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Application of polygala fallax hemsl extract to preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and P. japonica is applied in directions such as drug combinations, antipyretics, anti-inflammatory agents, etc., and can solve problems such as no reports on the application of P. japonica.

Pending Publication Date: 2020-12-08
武汉自在生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the application of the lotus chrysanthemum in the preparation of medicines for the treatment of ulcerative colitis

Method used

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  • Application of polygala fallax hemsl extract to preparation of medicine for treating ulcerative colitis
  • Application of polygala fallax hemsl extract to preparation of medicine for treating ulcerative colitis
  • Application of polygala fallax hemsl extract to preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The preparation of embodiment 1 chrysanthemum lotus extract

[0012] Take 1000g of the medicinal material of chrysanthemum chrysalis, add 8 times of water to decoct twice for 1.5 hours each time, filter, combine the decoction liquid and concentrate it into a thick paste, dry under reduced pressure, and pulverize to obtain the water extract of chrysanthemum chrysalis.

[0013] Get 1000g of the lotus chrysanthemum medicinal material, add 20%, 40%, 60%, 80% (volume) ethanol reflux extraction of 8 times of weight respectively, the number of times of extraction is 2 times, the time of each reflux extraction is 1.5 hours, filter, The reflux liquids were combined and concentrated into a thick paste, dried under reduced pressure, and crushed to obtain ethanol extracts of different concentrations of the lotus.

Embodiment 2

[0014] Example 2 efficacy verification

[0015] 1. Experimental materials and reagents

[0016] 1.1 Experimental materials

[0017] 70 SPF grade C57BL / 6 male mice aged 6-8 weeks.

[0018] 1.2 Experimental reagents

[0019] Dextran sodium sulfate (DSS, M0910A, Dalian Meilun Biotechnology Co., Ltd.), occult blood kit (C027-1-1, Nanjing Jiancheng Bioengineering Institute).

[0020] 1.3 Experimental drugs

[0021] The lotus water prepared in Example 1 and the ethanol extracts of different concentrations.

[0022] 2. Experimental method

[0023] 2.1 Establishment and treatment of experimental animal models of ulcerative colitis

[0024] A total of 70 SPF grade C57BL / 6 male mice aged 6-8 weeks were bought back and fed adaptively for 3 days. They were randomly divided into 7 groups, 10 mice in each group, which were normal control group and DSS model group (3%) , Huanghua lotus water and different concentrations of ethanol extract group (15g / kg / d, according to medicinal materi...

Embodiment 3

[0045] Get 100g of the lotus chrysanthemum medicinal material, add 8 times the weight of 60% (volume) ethanol to reflux and extract twice, filter, combine the reflux liquid and concentrate into a thick paste, then add sherwood oil to the thick paste to extract three times for degreasing, discard Petroleum ether phase, and the remaining solution was extracted three times with water-saturated n-butanol, the organic solvent was recovered, concentrated, and dried to obtain the degreased n-butanol part of the ethanol extract of the lotus chrysanthemum.

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Abstract

The invention discloses an application of a polygala fallax hemsl extract to preparation of a medicine for treating ulcerative colitis. Animal test results show that the polygala fallax hemsl extractcomprises a water extract and an alcohol extract, can improve the weight, the food intake, the spleen coefficient and the thymus coefficient of an ulcerative colitis mouse animal model, reduces the disease activity index (DAI) and increases the colon length, and shows that the polygala fallax hemsl extract has a treatment effect on ulcerative colitis.

Description

technical field [0001] The invention belongs to a new pharmaceutical application involving the extract of the lotus chrysanthemum, especially the application in preparing medicine for treating ulcerative colitis, and belongs to the field of pharmaceuticals. Background technique [0002] Yellow flower pouring lotus (Polygala fallax Hemsl.) is the root of the deciduous shrubs of Polygala family Polygala, also known as false yellow polygala, yellow ginseng, inverted yellow, etc. Jiangxi, Fujian, Guizhou, Guangxi and northern Guangxi and other regions. The taste is sweet and slightly bitter, and the nature is flat and slightly warm. It has the effects of nourishing qi and blood, invigorating the spleen and removing dampness, promoting blood circulation and dispelling blood stasis. Leg pain, bruises, acute and chronic hepatitis, etc. Huanghua daoshuilian is a commonly used medicine of ethnic minorities such as Zhuang, Yao, and Miao. It is also used as "Dangshen" and "Astragalus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P1/00A61P29/00
CPCA61K36/69A61P1/00A61P29/00
Inventor 陈滨
Owner 武汉自在生物科技有限公司
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