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Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for inhibiting cardiac fibrosis

A kind of technology of hydroxyphenyladenosine and cardiac fibrosis, applied in the field of medicine

Pending Publication Date: 2020-10-27
BEIJING GUSHEN LIFE HEALTH TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] There is no report about the application of IMM-H007 in the preparation of drugs for inhibiting cardiac fibrosis

Method used

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  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for inhibiting cardiac fibrosis
  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for inhibiting cardiac fibrosis
  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for inhibiting cardiac fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 tablet

[0043] Get 5g compound IMM-H007, mix with 15g starch evenly, add povidone as binding agent, granulate and press tablet, make 100 tablets.

Embodiment 2

[0044] The preparation of embodiment 2 drop pill preparation

[0045] Take 5g of compound IMM-H007, mix evenly with 10.5g of polyethylene glycol-6000, heat and melt, transfer the material to drip irrigation, drop the drug solution into liquid paraffin at 6-8°C, remove oil, and prepare drop Pills 100 capsules.

Embodiment 3

[0046] Embodiment 3 injection

[0047] Take 5g of compound IMM-H007, 4.5g of glucose, 0.9g of sodium thiosulfate and 1ml of distilled water, mix the above components evenly, freeze-dry, and divide into 100 tubes to obtain the product.

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PUM

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Abstract

The invention relates to an application of triacetyl-3-hydroxyphenyladenosine in preparation of a medicine for inhibiting cardiac fibrosis. The triacetyl-3-hydroxyphenyladenosine has a chemical name of 2',3',5'-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine, and a structural formula as shown in a formula I.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of triacetyl-3-hydroxyphenyl adenosine. Background technique [0002] Triacetyl-3-hydroxyphenyladenosine, chemical name: 2’,3’,5’-tri-O-acetyl-N 6 -(3-hydroxyphenyl) adenosine (triacetyl-3-hydroxyphenyladenosine, referred to as IMM-H007, WS070117), the compound is disclosed by Chinese patent CN101874036A (Chinese application number 200980101131.6), and its structural formula is shown in formula I, [0003] [0004] It uses inosine nucleoside as a raw material, and is obtained through acetylation of acetic anhydride, chlorination of thionyl chloride, and substitution of 3-hydroxyaniline. The patent also discloses its use in reducing blood lipids. [0005] The following patents disclose new uses of the above compounds, such as: [0006] 201110009204.8 (publication number is CN102125580A) discloses the application of triacetyl-3-hydroxyphenyladenosine THPA in the pre...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P9/00
CPCA61K31/7076A61P9/00
Inventor 朱海波王国成杨海龙杨柳渠凯
Owner BEIJING GUSHEN LIFE HEALTH TECH CO LTD
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