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Application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and/or chemotherapy to treat tumors, and pharmaceutical composition

A technology for cordycepin and composition, applied in the field of medicine, can solve the problems of large side effects and low efficiency, and achieve the effects of small side effects, high action efficiency and reduced damage

Active Publication Date: 2015-12-02
SHENZHEN BEIANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the defects of low efficiency and large side effects when the method provided by the prior art is used to improve the immunity of cancer patients receiving radiotherapy and / or chemotherapy, and to provide cordycepin in the preparation of synergistic treatment with radiotherapy and / or chemotherapy. Application in tumor medicine and a pharmaceutical composition for synergistic treatment of tumor with radiotherapy and / or chemotherapy

Method used

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  • Application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and/or chemotherapy to treat tumors, and pharmaceutical composition
  • Application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and/or chemotherapy to treat tumors, and pharmaceutical composition
  • Application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and/or chemotherapy to treat tumors, and pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] This example illustrates the application of cordycepin according to the present invention in the preparation of a drug for synergistic treatment of lung cancer with chemotherapy at the cellular level, specifically:

[0062] The method provided by CN103272216A is used to cultivate lung cancer cells, specifically: human lung adenocarcinoma A-549 cells are activated and passaged according to conventional culture methods, wherein the culture medium is RPMI1640+1% double antibody+10% FBS (in RPMI1640 (Invitrogen , 11875-093) by adding penicillin, streptomycin mixed solution and fetal bovine serum (FBS), so that the final content of the former two is 1% by volume, and the content of FBS is 10% by volume (obtained culture solution).

[0063] The synergistic effect of cordycepin and chemotherapy on human lung adenocarcinoma A-549 cells was detected by thiazolium blue colorimetric method (MTT). The specific method is as follows: select the P8 generation human lung adenocarcinoma...

Embodiment 2

[0078] This example illustrates the application of cordycepin according to the present invention in the preparation of a drug for the synergistic treatment of colon cancer with chemotherapy at the animal level, specifically:

[0079] Modeling: Create a mouse colon cancer model using the method provided by the existing technology ("Replication of a colitis-related colon cancer model", Li Yuhua et al., World Chinese Journal of Digestion, 2007, 15(3): 234-239) , specifically: after 1 week of intraperitoneal injection of 15 mg / kg of dimethylhydrazine (DMH) to the mice to be modeled, give the mice to drink water containing 20 g / L of dextran sodium (DSS) for one week, and then After 20 weeks of normal feeding, 10 model mice were randomly selected and sacrificed. It was found that the cancer formation rate reached 100%, and the conclusion was that the model was successfully established.

[0080] Get 50 (18-20g) above-mentioned colon cancer model mice, after intraperitoneal injection ...

Embodiment 3

[0090] This example illustrates the application of cordycepin according to the present invention in the preparation of drugs for the synergistic treatment of colon cancer with radiotherapy at the animal level, specifically:

[0091] The modeling method is the same as in Example 2.

[0092] 80 (18-20g) colon cancer model mice were randomly divided into groups (10 mice in each group), named as high-dose radiotherapy group, medium-dose radiotherapy group, low-dose radiotherapy group, high-dose non-radiation therapy group, and middle-dose radiotherapy group. Non-radiotherapy group, low-dose non-radiotherapy group, radiotherapy group and control group, the treatment of each group of mice is as follows:

[0093] High-dose radiotherapy group: During the period of radiotherapy for the mice, 50 microliters of 90 mg / kg body weight cordycepin aqueous solution was administered to the experimental mice once a day in the morning, noon and evening, and continued until 2 weeks after the end o...

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Abstract

The invention relates to the field of medicine and discloses application of cordycepin in preparation of pharmaceuticals cooperating with radiotherapy and / or chemotherapy to treat tumors. The cordycepin has a structure shown in the following formula (1). The invention further discloses a pharmaceutical composition cooperating with radiotherapy and / or chemotherapy to treat tumors, wherein the pharmaceutical composition comprises active ingredients including the cordycepin and at least one of daunorubicin, dactinomycin and doxorubicin. The doxorubicin has high acting efficiency and low side effect in the application to the preparation of pharmaceuticals cooperating with radiotherapy and / or chemotherapy to treat tumors.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of cordycepin in the preparation of a medicine for treating tumors in cooperation with radiotherapy and / or chemotherapy and a pharmaceutical composition for treating tumors in cooperation with radiotherapy and / or chemotherapy. Background technique [0002] Currently, the main means of treating malignant tumors include radiotherapy and chemotherapy, and about 90% of malignant tumors clinically require radiotherapy and / or chemotherapy. [0003] The so-called chemotherapy is mainly to treat cancer with drugs that can kill cancer cells. Since the biggest difference between cancer cells and normal cells is that the cell division and cell growth of cancer cells are compared with normal cells, the principle of action of anticancer drugs is usually by interfering with normal cells. Cell division mechanisms to inhibit the growth of cancer cells, such as inhibiting DNA replication o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/7076A61P35/00
Inventor 成果陈维瑜李军卫
Owner SHENZHEN BEIANG BIOTECH CO LTD
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