Application of Yubeinine to preparation of medicine for preventing or treating non-alcoholic fatty liver disease

A technology for non-alcoholic and fatty liver disease, which is applied in the application field of ubimethine in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. Or the effect of treating non-alcoholic fatty liver disease, improving body weight, and reducing the level of inflammatory factors
CN111870599AActive Publication Date: 2020-11-03ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG CHINESE MEDICAL UNIVERSITY
Publication Date
2020-11-03

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Abstract

The invention discloses an application of Yubeinine to preparation of a medicine for preventing or treating non-alcoholic fatty liver disease, and belongs to the technical field of medicines. The Yubeinine can improve liver cell lipid deposition, inflammatory cell infiltration and liver injury of NAFLD rats, improve weight, blood fat, body oxidative stress degree and inflammatory factor release ofthe NAFLD rats. The level of inflammatory factors released by inflammatory cells is reduced, and the oxidative stress level of hepatocytes is reduced, so that the purpose of preventing or treating the non-alcoholic fatty liver disease is achieved.
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Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to the application of yubeijiao in the preparation of drugs for preventing or treating non-alcoholic fatty liver disease. Background technique

[0002] Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by lipid deposition and vacuolar degeneration in hepatic parenchymal cells without a history of excessive alcohol consumption. With the aggravation of liver cell lipid deposition and inflammatory response, about 20% of NAFLD patients can develop into non-alcoholic steatohepatitis, and some non-alcoholic steatohepatitis will further develop into hepatic fibrosis and liver cancer. The pathogenesis of NAFLD is still inconclusive, and the accepted theory is the "multiple hit" theory: in the early stage of NAFLD, lipid deposition occurs first in liver cells; with the increase of lipid deposition, the resulting lipotoxicity induces oxidative stress, le...

Claims

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