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Application of echinacoside in preparation of medicine for treating neuropathic pain

A technology for echinacoside, neuropathy, used in pain medicine and natural medicinal chemistry

Active Publication Date: 2021-03-16
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on the protective effect of echinacoside on neuropathic pain.

Method used

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  • Application of echinacoside in preparation of medicine for treating neuropathic pain
  • Application of echinacoside in preparation of medicine for treating neuropathic pain
  • Application of echinacoside in preparation of medicine for treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The use of echinacoside in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of echinacoside is 50 mg / kg for mice, and the dosage form of the medicine is oral dosage form.

Embodiment 2

[0033] The use of echinacoside in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of echinacoside is 100 mg / kg for mice, and the dosage form of the medicine is oral dosage form.

Embodiment 3

[0035] The use of echinacoside in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of echinacoside is 200 mg / kg for mice, and the dosage form of the medicine is oral dosage form.

[0036] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0037] 1. Experimental materials

[0038] 1.1 Animal handling

[0039] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0040] 1.2 Experimental drugs and instruments

[0041] Echinacoside (Zhongke Qu...

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PUM

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Abstract

The invention discloses an application of echinacoside (ECH) in preparation of a medicine for treating neuropathic pain. Experimental results show that when the ECH is used in a safe dosage range, theECH with the dosage of 200 mg / kg can remarkably relieve allodynia and hyperalgesia induced by a sciatic nerve chronic compression injury model, improve histopathological changes of sciatic nerves andregulate protein expression of inflammatory cytokines; and it is proved that the ECH has the effects of relieving the neuropathic pain caused by chronic compression injury and promoting the neural functional recovery.

Description

technical field [0001] The invention relates to the fields of analgesic medicine and natural medicinal chemistry, and specifically, the application provides the use of echinacoside in preparing medicine for treating neuropathic pain. Background technique [0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (eg, diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (eg, stroke), nerve compression, nerve trauma, and cancer, among others. Neuropathic pain plagues 1 / 6 of the world's people, not only causing physical pain and dysfunction, but also accompanied by depression, anxiety and other psychological and mental disorders, which have a serious impact on patients' life and quality of life, and give A huge burden on the family and society. In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P25/02A61P19/02A61P25/00A61P29/00
CPCA61K31/7032A61P25/02A61P19/02A61P25/00A61P29/00Y02A50/30
Inventor 余建强张国鑫刘宁朱春浩杨佳美马琳田苗苗
Owner NINGXIA MEDICAL UNIV
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