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Combination of Anti-hgfr antibody and hegfr for the treatment of a tumor and/or metastasis

An antibody fragment, receptor technology, applied in the field of combination of anti-GHFR antibodies and HEGFR for the treatment of tumors and/or metastases, can solve problems such as enhancing malignant phenotypes

Pending Publication Date: 2020-12-04
垂直生物股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the absence of specific genetic damage, MET is not strictly necessary for tumor growth, but the presence of the ligand maintains receptor activation, thereby enhancing the malignant phenotype

Method used

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  • Combination of Anti-hgfr antibody and hegfr for the treatment of a tumor and/or metastasis
  • Combination of Anti-hgfr antibody and hegfr for the treatment of a tumor and/or metastasis
  • Combination of Anti-hgfr antibody and hegfr for the treatment of a tumor and/or metastasis

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Embodiment Construction

[0037] In the following description, numerous specific details are given to provide a thorough understanding of the embodiments. The embodiments may be practiced without one or more of the specific details, or may be practiced using other methods, components, materials, and the like. In other instances, well-known structures, materials, or operations are not shown or described in detail to avoid obscuring aspects of the embodiments.

[0038]Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures or characteristics may be combined in any suitable manner in one or more embodiments.

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Abstract

Disclosed is a combination of an anti-HGFR antibody fragment with an extracellular portion of a person HGFR for treatment of a patient suffering a tumor and / or metastasis, wherein: (i) the anti-HGFR antibody fragment has only one paratope able to bind to an epitope of the extracellular portion of human HGFR and has antagonist activity towards HGFR, (ii) the extracellular portion of human HGFR is capable of binding to HGF in a stable manner and contains at least one amino acid mutation at the epitope recognized by the anti-HGFR antibody fragment to prevent binding of the anti-HGFR antibody fragment thereto, and (iii) the anti-HGFR antibody fragment and the extracellular portion of human HGFR are suitable for administration to the patient are suitable for administration to the patient (a) ina protein form or (b) in a nucleic acid form.

Description

technical field [0001] The present disclosure relates to novel combinations of therapeutic agents for the treatment of tumors and / or metastases, preferably metastases. Background technique [0002] Metastatic spread is based on the ability of cancer cells to disrupt cell-cell interactions, migrate through the extracellular matrix, survive and proliferate in tissues other than their site of origin. The physiological counterpart to this complex program (termed "invasive growth") underlies embryogenesis and is responsible for wound healing and organ regeneration in adulthood. Invasive growth is tightly regulated by specific extracellular signals, one of which is hepatocyte growth factor (HGF), a ligand for a receptor encoded by the MET oncogene. When aberrantly activated, HGF / MET signaling drives tumor initiation, progression and metastasis in a wide range of human malignancies. In a few instances, MET appears to "drive" an oncogene, and tumor cells depend on constitutive MET...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/22A61K38/17A61K39/395C07K16/28
CPCC07K16/2863C07K2317/55C07K2317/73C07K2317/76C07K2319/00A61K38/179A61K39/3955A61K2039/505A61K2300/00C07K14/71C12N15/62A61P35/00A61K38/00A61P31/00A61K39/39558C07K2317/52C07K2317/522C07K2317/565C07K2317/622
Inventor C·巴西利克E·维格纳P·M·科蒙利奥
Owner 垂直生物股份有限公司
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