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34 results about "Improved exercise tolerance" patented technology

Genetic risk assessment in heart failure: impact of genetic variation of beta 1 adrenergic receptor gly389arg polymorphism

The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the quality of life in a heart failure patient; (f) inhibiting left ventricular remodeling; (g) reducing hospitalizations related to heart failure; (h) improving exercise tolerance; (j) increasing left ventricular ejection fraction; (k) decreasing levels of B-type natriuretic protein; (l) treating renovascular diseases; (m) treating end-stage renal diseases; (n) reducing cardiomegaly; (o) treating diseases resulting from oxidative stress; (p) treating endothelial dysfunctions; (q) treating diseases caused by endothelial dysfunctions; or (r) treating cardiovascular diseases; in a patient in need thereof, wherein the patient has a Arg389Arg polymorphism and/or a Gly389Gly polymorphism in the beta 1 adrenergic receptor gene, comprising administering to the patient (i) at least one antioxidant compound or a pharmaceutically acceptable salt thereof; (ii) at least one nitric oxide enhancing compound; and (iii) optionally the best current therapy for the treatment of cardiovascular diseases. In one embodiment the antioxidant is a hydralazine compound or a pharmaceutically acceptable salt thereof and the nitric oxide enhancing compound is isosorbide dinitrate and/or isosorbide mononitrate.
Owner:NITROMED +1

Beverage with function of quick physical energy recovery and method for preparing beverage with function of quick physical energy recovery

The invention discloses a beverage with a function of quick physical energy recovery and a method for preparing the beverage with the function of quick physical energy recovery.The beverage is mainly prepared from taurine, inositol, L-tyrosine, AAKG, potassium salt, magnesium salt, citrulline malate, guarana extract, glucuronolactone, maltodextrin, D-ribose, citric acid, potassium sorbate, flavoring agents and the balance purified water.The method includes: dissolving sweeteners into an appropriate amount of purified water and filtering; adding the taurine, the inositol, the L-tyrosine, the AAKG, the potassium salt, the magnesium salt, the citrulline malate, the guarana extract, the glucuronolactone and the like into purified water, dissolving completely, and filtering; well mixing the two solutions, adding the citric acid, the potassium sorbate and the flavoring agents, well mixing, and performing high-temperature sterilization and filling to obtain finished products.The beverage with the function of quick physical energy recovery is capable of not only regulating body fluid equilibrium and improving exercise tolerance but also enhancing anti-fatigue ability and promoting fatigue recovery after exercises.
Owner:JIANGSU ALAND NOURISHMENT

Novel probiotic dendrobium enzyme and production technology thereof

The invention relates to a novel probiotic dendrobium enzyme and production technology thereof and belongs to the technical field of biological medicine. The technology comprises the following nine major steps, namely collecting dendrobium leaves and removing impurities, grinding the dendrobium leaves, carrying out first fermentation, selecting jerusalem artichoke powder, making matrix for second fermentation, acclimatizing and preparing strains for second fermentation, grafting probiotic mother strains of fermentation and performing a second fermentation process, performing a blend process and adding probiotics, carrying out filling and performing packaging. Pharmacological functions of the waste dendrobium leaves, repair functions of the compound probiotics to the micro-ecological environment of the digestive tract and promotion functions of the probiotics to the probiotic floras in the digestive tract are fully utilized in the production technology, so that physiological functions of human body are systematically adjusted by synergetic effects of the three aspects. The probiotic dendrobium enzyme of the invention is capable of promoting micro-ecological environment balance of the digestive tract, obviously improving digestive functions, adjusting organism metabolism and adjusting immunologic function; moreover, the probiotic dendrobium enzyme also has the health-care functions of improving exercise tolerance, accelerating tiredness allaying and protecting the liver.
Owner:昆明宝成生物科技有限公司

Traditional Chinese medicine for treating coronary heart disease stable angina pectoris complicated with diabetes and hypertension

