Application of 18β-glycyrrhetinic acid in the preparation of products that enhance the body's anti-fatigue ability

A glycyrrhetic acid, anti-fatigue technology, applied in the application field of the product, can solve the problems of the anti-fatigue effect that needs further verification, the suspicion of stimulants, and the high price.

Active Publication Date: 2021-08-31
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-fatigue mechanism of some of the substances involves the neural regulation mechanism and is suspected of being a stimulant; the anti-fatigue effect of some of the substances still needs to be further verified; some of the substances are expensive and not suitable for consumption by the general public

Method used

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  • Application of 18β-glycyrrhetinic acid in the preparation of products that enhance the body's anti-fatigue ability
  • Application of 18β-glycyrrhetinic acid in the preparation of products that enhance the body's anti-fatigue ability
  • Application of 18β-glycyrrhetinic acid in the preparation of products that enhance the body's anti-fatigue ability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 18β-glycyrrhetinic acid alleviates exercise fatigue in mice in endurance exercise + high-intensity accelerated exercise fatigue model.

[0035] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and a formula group (12 mice). By gastric administration, the rest group and the model group were administered 0.1% sodium carboxymethylcellulose every day, and the formula group was administered 25 mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent was 0.1% sodium carboxymethylcellulose. Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the exercise exhaustion time of the mice was measured and the exercise distance was calculated.

[0036] Sports model: experimental animal treadmill. Slope 0°, initial speed 10m / min, increase 2m / min every 15min until 14m / min, accelerate to 20m / min after 15min, increase to 22m / mi...

Embodiment 2

[0040] 18β-glycyrrhetinic acid alleviates exercise fatigue in mice in a high-intensity accelerated exercise fatigue model.

[0041] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and an administration group (12 mice). Adopt intragastric method, the rest group and the model group are intragastrically administered 0.1% sodium carboxymethylcellulose every day, and the administration group is intragastrically administered 25mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent is 0.1% sodium carboxymethylcellulose . Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the exercise exhaustion time of the mice was measured and the exercise distance was calculated.

[0042] Sports model: experimental animal treadmill. The slope is 0°, the initial speed is 5m / min, increase by 5m / min every 5min, and after increasing to ...

Embodiment 3

[0047] 18β-glycyrrhetinic acid alleviates muscle damage in mice in a high-intensity accelerated exercise fatigue model.

[0048] Test method: 36 male C57 BL / 6J mice, 6-8 weeks old, were randomly divided into a resting group (12 mice), a model group (12 mice), and an administration group (12 mice). Adopt intragastric method, the rest group and the model group are intragastrically administered 0.1% sodium carboxymethylcellulose every day, and the administration group is intragastrically administered 25mg / kg bw of 18β-glycyrrhetinic acid every day, and the solvent is 0.1% sodium carboxymethylcellulose . Gavage once a day at 8:30 in the morning. Supplementation continued for 3 days, and 2.5 hours after the last supplementation, the mice in the model group and the administration group ran for 20 minutes uniformly, and blood was collected to determine the creatine kinase content in the serum of the mice.

[0049] Sports model: experimental animal treadmill. The slope is 0°, the i...

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Abstract

The invention belongs to the field of health food, and specifically relates to the application of 18β-glycyrrhetinic acid in the preparation of products for enhancing body anti-fatigue ability. 18β-glycyrrhetinic acid can significantly enhance exercise endurance and delay the occurrence of exercise-induced fatigue. The anti-fatigue food composition of the present invention has an effect after being taken for a short period of time, and when taken 2.5 hours before the start of exhaustive exercise, the exercise endurance of mice can be enhanced, the exercise time can be prolonged, and the exercise distance can be increased. The invention provides new ingredients for developing anti-fatigue health food, and has great application value.

Description

technical field [0001] The invention belongs to the field of health food, and specifically relates to the application of 18β-glycyrrhetinic acid in the preparation of products for enhancing body anti-fatigue ability. Background technique [0002] Fatigue is mediated by a series of complex physiological and biochemical processes and is a common phenomenon in the body. Fatigue is defined as the weakening of the muscle's ability to generate force, making it unable to maintain a predetermined exercise intensity, that is, exercise-induced fatigue. The occurrence of exercise fatigue is often accompanied by changes in energy substances, metabolites, hormone levels, cell metabolism regulating enzymes, and antioxidant system enzymes. The essential reason is that the imbalance of the internal environment homeostasis causes the body to feel uncomfortable. Persistent fatigue or severe fatigue will not only affect people's normal life, but also lead to endocrine disorders, decreased imm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P39/00A23L33/00
CPCA23V2002/00A61K31/56A23L33/00A61P39/00A23V2200/30
Inventor 扈洪波马璇尹淑涛赵冲陈慧曹丽行赵爽
Owner CHINA AGRI UNIV
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