Application of Yubeinine to preparation of medicine for preventing or treating non-alcoholic fatty liver disease

A technology for non-alcoholic and fatty liver disease, which is applied in the application field of ubimethine in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. Or the effect of treating non-alcoholic fatty liver disease, improving body weight, and reducing the level of inflammatory factors

Active Publication Date: 2020-11-03
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yubeinine is one of the main chemical components of Yumin Fritillaria, which belongs to alkaloid compounds. Although alkaloids generally have a wide range of biological activities, there is currently a lack of research on the biological activity of Yubeinine. research report

Method used

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  • Application of Yubeinine to preparation of medicine for preventing or treating non-alcoholic fatty liver disease
  • Application of Yubeinine to preparation of medicine for preventing or treating non-alcoholic fatty liver disease
  • Application of Yubeinine to preparation of medicine for preventing or treating non-alcoholic fatty liver disease

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Embodiment 1

[0046]Experimental animals and feeding conditions: All animal experiments in the present invention were carried out in strict accordance with the experimental animal management regulations issued by the Experimental Animal Management Committee of Zhejiang University of Traditional Chinese Medicine. Male Sprague-Dawley rats (180-200g, 8 weeks old, from Shanghai Slack Experimental Animal Co., Ltd., company license number: SCXK (Shanghai) 2017-0005) were raised in a clean animal laboratory. The temperature of the animal room is 21±2.0°C, the humidity is 50±5%, and the lighting time is 12 hours (8:00-20:00). The animals were fed in single cages, and had free access to water and food during the experiment.

[0047] High-fat-induced NAFLD animal model and euficin intervention: After one week of adaptive feeding, the rats were randomly divided into 5 groups, 10 in each group, respectively control group (control) and model group (HFD), HFD + euficin Low-dose group, HFD+dubicine middl...

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Abstract

The invention discloses an application of Yubeinine to preparation of a medicine for preventing or treating non-alcoholic fatty liver disease, and belongs to the technical field of medicines. The Yubeinine can improve liver cell lipid deposition, inflammatory cell infiltration and liver injury of NAFLD rats, improve weight, blood fat, body oxidative stress degree and inflammatory factor release ofthe NAFLD rats. The level of inflammatory factors released by inflammatory cells is reduced, and the oxidative stress level of hepatocytes is reduced, so that the purpose of preventing or treating the non-alcoholic fatty liver disease is achieved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of yubeijiao in the preparation of drugs for preventing or treating non-alcoholic fatty liver disease. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by lipid deposition and vacuolar degeneration in hepatic parenchymal cells without a history of excessive alcohol consumption. With the aggravation of liver cell lipid deposition and inflammatory response, about 20% of NAFLD patients can develop into non-alcoholic steatohepatitis, and some non-alcoholic steatohepatitis will further develop into hepatic fibrosis and liver cancer. The pathogenesis of NAFLD is still inconclusive, and the accepted theory is the "multiple hit" theory: in the early stage of NAFLD, lipid deposition occurs first in liver cells; with the increase of lipid deposition, the resulting lipotoxicity induces oxidative stress, le...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P1/16
CPCA61K31/4375A61P1/16
Inventor 李松涛宁华毛建华仁大喜相兴伟韩强窦晓兵钱倩宇
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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