Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of alcohol extract of flos lonicerae, herba artemisiae and fructus gardeniae prescription

A technology of alcohol extraction and honeysuckle cyanine, which is applied in the field of medicine to achieve the effect of improving the degree of necrosis, improving neuron degeneration and necrosis, and improving survival rate

Inactive Publication Date: 2021-03-09
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report about YQZ anti-A6 type Coxsackievirus (CV-A6)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of alcohol extract of flos lonicerae, herba artemisiae and fructus gardeniae prescription
  • Preparation method and application of alcohol extract of flos lonicerae, herba artemisiae and fructus gardeniae prescription
  • Preparation method and application of alcohol extract of flos lonicerae, herba artemisiae and fructus gardeniae prescription

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Alcoholic Extract of Artemisia annua and Gardeniae Fang:

[0033] Grind honeysuckle, Artemisia annua and Gardenia separately, pass through a 60-mesh sieve, weigh 300g of honeysuckle, 1500g of Artemisia annua, and 200g of Gardenia, add 8 times the amount of 55% ethanol, soak for 2 hours, ultrasonically at room temperature for 20 minutes, extract twice; filter, Combine the filtrates, recover the ethanol under reduced pressure at 40°C to obtain the crude extract; pre-freeze the crude extract at -70°C for 2 hours, freeze-dry at the pressure of -30Pa and temperature of -45°C for 48 hours, and pulverize to obtain the product.

Embodiment 2

[0034] Example 2 Preparation of Alcoholic Extract of Artemisia annua and Gardeniae Fang:

[0035] Grind honeysuckle, Artemisia annua and Gardenia separately, pass through a 60-mesh sieve, weigh 300g of honeysuckle, 1500g of Artemisia annua, and 200g of Gardenia, add 8 times the amount of 75% ethanol, soak for 2 hours, ultrasonically at room temperature for 20 minutes, extract twice; filter, Combine the filtrates, recover the ethanol under reduced pressure at 40°C to obtain the crude extract; pre-freeze the crude extract at -70°C for 2 hours, freeze-dry at the pressure of -30Pa and temperature of -45°C for 48 hours, and pulverize to obtain the product.

Embodiment 3

[0036] Example 3 Preparation of Alcoholic Extract of Artemisia annua and Gardeniae Fang:

[0037]Grind honeysuckle, Artemisia annua and Gardenia separately, pass through a 60-mesh sieve, weigh 300g of honeysuckle, 1500g of Artemisia annua, and 200g of Gardenia, add 8 times the amount of 75% ethanol, soak for 2 hours, ultrasonically at room temperature for 20 minutes, extract twice; filter, Combine the filtrates, recover the ethanol under reduced pressure at 40°C to obtain the crude extract; pre-freeze the crude extract at -70°C for 2 hours, freeze-dry at the pressure of -30Pa and temperature of -45°C for 48 hours, and pulverize to obtain the product.

[0038] Through the experimental example, the pharmacological test of the alcohol extract of Yinhua Qinghao Zhizi prescription is carried out, the details are as follows:

[0039] 1.1 Medicinal materials

[0040] The medicinal material of honeysuckle is the dried flower bud of Lonicera japonica Thunb.; the medicinal material of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a preparation method and application of an alcohol extract of a flos lonicerae, herba artemisiae and fructus gardeniae prescription. The preparation method comprises the following steps: crushing flos lonicerae, herba artemisiae and fructus gardeniae, sieving the crushed flos lonicerae, herba artemisiae and fructus gardeniae with a 60-mesh sieve, weighing 3 parts of flos lonicerae, 15 parts of herba artemisiae and 2 parts of fructus gardeniae in parts by weight, adding 8 times of 75% ethanol for soaking for 2h, carrying out room-temperature ultrasonic treatment for 20 minutes, and performing extracting twice; performing filtering, merging filtrates, and recovering ethanol under reduced pressure at 40 DEGC to obtain a crude extract; and pre-freezing the crude extract at 70 DEG C for 2h, performing freeze-drying at the pressure of -30 Pa and the temperature of 45 DEG C for 48h, and performing crushingto obtain the alcohol extract. The alcohol extract of the flos lonicerae, herba artemisiae and fructus gardeniae prescription disclosed by the invention has good in-vitro and in-vivo anti-Coxsackievirus A6 effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of an alcoholic extract of Artemisia annua and Gardenia jasminoides. Background technique [0002] Yinhua Qinghao Gardenia Prescription (YQZ) is derived from the experience of famous old Chinese medicine practitioners. The prescription consists of honeysuckle, Artemisia annua and Gardenia. This prescription has been successfully developed into traditional Chinese medicine preparations such as Reduning injection, which is widely used in the treatment of upper respiratory tract infection (exogenous wind-heat syndrome), and has achieved good social and economic benefits. [0003] Patent CN101721515A discloses the application of a traditional Chinese medicine composition composed of artemisia annua, gardenia and honeysuckle in the preparation of medicines for treating hand-mouth-foot disease. It is mentioned in the patent that Reduni...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/744A61P9/00A61P11/00A61P21/00A61P25/00A61P31/14A61K36/355A61K36/282
CPCA61K36/282A61K36/355A61K36/744A61K2236/333A61K2236/51A61P9/00A61P11/00A61P21/00A61P25/00A61P31/14A61K2300/00
Inventor 李菲田景振
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com