Method for improving fluorination reaction effect in synthesis process of 2-chloro-5-trifluoromethylpyridine and matched system

Abstract

The invention relates to the technical field of chemical synthesis, in particular to a method for improving the fluorination reaction effect in the synthesis process of 2-chloro-5-trifluoromethylpyridine and a matched system. The method comprises the following steps that 2-chloro-5-trifluoromethylpyridine is prepared, subjected to superfine grinding and then enters an efficient reaction system; aproper amount of iodine pentafluoride, mercury fluoride and a catalyst are added into the efficient reaction system; the temperature and the time are controlled, and fluorination reaction is conductedon the material in a high-pressure sealed efficient reaction system to obtain a crude product solution containing 2-chloro-5-trifluoromethylpyridine; and the crude product solution is purified to obtain the 2-chloro-5-trifluoromethylpyridine. According to the method, the fluorination reaction is carried out in a high-pressure sealed environment, so that the efficiency and the effect of the fluorination reaction are effectively improved; through the effect of the system, the fed materials can be quickly subjected to superfine grinding treatment before reaction, so that the reaction sufficiencyin the subsequent reaction process is improved.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for improving the effect of fluorination reaction in the synthesis process of 2-chloro-5-trifluoromethylpyridine and a matching system. Background technique [0002] At present, when carrying out the synthesis of 2-chloro-5-trifluoromethylpyridine, it usually uses 3-methylpyridine as a raw material to be chlorinated to obtain 2-chloro-5-trichloromethylpyridine, and then further fluorinated to obtain 2-chloro-5-trifluoromethylpyridine. To obtain the product; 3-methylpyridine can also be used as raw material to obtain the product by fluorine chlorination reaction in the presence of a catalyst. [0003] However, the existing preparation method usually has a slow reaction speed and poor reaction effect during the fluorination reaction, so the quality of the final product obtained is low and cannot meet the needs of high-efficiency production. [0004] To this end...

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Problems solved by technology

[0003] However, the existing preparation method usually has a slow reaction speed and poor reaction effect during the fluorination reaction, so the final product quality will be low and cannot meet the needs of efficient production

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