Application of nobiletin in preparation of medicine for treating neuropathic pain

Abstract

The invention discloses an application of nobiletin (NOB) in preparation of a medicine for treating neuropathic pain. Experimental results show that when the traditional Chinese medicine composition is used in a safe dosage range, hyperalgesia hypersensitivity and hyperalgesia induced by a sciatic nerve chronic compression injury model can be remarkably relieved, histopathologic changes of sciatic nerves are improved, and expression of pain related factors is regulated and controlled; the nobiletin is proved to have the functions of relieving neuropathic pain caused by chronic compression injury and promoting neurological function recovery.

Description

technical field

[0001] The invention relates to the field of neurological disease treatment. Specifically, the application relates to the application of nobiletin, in particular to the use of nobiletin in the preparation of medicines for treating neuropathic pain. Background technique

[0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (eg, diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (eg, stroke), nerve compression, nerve trauma, and cancer, among others. Neuropathic pain plagues 1 / 6 of the people in the world. It not only causes physical pain and dysfunction, but also is accompanied by depression, anxiety and other psychological and mental disorders, which has a serious impact on the life and quality of life of the patient, and br...

Examples

Embodiment 1

[0037] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 30 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 2

[0039] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 60 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 3

[0041] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 120mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

[0042] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0043] 1. Experimental materials

[0044] 1.1 Animal handling

[0045] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0046] 1.2 Experimental drugs and instruments

[0047] Nobiletin (Shanghai Yuanye Biot...

technical field

[0001] The invention relates to the field of neurological disease treatment. Specifically, the application relates to the application of nobiletin, in particular to the use of nobiletin in the preparation of medicines for treating neuropathic pain. Background technique

[0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (eg, diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (eg, stroke), nerve compression, nerve trauma, and cancer, among others. Neuropathic pain plagues 1 / 6 of the people in the world. It not only causes physical pain and dysfunction, but also is accompanied by depression, anxiety and other psychological and mental disorders, which has a serious impact on the life and quality of life of the patient, and br...

Examples

Embodiment 1

[0037] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 30 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 2

[0039] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 60 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 3

[0041] The use of nobiletin in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of nobiletin is 120mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

[0042] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0043] 1. Experimental materials

[0044] 1.1 Animal handling

[0045] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0046] 1.2 Experimental drugs and instruments

[0047] Nobiletin (Shanghai Yuanye Biot...

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