Lactobacillus rhamnosus with immunomodulatory effect and application of lactobacillus rhamnosus

A technology of Lactobacillus rhamnosus and immune regulation, applied in the field of Lactobacillus, can solve problems such as differences in immune efficacy, limited number of probiotics, etc., and achieve the effect of good regulation.

Inactive Publication Date: 2020-11-17
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the number of probiotics that can be added to food in compliance with the regulations of the Ministry of Health is still very limited, and the actual immune efficacy of different strains of the same genus is also significantly different, and there is no clear rule to follow

Method used

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  • Lactobacillus rhamnosus with immunomodulatory effect and application of lactobacillus rhamnosus
  • Lactobacillus rhamnosus with immunomodulatory effect and application of lactobacillus rhamnosus
  • Lactobacillus rhamnosus with immunomodulatory effect and application of lactobacillus rhamnosus

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specific Embodiment approach 1

[0030] Specific embodiment 1: This embodiment records a strain of Lactobacillus rhamnosus, L. rhamnosus (L.rhamnosus) 1.0320 strain with immunoregulatory effect, which is preserved in the China Microorganism Culture Collection Management Committee General Microbiology Center, the preservation number is CGMCC No.15557, the preservation address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, and the preservation date is April 08, 2018.

specific Embodiment approach 2

[0031] Specific embodiment two: a strain of Lactobacillus rhamnosus with immunoregulatory effect described in Specific embodiment one, said Lactobacillus rhamnosus is isolated from traditional kumiss.

specific Embodiment approach 3

[0032] Specific embodiment three: a strain of Lactobacillus rhamnosus with immunomodulatory effect described in specific embodiment one, such as Figure 13 and 14 As shown, the colony of the Lactobacillus rhamnosus is milky white, with neat edges, smooth surface, and convex, and the thalline is short rod-shaped.

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Abstract

The invention relates to a lactobacillus rhamnosus strain 1.0320 with an immunomodulatory effect and application of the lactobacillus rhamnosus strain 1.0320. The lactobacillus rhamnosus strain 1.0320is applied to the fermentation process of yoghourt or pickles or used for preparing freeze-dried bacterial powder. According to the lactobacillus rhamnosus, the intestinal wall adhesion rate is high(up to 11.76% or above), the lactobacillus rhamnosus resists low pH (pH is lower than 3), and the lactobacillus rhamnosus resists bile salt (the colony count is 10<7> CFU/mL after the lactobacillus rhamnosus is incubated in 0.3% high-concentration bile salt for 4 hours). The lactobacillus rhamnosus 1.0320 (the ratio of lactobacillus to cells is 1: 1) has very strong regulation capability on a splenic lymphocyte transformation value and NO secreted by peritoneal macrophages, and the immunoregulation capability is obviously higher than that of a reference strain lactobacillus rhamnosus GG (p isless than 0.05). The immunoregulation intensity and concentration of the lactobacillus rhamnosus 1.0320 are positively correlated, when the ratio of lactobacillus rhamnosus 1.0320 to cells is 100: 1,the splenic lymphocyte transformation value is 7.5 times that of a positive control group, and the splenic lymphocyte proliferation index reaches 1 or above.

Description

technical field [0001] The invention belongs to the technical field of lactobacillus, and in particular relates to a strain of lactobacillus rhamnosus with immune regulation function and application thereof. Background technique [0002] Cyclophosphamide (CTX) is one of the most commonly used alkylating agent antineoplastic drugs. Like most chemotherapeutic drugs, it can also inhibit the patient's immune system while destroying tumor cells. Difficulties in the application of chemotherapy. Immunosuppression can lead to an increased incidence of hypersensitivity disease, autoimmune disease, infectious disease, and neoplasia. Currently, commonly used immunoenhancing drugs in clinical practice include chemically synthesized drugs levamisole and isoprinosine, etc., but they are extremely harmful to liver and kidney functions, and some people may cause adverse reactions such as nausea, vomiting, and abdominal pain after taking them. Therefore, it is very important to find safe a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A23L19/20A23C9/12A61K35/747A61P37/02C12R1/225
CPCC12N1/20A23L19/20A23C9/1234A61K35/747A61P37/02A23V2002/00C12R2001/225C12N1/205A23V2200/30A23V2400/175
Inventor 侯俊财姜瞻梅王惋高达徐聪
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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