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Pharmaceutical purpose of liquirtin treating neuropathic pain

A technology of liquiritin and neuropathy, which is applied in the field of liquiritin in the preparation of medicines for the treatment of neuropathic pain, can solve the problem that the protective effect of neuropathic pain has not been reported in the literature, and can increase the nerve conduction velocity and sensory nerve action potential amplitude, promote The effect of expressing and relieving mechanical hyperalgesia

Active Publication Date: 2017-11-24
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies at home and abroad have found that liquiritin also has various pharmacological activities and clinical functions such as anti-inflammatory, neuroprotective, and antidepressant effects, but there is no literature report on its protective effect on neuropathic pain.

Method used

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  • Pharmaceutical purpose of liquirtin treating neuropathic pain
  • Pharmaceutical purpose of liquirtin treating neuropathic pain
  • Pharmaceutical purpose of liquirtin treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0030] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 30 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

Embodiment 2

[0032] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0033] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 60 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

Embodiment 3

[0035] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0036] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 120 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

[0037] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0038] 1. Experimental materials

[0039] 1.1 Animal handling

[0040] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2013-0005. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0041] 1.2 Experimental drugs and instruments

[0042] Liquiritin (Beijing Zhongke Quality Ins...

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Abstract

The invention discloses a purpose of liquirtin in preparing drugs for treating neuropathic pain. The experimental result of the purpose of the liquirtin in preparing the drugs for treating the neuropathic pain shows that when being used within a safe dose range, the liquirtin with the dose being 120 mg / kg can obviously relieve pain allodynia and hyperalgesia which are induced by a model of chronic constriction injury of sciatic nerve, the histopathologic change of the sciatic nerve is improved and protein expression of inflammatory cytolines is regulated and controlled, and it is proved that the liquirtin has the effects of relieving the neuropathic pain caused by mice chronic constriction injury and promoting neural functional recovery.

Description

technical field [0001] The invention relates to the application of liquiritin, in particular to the use of liquiritin in the preparation of medicines for treating neuropathic pain. Background technique [0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (such as diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (such as stroke), nerve compression, nerve trauma, and cancer, etc. Neuropathic pain plagues 1 / 6 of the world's people, not only causing physical pain and dysfunction, but also accompanied by depression, anxiety and other psychological and mental disorders, which have a serious impact on patients' life and quality of life, and give A huge burden on the family and society. In recent years, with the rapid development of pathology,...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P29/00A61P25/00A61P25/02
CPCA61K31/7048
Inventor 余建强张梦婷李玉香刘宁赵玉萍
Owner NINGXIA MEDICAL UNIV
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