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A lysozyme oral care product for whitening teeth

A technology of oral care and lysozyme, which is applied in the field of oral care, can solve the problems of unfriendly oral products, achieve the effects of antibacterial and whitening effects, reduce production costs, and reduce dental stain index

Active Publication Date: 2022-03-01
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent application 201910022267.3 discloses a gel for whitening teeth. The gel adds a large amount of peroxide stabilizer to stabilize hydrogen peroxide. Although the stabilization effect is better and the gel system is more stable, the excessive chemical stabilizer Join, not friendly to oral supplies

Method used

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  • A lysozyme oral care product for whitening teeth
  • A lysozyme oral care product for whitening teeth
  • A lysozyme oral care product for whitening teeth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The formula of embodiment 1 paste A series and paste B series

[0036] This example provides a series of lysozyme oral care product formulations for whitening teeth, which consist of paste A and paste B, and paste A and paste B are mixed for use.

[0037] The ingredients of a series of paste A and paste B are shown in Table 1, and each paste A and each paste B are randomly matched to obtain a series of oral care products.

[0038] Table 1:

[0039]

[0040]

Embodiment 2

[0041] Embodiment 2 antibacterial activity experiment

[0042] 1. Antibacterial test method

[0043] According to 7.3 in QB 2738-2012 "Evaluation method of antibacterial and antibacterial effect of daily chemical products" as detection basis, with the inhibition rate to Streptococcus mutans, Porphyromonas gingivalis, Escherichia coli etc. as investigation index, to embodiment 1 The antibacterial effect of oral care products in each group was evaluated. The specific operation method is as follows:

[0044] (1) Dilute Streptococcus mutans, Porphyromonas gingivalis, Escherichia coli and other bacterial species with PBS (0.03mol / L phosphate buffer) to a concentration of 1×10 4 ~9×10 4 cfu / mL;

[0045] (2) each group of oral care product test samples in Example 1 is diluted to a specified concentration with sterile standard hard water;

[0046] (3) Draw 5.0 mL of the test sample stock solution into a sterilized test tube, and keep the temperature at 20°C for 5 minutes;

[0047]...

Embodiment 3

[0061] Embodiment 3 whitening effect (spot index) measurement

[0062] 1. Test method

[0063] (1) Subject population and grouping

[0064] 80 subjects whose physical examination indicators were all normal.

[0065] They were randomly divided into test group 1, test group 2, test group 3 and test group 4, with 20 people in each group, half male and half male; the sample used in test group 1 was paste A0B0 mixed package, and the sample used in test group 2 was Paste A3 is mixed with the same kind, the sample used in test group 3 is the same kind of paste mixed with paste B3, the sample used in test group 4 is mixed with paste A1B1, and the sample used in test group 5 is mixed with paste A3B3.

[0066] (2) Brushing method

[0067] The subjects were uniformly distributed toothpaste and toothbrush, and brushed their teeth once a day in the morning and evening according to the BASS brushing method, a total of 2 times, 1 minute each time.

[0068] (3) Experimental steps

[0069...

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Abstract

The invention discloses a lysozyme oral care product for whitening teeth. The oral care product uses lysozyme, dextrose and glucose oxidase as functional components, and separates the dextrose and glucose oxidase by packaging. The mixture of the two produces peroxide with whitening effect, the stain index is significantly reduced, the freckle and whitening effect is enhanced, and the problem of hydrogen peroxide being unstable and decomposed in the toothpaste system can be avoided; at the same time, peroxide can significantly enhance the effect of lysozyme on Bactericidal and antibacterial effects of oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, and Escherichia coli. The product system of the invention is coordinated, the activity and stability of the lysozyme is good, and the components are synergistically synergistic to jointly achieve whitening and antibacterial effects, and the market prospect is good.

Description

technical field [0001] The invention belongs to the technical field of oral care. More specifically, it relates to a lysozyme oral care product for whitening teeth. Background technique [0002] Lysozyme (Lysozyme) is a non-specific substance in saliva, a kind of muramidase that can hydrolyze mucopolysaccharides in pathogenic bacteria, mainly by destroying N-acetylmuramic acid and N-acetylglucosamine in the cell wall β-1,4 glycosidic linkages between sugars, causing cell wall rupture. Lysozyme can inhibit the growth of microorganisms and selectively dissolve the cell wall of the target microorganism to inactivate it. Mammals have no cell walls, so lysozyme has no damage to oral tissues. Moreover, compared with antibiotics or other antibacterial substances, long-term use of lysozyme will not cause drug resistance. In addition, relevant clinical trials have shown that lysozyme can effectively reduce the plaque index, dissolve dental plaque, and inhibit the formation of dent...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/66A61K8/60A61K8/22A61Q11/00A61P1/02A61P31/02A61P31/04
CPCA61K8/66A61K8/60A61K8/22A61Q11/00A61P1/02A61P31/02A61P31/04A61K2800/592A61K2800/882Y02A50/30
Inventor 褚夫江徐天生耿帅峰欧阳学琭李婷
Owner HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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