Application of Yubeijialin in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease

A technology for non-alcoholic and fatty liver disease, which is applied in the application field of ubimethine in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. Or the effect of treating non-alcoholic fatty liver disease, reducing the level of inflammatory factors, and reducing the level of oxidative stress in liver cells

Active Publication Date: 2022-05-17
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yubeinine is one of the main chemical components of Yumin Fritillaria, which belongs to alkaloid compounds. Although alkaloids generally have a wide range of biological activities, there is currently a lack of research on the biological activity of Yubeinine. research report

Method used

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  • Application of Yubeijialin in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease
  • Application of Yubeijialin in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease
  • Application of Yubeijialin in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease

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Embodiment 1

[0046] Experimental animals and feeding conditions: All animal experiments in the present invention are carried out in strict accordance with the laboratory animal management regulations issued by the Laboratory Animal Management Committee of Zhejiang University of Traditional Chinese Medicine. Male Sprague-Dawley rats (180-200 g, 8 weeks old, from Shanghai Slack Laboratory Animal Co., Ltd., company license number: SCXK (Shanghai) 2017-0005), raised in a clean grade animal laboratory. The temperature of the animal chamber is 21±2.0 °C, the humidity is 50±5%, and the lighting time is 12h (8:00-20:00). Animals are fed in a single cage, and drink and eat freely during the experiment.

[0047]High-fat induced NAFLD animal model and Yubemethane intervention: Rats were randomly divided into 5 groups of 10 individuals after one week of adaptive feeding, which were control group and model group (HFD), HFD + Yubemethan low-dose group, HFD + Yubeimethane medium dose group, HFD + Yubeimetha...

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Abstract

The invention discloses the application of ruficin in the preparation of drugs for preventing or treating non-alcoholic fatty liver disease, belonging to the technical field of medicine, and can improve hepatocyte lipid deposition, inflammatory cell infiltration and liver damage in NAFLD rats , improve the body weight, blood lipids, body oxidative stress and release of inflammatory factors in NAFLD rats, reduce the level of inflammatory factors released by inflammatory cells, and reduce the level of oxidative stress in liver cells, so as to achieve the purpose of preventing or treating non-alcoholic fatty liver disease.

Description

Technical field [0001] The present invention relates to the field of pharmaceutical technology, in particular to the application of Yubemethan in the preparation of drugs for the prevention or treatment of non-alcoholic fatty liver disease. Background [0002] Non-alconholic fatty liver disease (NAFLD) is a chronic metabolic disease in which lipid deposition and vacuole degeneration occur in hepatic parenchymal cells without a history of excessive alcohol consumption. With the aggravation of lipid deposition and inflammatory response in hepatocytes, about 20% of patients with NAFLD can progress to non-alcoholic steatohepatitis, and some non-alcoholic steatohepatitis further develop into hepatocellular fibrosis and liver cancer. The pathogenesis of NAFLD is currently inconclusive, and the accepted theory is the "multiple strike" theory: lipid deposition occurs first in hepatocytes in the early stage of NAFLD; as lipid deposition increases, the lipotoxic effects produced induce ox...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P1/16
CPCA61K31/4375A61P1/16
Inventor 李松涛宁华毛建华任大喜相兴伟韩强窦晓兵钱倩宇
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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