Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical use of liquiritin in the treatment of neuropathic pain

A technology of liquiritin and neuropathy, which is applied in the field of preparation of liquiritin to treat neuropathic pain. It can solve the problems that the protective effect of neuropathic pain has not been reported in the literature, so as to increase the nerve conduction velocity and the amplitude of sensory nerve action potential, and promote Expressing, alleviating effects of mechanical hyperalgesia

Active Publication Date: 2020-08-04
NINGXIA MEDICAL UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies at home and abroad have found that liquiritin also has various pharmacological activities and clinical functions such as anti-inflammatory, neuroprotective, and antidepressant effects, but there is no literature report on its protective effect on neuropathic pain.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical use of liquiritin in the treatment of neuropathic pain
  • Pharmaceutical use of liquiritin in the treatment of neuropathic pain
  • Pharmaceutical use of liquiritin in the treatment of neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0030] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 30 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

Embodiment 2

[0032] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0033] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 60 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

Embodiment 3

[0035] The use of liquiritin as a drug for the treatment of neuropathic pain,

[0036] Wherein, neuropathic pain is neuropathic pain caused by peripheral injury, a single application dose of liquiritin is 120 mg / kg for mice, and the dosage form of the drug is an oral dosage form.

[0037] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0038] 1. Experimental materials

[0039] 1.1 Animal handling

[0040] Male ICR mice, 18-22g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2013-0005. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12 hours each. Before the experiment, the animals were placed in the experimental environment for 3 days to adapt.

[0041] 1.2 Experimental drugs and instruments

[0042] Liquiritin (Beijing Zhongke Quality Ins...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a purpose of liquirtin in preparing drugs for treating neuropathic pain. The experimental result of the purpose of the liquirtin in preparing the drugs for treating the neuropathic pain shows that when being used within a safe dose range, the liquirtin with the dose being 120 mg / kg can obviously relieve pain allodynia and hyperalgesia which are induced by a model of chronic constriction injury of sciatic nerve, the histopathologic change of the sciatic nerve is improved and protein expression of inflammatory cytolines is regulated and controlled, and it is proved that the liquirtin has the effects of relieving the neuropathic pain caused by mice chronic constriction injury and promoting neural functional recovery.

Description

technical field [0001] The invention relates to the application of liquiritin, in particular to the use of liquiritin in the preparation of medicines for treating neuropathic pain. Background technique [0002] Neuropathic pain (neuropathic pain) is a chronic pain syndrome, its pathogenesis is more complex, generally due to the abnormal function of the nervous system or damage to the pain, common in autoimmune diseases (such as multiple sclerosis), Metabolic disease (such as diabetic neuropathy), infection (postherpetic neuralgia), vascular disease (such as stroke), nerve compression, nerve trauma, and cancer, etc. Neuropathic pain plagues 1 / 6 of the world's people, not only causing physical pain and dysfunction, but also accompanied by depression, anxiety and other psychological and mental disorders, which have a serious impact on patients' life and quality of life, and give A huge burden on the family and society. In recent years, with the rapid development of pathology,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P29/00A61P25/00A61P25/02
CPCA61K31/7048
Inventor 余建强张梦婷李玉香刘宁赵玉萍
Owner NINGXIA MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com