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Use of a reagent for knocking out or inhibiting expression of a Slc16a4 gene in the preparation of a medicine for preventing and / or treating HFpEF
PendingCN122163805AOrganic active ingredientsPharmaceutical non-active ingredientsCardiac fibrosisTargeted interventions
This invention belongs to the field of biomedical technology, specifically involving knockout. Slc16a4 Gene or repression Slc16a4 The application of gene expression reagents in the preparation of drugs for the prevention and / or treatment of HFpEF. This invention involves administering AAV9 virus-packaged Slc16a4 shRNA to mice. Results showed that injection of Slc16a4 shRNA significantly improved diastolic dysfunction, reduced blood pressure, improved exercise tolerance, and alleviated myocardial hypertrophy and cardiac fibrosis in HFpEF mice, thus achieving treatment for HFpEF. This invention provides a highly efficient targeted... Slc16a4 Gene intervention tools provide key technical support for HFpEF-related gene function research and the development of targeted intervention products, and have significant scientific value and application prospects.
Owner:SHANGHAI UNIV