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Csf1r binding agents

A R-A-S-Q-S-V-X1-Y-X2-G-X3-N-Y-L-X4, X1-A-S-X2-X3-X4-T technology, applied in the field of CSF1R binding agent, can solve the problem of unsatisfactory humanized form

Pending Publication Date: 2020-10-16
超人十二有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This humanized form of 0301 described in WO2011 / 140249A2 is not ideal for the above reasons

Method used

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Examples

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Effect test

example 1

[0374] Example 1: Generation of optimized anti-CSF1R therapeutic antibodies

[0375] introduce

[0376] In this example, a panel of optimized agonistic anti-CSF1R antibodies was successfully generated. These anti-CSF1R antibodies are well expressed, biophysically stable, highly soluble and have the highest identity to the preferred human germline.

[0377] Materials and methods

[0378] CSF1R library generation and selection

[0379] The CSF1R Fab library was assembled by large-scale oligonucleotide synthesis and PCR. The amplified Fab pool was then cloned into a phagemid vector by restriction-ligation, transformed into E. coli TG-1 cells, and the phage pool was rescued essentially as previously described in detail (Finlay et al., 2011, Methods Mol Biol. 681:383-401).

[0380] Phage selection was performed by coating streptavidin magnetic beads with biotinylated CSF1R target protein (human or cynomolgus monkey), washing the beads three times with PBS and resuspending ...

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Abstract

Provided herein are antibody molecules that bind specifically to Colony Stimulating Factor 1 Receptor (CSF1R) and related nucleic acid molecules, vectors and host cells. Also provided herein are medical uses of such antibody molecules.

Description

[0001] Cross References to Related Applications [0002] This application claims UK Patent Application No. 1819045.4 filed on 22 November 2018, UK Patent Application No. 1810226.9 filed on 21 June 2018 and UK Patent Application No. 1803226.8 filed on 28 February 2018 The disclosure of each of these UK patent applications is hereby incorporated by reference in its entirety. [0003] Instructions for text files submitted electronically [0004] The contents of the text file filed electronically with this application are hereby incorporated by reference in their entirety: Copy of Sequence Listing in Computer Readable Form (File Name: ULTL_001_01WO_SeqList_ST25.txt, Date of Record: February 28, 2019, File Size 158,222 byte). technical field [0005] The present invention relates to antibody molecules that specifically bind to CSF1R (also known as colony-stimulating factor 1 receptor, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R) and their medical use. Background te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28
CPCC07K16/2866C07K2317/21C07K2317/565C07K2317/567C07K2317/92
Inventor W·J·J·芬雷
Owner 超人十二有限公司
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