Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Terahertz spectrum-based drug identification method

An identification method and terahertz technology, applied in the field of drug identification based on terahertz spectrum, can solve the problems of low spectral stability, poor classification effect of similar drugs, large individual differences of similar drugs, etc., and achieve the effect of good generalization performance.

Active Publication Date: 2021-02-19
SHANDONG ACAD OF SCI INST OF AUTOMATION
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this stage, drug detection methods based on terahertz spectral analysis are generally based on the analysis of optical parameters in the full frequency band. Due to the low spectral stability of drug testing in certain frequency bands and the large individual differences of similar drugs, the classification effect of the model on similar drugs Difference

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Terahertz spectrum-based drug identification method
  • Terahertz spectrum-based drug identification method
  • Terahertz spectrum-based drug identification method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] Preferably, in step (1), the sample preparation method at least includes the steps of drying and tableting: drying the drug powder to be measured and then compressing into tablets to obtain the sample.

[0037] Further, the particle size of the drug powder is 100 mesh or less. Controlling the particle size of the drug powder can reduce the influence of drug particle scattering on the terahertz wave, and at the same time facilitate tablet making and reduce labor intensity.

[0038] In some specific embodiments, the drug powder is a traditional Chinese medicine glue powder. Since the glue itself is viscous, no additional binder is needed when tableting based on the tableting method provided by the present invention. The advantages of doing so are at least Two points: first, the material cost of the test is reduced; second, to prevent the insufficient mixing of the binder and the drug powder from affecting the accuracy of the test result.

[0039] Further, the drying is c...

Embodiment 1

[0085] In this embodiment, donkey hide glue, cowhide glue and pig hide glue are classified. Since the finished glue is usually in the form of a block, the thickness cannot meet the needs of the current terahertz spectrum test. Some crushing devices have requirements for the size of the initial feed of the block, so it needs to be crushed; the purpose of grinding and screening is to obtain a sufficient particle size. Small and uniform powder, easy to form into tablets; the purpose of constant temperature dehydration is to reduce the absorption of water on terahertz waves and reduce the impact of environmental variables; The shape of the sheet is convenient for terahertz spectroscopy. The shape of the sample after grinding and tableting is as follows figure 1 shown.

[0086] In this embodiment, a mold with a smaller diameter (about 1 cm) is used to complete the tablet compression, and the pressure is controlled at 10 MPa. This has several advantages: first, the tablet compressio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a terahertz spectrum-based drug identification method, which comprises the following steps of tabletting drug powder, measuring to obtain a terahertz spectrum of the drug powder, extracting optical parameters, dividing the optical parameters into a plurality of sub-frequency bands, performing dimension reduction on the optical parameters of each sub-frequency band through amulti-dimensional scale method, and constructing a convex hull, regarding the number of the other type of sample points in a certain type of sample convex hulls as convex hull statistics, and optimizing the corresponding frequency band and optical parameters when the numerical value reaches the minimum, and constructing a linear classification model in the optimal frequency band, realizing attribution discrimination of unknown samples to the two types, and determining the drug type based on voting results of a plurality of linear dichotomy models under each optimal frequency band. The method is free of chemical reagents and reactions, effective utilization of full-band optical parameters is achieved, and the generalization performance of the model is good.

Description

technical field [0001] The invention belongs to the technical field of drug identification, and in particular relates to a drug identification method based on terahertz spectroscopy. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] "The Pharmacopoeia of the People's Republic of China" includes a variety of traditional Chinese medicine gels as legal standards. Their raw materials and preparation processes are similar, but there are differences in curative effects. Due to the different degrees of difficulty in obtaining drug raw materials and different processing techniques, the market prices of different glues are quite different. Therefore, there is an illegal phenomenon o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/3581G01N21/3563G06K9/62
CPCG01N21/3581G01N21/3563G06F18/2431G06F18/2411
Inventor 李羿璋常天英刘陵玉张献生李珂徐文青崔洪亮
Owner SHANDONG ACAD OF SCI INST OF AUTOMATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com