Multi-mode mass spectrometry system and method

A mass spectrometry and multi-mode technology, applied in the analysis of materials, material analysis by electromagnetic means, particle separation tubes, etc., can solve problems such as unfavorable dual-mode combinations and affecting ion transmission

Pending Publication Date: 2021-05-14
HANGZHOU PUYU TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is also a built-in electromagnet to drive a micro-valve action to achieve isolation, but the electromagnet requires additional leads, and the magnetic field brought by the magnet may affect ion transmission.
[0007] It can be seen that the existing solutions all have some problems that are not conducive to dual-mode combination

Method used

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  • Multi-mode mass spectrometry system and method
  • Multi-mode mass spectrometry system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]figure 1 Structure of multi-mode mass spectrometry systems, such asfigure 1 As shown, the multi-mode mass spectrometry includes:

[0036]The first ion source 21, the second ion source 22 (e.g., the EI source or CI source) and the multi-stage transmission rod, the multi-stage transmission rod is disposed in a plurality of vacuum chambers in series; the first ion source 21 is atmospheric pressure ion Source, such as an ESI source or APCI source, the exit ion sequentially passes through the first vacuum chamber 12, the second vacuum chamber 13, the second ion source 22 is disposed in the vacuum chamber; the first vacuum chamber 12 and the second vacuum chamber 13 There is a spacer 61 having a first through hole 62 adapted to the ion;

[0037]Such asfigure 2 As shown, the container 91, the container 91 is isolated by the first slider 94 as the first portion 92 and the second portion 93, the first portion 92, in communication, the second truse chamber 13, the second portion 93 communicat...

Embodiment 2

[0056]Application examples of multi-mode mass spectrometry analysis systems and methods according to Embodiment 1 of the present invention.

[0057]In this application example, ifFigure 1-2As shown, the multi-mode mass spectrometry system includes four tandem vacuum chambers, and the three-stage transmission rod is disposed in the first three vacuum chambers (first to third vacuum chains), and the mass analyzer 51 is disposed in the fourth vacuum chamber 15. Inside; there is a spacer between the adjacent vacuum chambers, the spacer has a through hole suitable for ions; wherein the first spacer 61 having the first vacuum chamber 12 and the second vacuum chamber 13 has a first through hole 62. The first ion source 21 employs an ESI source, disposed within the atmospheric pressure ionization chamber 11; the second ion source 22 is provided in the third vacuum chamber 14, and is in the side of the transmission rod 43; ion deflection module setting In the third vacuum chamber 14, the ions e...

Embodiment 3

[0068]According to an application example of a multi-mode mass spectrometry system and method according to Embodiment 1 of the present invention, it is different from Example 1:

[0069]A guide or guide is provided on the first spacer, the second slider moving on the guide or rail, so that the second slider is moving up and down, and the left and right are not missing, and the second pass is guaranteed. Correspondence and communication between the holes and the first through hole.

[0070]The spring is disposed on the upper side of the second slider, and when the second slider moves upward, the spring is compressed, producing a downward elastic force, that is, spring hinders the second slider.

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Abstract

The invention provides a multi-mode mass spectrometry system and method. The multi-mode mass spectrometry system comprises a first ion source, a second ion source and a multi-stage transmission rod, wherein the first ion source is an ion source under atmospheric pressure, a separation piece between a first vacuum chamber and a second vacuum chamber is provided with a first through hole suitable for ions to pass through, the interior of a container is separated into a first part and a second part by a first sliding piece, the first part is communicated with the second vacuum chamber, the second part is communicated with the first vacuum chamber, the first sliding piece sliding in the container is sealed with the inner wall of the container, one end of a connecting piece is connected with the first sliding piece, the other end of the connecting piece penetrates through the second part and is connected with a second sliding piece, the second sliding piece is provided with a second through hole, when the second sliding piece slides on the surface of the separation piece, the second sliding piece seals the first through hole, or the second through hole is communicated with the first through hole, and an elastic piece is connected with the second sliding piece and used for preventing the second sliding piece from moving towards the first part. The multi-mode mass spectrometry system has the advantages of low cost and the like.

Description

Technical field[0001]The present invention relates to mass spectrometry, and more particularly to multi-mode mass spectrometry systems and methods.Background technique[0002]GC-MS, LC-MS is two common mass spectrometry techniques, both of which are complementary, and the MS part is the same, so the GC-LC-MS-MS-MS-MS-formed GC-LC-MS-optimized applications and costs, there is very Large market advantage.[0003]The vacuum requirements for the ion source of the two are different, GC (Ei / CI source) requires a vacuum degree above 1e-5 Torr, and it is necessary to directly block atmospheric pressure; LC (ESI / APCI source) works at the atmosphere, need The atmospheric pressure is transmitted by the transition of the multi-stage vacuum chamber.[0004]For the same problem, Waters use the ion source to replace the problem, and need to be artificially disassembled, and the online switching of GC / LC two modes cannot be realized;[0005]For vacuum partition problems, Hangzhou spent ICP-MS product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62H01J49/10
CPCH01J49/107G01N27/64
Inventor 雷鑫槐俞晓峰韩双来杨继伟胡建坤
Owner HANGZHOU PUYU TECH DEV CO LTD
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