Application of pyrroloquinoline quinone to medicines resistant to asthma and allergic reaction
A pyrroloquinoline quinone and allergy technology, which can be applied to drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve problems such as high cost, and achieve alleviation of airway inflammation, allergy, and strong anti-oxidation. and anti-inflammatory effects
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[0022] The synthesis of pyrroloquinoline quinone (PPQ) requires 7 genes, which are pyrroloquinoline quinone A to G genes, as shown in Table 1.
[0023] Table 1
[0024] PQQ synthetic gene Features wxya Provides precursors for PQQ biosynthesis wxya Modify the existing transporter to realize the transport of PQQ from the plasma membrane to the cytoplasm wxya Enzymes that catalyze the last step in the synthesis of PQQ wxya Necessary enzyme, function is not yet clear wxya Cofactor for PQQ synthesis reaction wxya It is cleaved from the pqqA precursor after the precursor completes cyclization wxya It is cleaved from the pqqA precursor after the precursor completes cyclization
[0025] The synthetic process of pyrroloquinoline quinone:
[0026] The raw materials are tyrosine and glutamic acid, which constitute the basic skeleton of the ring structure of pyrroloquinoline quinone. The synthesis process is as follows:
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