Method for diagnosing allergic airway inflammation
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A technology for airway inflammation and allergic rhinitis, applied in the field of biomedicine
Active Publication Date: 2021-12-21
CHANGZHOU NO 2 PEOPLES HOSPITAL
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There are currently no biomarkers for the diagnosis of CARAS
Method used
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Embodiment 1
[0048] Example 1 Real Time PCR Detection of Changes in the Expression of Target Genes in Blood Samples of Patients with Allergic Rhinitis-Asthma Syndrome
[0049] 1. Purpose of the experiment
[0050] The SYBR GreenⅠReal Time PCR method was used to detect the changes of lncRNA transcription level of the target gene in the blood samples of patients with allergic rhinitis-asthma syndrome.
[0051] 2. Experimental materials
[0052] 1. Sample Checklist
[0053] In this study, 20 patients with allergic rhinitis-asthma syndrome and 20 normal subjects were recruited. The clinical information is shown in Table 1. Blood samples were collected for analysis and research.
[0054] Table 1 Basic clinical information of the people involved in this study
[0055]
[0056]
[0057] 2. Experimental main reagents
[0058] Table 2 List of Reagents Used
[0059]
[0060] 3. The main instruments of the experiment
[0061] Table 3 List of instruments used
[0062] equipme...
Embodiment 2
[0119] Example 2 Verification of diagnostic efficacy of OVCH1-AS1
[0120] Receiver operating curve (ROC) was drawn by SPSS software, AUC value, sensitivity and specificity were analyzed, and the diagnostic efficacy of the indicators alone was judged.
[0121] As shown in Table 9, Figure 5 As shown, OVCH1-AS1 has a high diagnostic efficiency (AUC value 0.705, sensitivity value 1.000, specificity value 0.500), suggesting that OVCH1-AS1 can be used to diagnose allergic rhinitis-asthma syndrome.
[0122] Table 9 The area under the ROC curve
[0123]
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Abstract
The invention discloses a method for diagnosing allergic airway inflammation. Specifically, the inventor discovers a non-coding RNA capable of being used for diagnosing the allergic airway inflammation, and the non-coding RNA is OVCH1-AS1. As a diagnostic marker, the non-coding RNA has good sensitivity and specificity on the allergic airway inflammation, can be used for diagnosing the allergic airway inflammation, and has an important guiding effect on treatment and medication of the allergic airway inflammation.
Description
technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a method for diagnosing allergic airway inflammation. Background technique [0002] With the development of medicine, many researchers have realized that allergic rhinitis and asthma often exist at the same time. Clinically, some patients mainly suffer from allergic rhinitis while asthma is undiagnosed or in a subclinical state, while more patients may have both diseases at the same time. Therefore, the new medical term of allergic rhinitis-asthma syndrome (Combined Allergic Rhinitis and Asthma Syndrome, CARAS) has been proposed in recent years. The relationship between allergic rhinitis and asthma stems from the continuity of the respiratory tract. The respiratory tract starts from the nasal cavity and ends at the alveoli, and is continuous in anatomical structure and physiological function. As a result, some scholars have long put forward similar new concepts such as "...
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