1 sequence enables the self-assembled polypeptide nanofibers to selectively bind to PD-L1 on the tumor cell membrane to simulate its partial denaturation state, and is then endocytosed into cells and degraded through the proteasome pathway, thereby effectively degrading The PD-L1 protein on the tumor cell membrane relieves the control of tumor cells on the immune system and provides new ideas for the preparation of tumor immunotherapy drugs.

The invention discloses traditional Chinese medicine composition for treating gastrointestinal bleeding. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 3-5 parts of alfalfa, 3-5 parts of amaranthus tricolor, 5-7 parts of radix astragali, 4-6 parts of elm bark, 2-4 parts of broadbean flower, 3-5 parts of fructus gardeniae, 4-6 parts of kalimeris indica, 5-7 parts of herba duchesnea indica, 6-8 parts of nodus nelumbinis rhizomatis, 3-5 parts of silene conoidea seedling, 5-7 parts of rhizoma imperatae, 2-4 parts of plant soot, 4-6 parts of equisetum ramosissimum and 5-7 parts of common sowthistle herb. The raw materials are put into a medicine decoction pot, boiled in water with high flame, decocted with low flame for 30-35 minutes and filtered, a filter liquor and filter residues are obtained, the filter liquor is taken, and water is added for soaking the filter residues; and at night, the raw materials are decocted and filtered again, filter residues are thrown away, and a filter liquor is taken. The traditional Chinese medicine composition has the effects of stopping bleeding by astringing, clearing heat, promoting diuresis, removing toxins and swelling, eliminating body nidi and improving body immunity; during treatment, the human body function is recovered, the human body immunity is improved and the body is assisted in tissue repair; and finally through body regulation, the purposes of treating both symptoms and root causes and curing and resisting diseases are achieved.