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Application of anethole in preparing drug for treating neuropathic pain

A technology for anethole and neuropathy, which is applied in the field of the use of anethole in the preparation of medicines for treating neuropathic pain, can solve the problem that the protective effect of neuropathic pain has not been reported in literature and the like, and can increase the amplitude of sensory nerve action potential and increase nerve conduction. Speed, expression-promoting effect

Active Publication Date: 2018-10-26
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies at home and abroad have proved that anethole has anti-inflammatory, analgesic, anti-oxidant, anti-diabetic metabolic abnormalities, immune regulation and neuroprotective pharmacological effects, but there is no literature report on its protective effect on neuropathic pain.

Method used

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  • Application of anethole in preparing drug for treating neuropathic pain
  • Application of anethole in preparing drug for treating neuropathic pain
  • Application of anethole in preparing drug for treating neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The use of anethole in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of anethole is 125 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 2

[0036] The use of anethole in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of anethole is 250 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 3

[0038] The use of anethole in the preparation of medicines for treating neuropathic pain, wherein the neuropathic pain is neuropathic pain caused by peripheral injury, the single application dose of anethole is 500 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

[0039] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0040] 1. Experimental materials

[0041] 1.1 Animal handling

[0042] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2015-0001. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, place the animals in the experimental environment for acclimatization 3 .

[0043] 1.2 Experimental drugs and instruments

[0044]Anethole (Shanghai Yuanye Biotechn...

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Abstract

The invention discloses application of anethole in preparing a drug for treating neuropathic pain. Experiment results of the invention show that when being used within a safe dose range, the anetholewith the dose being 500mg / kg can remarkably relieve pain hypersensitivity and hyperpathia induced by a model of chronic constriction injury of sciatic nerves, improves histopathological changes of thesciatic nerves and regulates protein expression of inflammatory cytokines, and prove that the anethole has the effects of relieving the neuropathic pain caused by chronic constriction injury and promoting neural functional recovery.

Description

technical field [0001] The invention relates to the application of anethole, in particular to the application of anethole in the preparation of medicines for treating neuropathic pain. Background technique [0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (such as diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (such as stroke), nerve compression, nerve trauma, and cancer, etc. Neuropathic pain plagues 1 / 6 of the world's people, not only causing physical pain and dysfunction, but also accompanied by depression, anxiety and other psychological and mental disorders, which have a serious impact on patients' life and quality of life, and give A huge burden on the family and society. In recent years, with the rapid development of pathol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/085A61P25/00A61P25/02
CPCA61P25/00A61P25/02A61K31/085
Inventor 余建强王冰刘宁李玉香杜鹃谭焕然
Owner NINGXIA MEDICAL UNIV
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