Compound, traditional Chinese medicine probiotic fermentation product and application of compound and traditional Chinese medicine probiotic fermentation product in preparation of medicine or health care product with anti-cancer effect

A technology for fermentation products and compounds, applied in the field of biomedicine, can solve the problem of low early diagnosis rate of gastric cancer, and achieve the effect of inhibiting cell proliferation and promoting cell apoptosis

Pending Publication Date: 2021-01-26
刘志刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the low early diagnosis rate of gastric cancer (about 10%), most gastric cancers are already in the middle and advanced stages when they are diagnosed, and the 5-year survival rate is about 7% to 34%.

Method used

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  • Compound, traditional Chinese medicine probiotic fermentation product and application of compound and traditional Chinese medicine probiotic fermentation product in preparation of medicine or health care product with anti-cancer effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application of compound and traditional Chinese medicine probiotic fermentation product in preparation of medicine or health care product with anti-cancer effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application of compound and traditional Chinese medicine probiotic fermentation product in preparation of medicine or health care product with anti-cancer effect

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Effect test

Embodiment 1

[0068] The preparation of embodiment 1 formula (I) compound

[0069] (1) Mix 30 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 50 g of water, and ferment for 24 hours at a temperature of 25°C and a pH of 5.5 to obtain a fermentation broth;

[0070] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0071] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0072] The traditional Chinese medicine raw material described in the step (1) consists of turmeric extract, Ligustrum lucidum extract, Astragalus extract, honeysuckle extract, Sanqi extract, Salvia miltiorrhiza extract and Codonopsis pilosula extract in a weight ratio of 1:1:1: 1:1:1:1 composition; the probiotic dry powder is composed of Lactob...

Embodiment 2

[0076] The preparation of embodiment 2 formula (I) compound

[0077] (1) Mix 300g of traditional Chinese medicine raw materials and 100g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 500g of water, and conduct ultrasonic extraction for 60min; then ferment for 30h at a temperature of 25°C and a pH of 5.5 to obtain fermentation broth;

[0078] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0079] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0080] The traditional Chinese medicine raw material described in the step (1) is composed of turmeric, privet lucidum, astragalus, honeysuckle, Panax notoginseng, salvia miltiorrhiza and Codonopsis pilosula in a weight ratio of 1:1:1:1:1:1:1; the probiotics The dry powder is composed of Lactobacillus acid...

Embodiment 3

[0082] The preparation of embodiment 3 traditional Chinese medicine probiotic fermentation product

[0083] (1) Mix 30 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 50 g of water, and ferment for 24 hours at a temperature of 25°C and a pH of 5.5 to obtain a fermentation broth;

[0084] (2) centrifuging the fermented liquid at 8000r / min for 30 min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a traditional Chinese medicine probiotic fermentation product;

[0085] The Chinese medicine raw material described in the step (1) is by turmeric extract, Ligustrum lucidum extract, Radix Astragali extract, honeysuckle extract, Panax notoginseng extract, salvia miltiorrhiza extract and Codonopsis pilosula extract (described extracts are all conventional The pharmaceutical raw materials can be obtained by purchasing) in a weight ratio of ...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a compound, a traditional Chinese medicine probiotic fermentation product and application of the compound and the traditional Chinese medicine probiotic fermentation product in preparation of anti-cancer drugs or health care products. The compound has a structure shown as a formula (I). The traditional Chinesemedicine probiotic fermentation product comprises a compound as shown in a formula (I) which is described in the specification. The preparation method comprises the following steps: (1) taking traditional Chinese medicine raw materials, and fermenting the traditional Chinese medicine raw materials with probiotics to obtain fermentation broth; and (2) drying the fermentation broth to obtain the traditional Chinese medicine probiotic fermentation product, wherein the traditional Chinese medicine raw materials in the step (1) comprise turmeric, glossy privet fruit, astragalus membranaceus, honeysuckle, pseudo-ginseng, salviae miltiorrhizae and codonopsis pilosula. The compound shown in the formula (I) and the traditional Chinese medicine probiotic fermentation product have an excellent anti-cancer effect, especially an anti-gastric cancer effect, and can be used for preparing medicines and health-care products.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound, a traditional Chinese medicine probiotic fermentation product and its application in the preparation of medicines or health care products with anticancer effects. Background technique [0002] Gastric cancer refers to malignant tumors originating from gastric endothelial cells, mainly gastric adenocarcinoma. Gastric cancer accounts for more than 95% of gastric malignancies. In 2008, nearly 1 million cases of gastric cancer were newly diagnosed in the world, and the number of deaths was 740,000, ranking fourth among all diagnosed cases of malignant tumors and second in the fatality rate of malignant tumors. Although the global incidence of gastric cancer has declined, two-thirds of gastric cancer cases are still distributed in developing countries. From the perspective of geographical distribution, the incidence is relatively high in China, Japan and other Southe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/10C07C231/24C12P13/02A61K31/16A61P35/00A23L33/10A23L33/105A61K36/9066A61K36/638A61K36/481A61K36/355A61K36/258A61K36/537A61K36/344C12R1/23C12R1/01
CPCA23V2002/00A61K31/16A61K36/258A61K36/344A61K36/355A61K36/481A61K36/537A61K36/638A61K36/9066A23L33/10A23L33/105A61P35/00C07C237/10C12P13/02A61K2300/00A23V2200/308A23V2250/21A23V2250/30
Inventor 刘志刚刘杰刘晓宇
Owner 刘志刚
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