Extraction method of polysaccharide with activities of kidney warming and Yang tonifying from Aspongopus chinensis Dallas insects of Pentatomidae and application of polysaccharide
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A technology of aphrodisiac activity and extraction method, which is applied in the direction of diseases, allergic diseases, urinary system diseases, etc., can solve the problems of the influence of patient dependence, cure the symptoms but not the root cause, and short curative effect period, and achieve low cost, high cure rate, Excellent curative effect
Active Publication Date: 2019-01-29
HUBEI UNIV OF CHINESE MEDICINE
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The western medicine sildenafil or phentolamine on the market has a short curative effect, and long-term use has certain side effects.
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Embodiment 1
[0036] Experimental Materials
[0037] Hydrocortisone, Chengdu Aikeda Chemical Reagent Co., Ltd. (purity 98%); Dazhu Rhodiola Capsules, Jiangsu Kangyuan Pharmaceutical Co., Ltd.; Jinkuishenqi Pills, Beijing Tongrentang Science and Technology Development Co., Ltd. Pharmaceutical Factory ; Bujiale (estradiol valerate), Bayer Healthcare Co., Ltd.; physiological saline, Wuhan Binhu Double Crane Pharmaceutical Co., Ltd.; lactic acid test kit, urea nitrogen kit, Nanjing Jiancheng Bioengineering Research Institute. Female and male Kunming mice, weighing 18-22g, were purchased from the Hubei Provincial Experimental Animal Research Center; female and male SD rats, weighing 180-220g, were purchased from the Hubei Provincial Experimental Animal Research Center; ultrapure water: Water purifier laboratory Dedicated ultrapure water machine. Electronic analytical balance: Precisa, model: XB220A; refrigerated centrifuge: Eppendorf, Germany, model: Centrifuge 5804 R; microplate reader: Americ...
Embodiment 2
[0050] The application of a polysaccharide from the stinkbug family insects with the functions of warming the kidney and strengthening yang, resisting fatigue and restoring the body's immunity in the preparation of medicines for treating or preventing yang deficiency, impotence and erectile dysfunction comprises the following steps:
[0051] 1. The influence of blood lactic acid content
[0052] Male Kunming mice were randomly divided into 4 groups, with 10 animals in each group, respectively blank control group (normal saline), positive control group (Dazhu Rhodiola Capsules, 590mg / kg), low-dose groups of each extract (1.4 g / kg, based on the original medicinal material), the medium dose of each extract (7g / kg, based on the original medicinal material), and the high dose of each extract (14g / kg, based on the original medicinal material). Administer for 15 days. 30 minutes after the last administration, 20 μL of blood was collected from the inner canthus of the orbit. After swi...
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Abstract
The invention discloses an extraction method of polysaccharide with activities of kidney warming and Yang tonifying from Aspongopus chinensis Dallas insects of Pentatomidae and application of the polysaccharide. The extraction method comprises the following steps: (1) drying Aspongopus chinensis Dallas insect bodies, performing pulverization, performing reflux extraction with petroleum ether, andconducting filtration liquid-solid separation so as to obtain drug residues with removal of grease; (2) evaporating the drug residues, performing reflux extraction with distilled water, performing filtration, combining the filtrate, and performing concentration so as to obtain total water extract; (3) adding distilled water to the total water extract for slight dilution, performing precipitation on polysaccharide with an alcohol solution, performing stirring while the alcohol solution is added, and performing still standing and filtration so as to obtain an insect polysaccharide alcohol precipitate; and (4) adding water to the insect polysaccharide alcohol precipitate for dilution and dissolution, performing chromatography separation and purification by using a DEAE-Sephadex ged cellulosecolumn, and performing rinsing with distilled water and a sodium chloride solution so as to obtain the Aspongopus chinensis Dallas polysaccharide. The invention also relates to the application of thepolysaccharide in preparation of drugs for treating or preventing Yang deficiency, impotence and erectile dysfunctions, the method is easy has simple and convenient operation, and the obtained polysaccharide compound with a purity of up to 95% has strong effects of kidney warming, Yang tonifying, fatigue resistance and body immunity recovery.
Description
technical field [0001] The invention belongs to the technical field of polysaccharide extraction from stinkbug insects, and more specifically relates to a method for extracting polysaccharides from stinkbug insects with the activity of warming the kidney and strengthening yang, and also relates to a kind of stinkworm with the activity of warming the kidney and strengthening yang Uses of polysaccharides from Stink bugs. Background technique [0002] Erectile dysfunction is one of the most common sexual dysfunctions in men, and current research suggests that age is the strongest independent factor among risk factors for erectile dysfunction. Male erection is a complex process involving brain, hormones, emotions, nerves, muscles, blood vessels and many other issues. [0003] Asponpus chinensis Dallas is the dried body of Aspongopus chinensis Dallas, an insect of the Pentatomidae family of Hemiptera. "Chinese Pharmacopoeia" (2015 edition) records that Jiuxiangworm has the effe...
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