The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine for treating coronary heart disease stable angina pectoris complicated with diabetes and hypertension. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 8-16 parts of radix bupleuri, 6-14 parts of pericarpium citri reticulatae, 6-14 parts of pericarpium citri reticulatae viride, 6-14 parts of citrus chirocarpus, 6-14 parts of fructus citri, 6-14 parts of allium macrostemon, 4-8 parts of gastrodia elata, 5-13 parts of uncaria rhynchophylla, 5-13 parts of tribulus terrestris, 16-24 parts of gypsum, 5-13 parts of rhizoma anemarrhenae, 8-16 parts of dried rehmannia root, 5-13 parts of radix ophiopogonis, 11-19 parts of polished round-grained rice, 5-13 parts of radix puerariae, 4-8 parts of agastache rugosus, 6-14 parts of ginseng, 11-19 parts of codonopsis pilosula, 11-19 parts of radix pseudostellariae, 8-16 parts of rhizoma atractylodis macrocephalae, 5-13 parts of rhizoma atractylodis, 5-13 parts of pinellia ternate, 5-13 parts of rhizoma arisaematis, 16-24 parts of succus bambusae, 6-14 parts of trichosanthes kirilowii maxim, 5-13 parts of thunberg fritillary bulb, 5-13 parts of ligusticum wallichii, 5-13 parts of rhizoma corydalis, 5-13 parts of radix salviae miltiorrhizae, 5-13 parts of safflower carthamus, 1-5 parts of leech and 4-8 parts of liquorice. The traditional Chinese medicine has the functions of improving exercise tolerance of patients with coronary heart disease, reducing paroxysm frequency of angina, reducing blood sugar and blood pressure, improving living quality of the patients and relieving traditional Chinese medicine syndromes of the patients.
Owner:JINAN BANGWEN MEDICAL TECH

Application of HDAC4 inhibitor in preparing medicine for treating heart failure

The invention relates to application of HDAC4 inhibitor in preparing medicine for treating heart failure. According to the application, a heart failure animal model after a mouse is died of myocardialinfarction is established, aerobic exercise interference is carried out, cardiac function, energy metabolism and related signal molecules are assessed by using PET / CT, echocardiography and a molecular biological technique, it is found that the aerobic exercise can improve the cardiac function after infarction, increase exercise tolerance, improve mitochondrion structure function and glycolipid metabolism, and reduce the inhibiting effect of myocardium HDAC4 intra-nuclear genes, it is suggested that the DHAC4 is a molecular action target spot for the aerobic exercise to improve the cardiac function after infarction, medicine promoting the phosphorylation of the DHAC4 or reducing the expression of the DHAC4 can be developed, effect same as rehabilitation exercise can be achieved, complianceis improved, thereby improving symptoms, improving exercise tolerance, reducing case fatality rate, and the application has important clinical significance. The application further suggests that thephosphorylation level of the DHAC4 can serve as a marker for cardiac failure prognosis after myocardial infarction.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Traditional Chinese medicine for treating coronary heart disease stable angina pectoris complicated with diabetes

The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine for treating coronary heart disease stable angina pectoris complicated with diabetes. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 16-24 parts of gypsum, 5-13 parts of rhizoma anemarrhenae, 8-16 parts of dried rehmannia root, 5-13 parts of radix ophiopogonis, 11-19 parts of polished round-grained rice, 5-13 parts of radix puerariae, 4-8 parts of agastache rugosus, 6-14 parts of ginseng, 11-19 parts of codonopsis pilosula, 11-19 parts of radix pseudostellariae, 8-16 parts of bighead atractylodes rhizome, 5-13 parts of rhizoma atractylodis, 5-13 parts of pinellia ternate, 5-13 parts of rhizoma arisaematis, 16-24 parts of succus bambusae, 6-14 parts of trichosanthes kirilowii maxim, 5-13 parts of thunberg fritillary bulb, 5-13 parts of ligusticum wallichii, 5-13 parts of rhizoma corydalis, 5-13 parts of radix salviae miltiorrhizae, 5-13 parts of safflower carthamus, 1-5 parts of leech and 4-8 parts of liquorice. The traditional Chinese medicine has the functions of improving exercise tolerance of patients with coronary heart disease, reducing paroxysm frequency of angina, reducing blood sugar, improving living quality of the patients and relieving traditional Chinese medicine syndromes of the patients with coronary heart disease stable angina pectoris complicated with diabetes.
Owner:JINAN BANGWEN MEDICAL TECH

Application of hdac4 inhibitor in preparation of medicine for treating heart failure

The invention relates to application of HDAC4 inhibitor in preparing medicine for treating heart failure. According to the application, a heart failure animal model after a mouse is died of myocardialinfarction is established, aerobic exercise interference is carried out, cardiac function, energy metabolism and related signal molecules are assessed by using PET / CT, echocardiography and a molecular biological technique, it is found that the aerobic exercise can improve the cardiac function after infarction, increase exercise tolerance, improve mitochondrion structure function and glycolipid metabolism, and reduce the inhibiting effect of myocardium HDAC4 intra-nuclear genes, it is suggested that the DHAC4 is a molecular action target spot for the aerobic exercise to improve the cardiac function after infarction, medicine promoting the phosphorylation of the DHAC4 or reducing the expression of the DHAC4 can be developed, effect same as rehabilitation exercise can be achieved, complianceis improved, thereby improving symptoms, improving exercise tolerance, reducing case fatality rate, and the application has important clinical significance. The application further suggests that thephosphorylation level of the DHAC4 can serve as a marker for cardiac failure prognosis after myocardial infarction.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
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