medical composition, traditional Chinese medicine composition, traditional Chinese medicine extract, preparation of traditional Chinese medicine extract, medicament and application of medical composition, traditional Chinese medicine composition and traditional Chinese medicine extract
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A composition and drug technology, applied in the field of medicine, can solve problems such as side effects, drug resistance, and uncertain curative effect
Active Publication Date: 2020-11-17
SHANGHAI HAIJU BIOLOGICAL TECH CO LTD
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[0004] Most of the current Chinese medicine preparations are made of traditional Chinese herbal formulas through addition and subtraction. There is no recognized effective mechanism, the curative effect is not exact, and the course of treatment is long. Long-term use is prone to side effects or drug resistance.
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[0170] The preparation method of mangosteen fruit peel extract in technology one is as follows:
[0171] 2.5 kg of mangosteen pericarp was crushed and passed through a 10-mesh sieve, then 20 L of 75% (v / v) ethanol-water was added and heated under reflux to extract twice, each time for 2 hours. The extracts were combined, filtered with gauze, centrifuged at 1200 rpm for 10 minutes, the supernatant was concentrated, and freeze-dried to obtain a mangosteen pericarp extract (300 g). The above extract was dissolved in an appropriate amount of water, filtered, and the filtrate was subjected to open column chromatography on a macroporous resin HP-20, ethanol-water gradient elution. It was eluted successively with water, 30% (v / v) ethanol-water, and 90% (v / v) ethanol-water. Collect the eluted part of 90 (v / v) ethanol-water, concentrate under reduced pressure, control the temperature below 55°C, control the vacuum degree above 0.05MPa, and concentrate to about 25 degrees Celsius to ob...
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Abstract
The invention discloses a medical composition, a traditional Chinese medicine composition, a traditional Chinese medicine extract, preparation of the traditional Chinese medicine extract, a medicamentand an application of the medical composition, the traditional Chinese medicine composition and the traditional Chinese medicine extract. The active ingredients of the medical composition comprise 20% or above of an NE inhibitor, 10% or above of an ROS inhibitor, 10% or above of an inhibitor of the NF-[kappa] B inflammatory pathway, and 15% or above of an ACE2 agonist. The medical composition, the traditional Chinese medicine composition, the traditional Chinese medicine extract and the medicament provided by the invention have remarkable effects of diminishing inflammation, relieving a cough, eliminating phlegm and reducing high secretion of respiratory tract mucus.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition, a traditional Chinese medicine composition and its extract, as well as its preparation, medicament and use. Background technique [0002] With the acceleration of urbanization and industrial processes, pollutants such as dust, bacteria, viruses, and inhalable particles in the air are seriously exceeding the standard, and they can easily enter the bronchi, alveoli and other tissues through the nasal cavity and oral cavity of the human body, resulting in hypersecretion of airway mucus. And then cause human respiratory system diseases, such as pharyngitis, rhinitis, sinusitis, emphysema, pneumonia, chronic obstructive pulmonary disease, etc., clinical manifestations are cough, expectoration, runny nose, nasal congestion, dyspnea, etc. [0003] Airway mucus hypersecretion is a complex pathological process involving multiple cellular pathways. At present, the res...
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