Application of drug combination of vitamin K1 and temozolomide in preparation of medicine for treating cholangiocarcinoma

A technology of temozolomide and combined medication, which is applied in the field of medicine, can solve the problems that have not been reported yet, and achieve the effects of improving anti-tumor effect, reducing dosage, and reducing toxic and side effects
CN112843028AInactive Publication Date: 2021-05-28阿耳法猫(杭州)人工智能生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
阿耳法猫(杭州)人工智能生物科技有限公司
Publication Date
2021-05-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of medicine, and particularly relates to application of a drug combination of vitamin K1 and temozolomide in preparation of a medicine for treating bile duct cancer. The application of the drug combination of the vitamin K1 and the temozolomide in preparation of the medicine for treating the cholangiocarcinoma is provided for the first time, the vitamin K1 and the temozolomide have an obvious synergistic effect, so curative effect is effectively improved; the curative effect of the drug combination is more obvious compared with a single component, and killing performance on tumor cells is improved; dosage is effectively reduced, so toxic and side effects are reduced; and the drug combination can save cost, relieve the economic burden of patients, provide a new way for the prevention and treatment of bile duct cancer, and have wide application prospects in the field of medicine and pharmacology.
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Description

technical field

[0001] The invention belongs to the field of medicine, and particularly relates to the application of vitamin K1 and temozolomide in combination in preparing a medicine for treating cholangiocarcinoma. Background technique

[0002] Cholangiocarcinoma is a malignant tumor originating from bile duct epithelial cells and is the second most common malignant tumor of the hepatobiliary system after liver cancer. The overall mortality of hepatobiliary malignancies ranks fifth among all malignant tumors. my country is a high-incidence area of ​​cholangiocarcinoma, and the incidence has been increasing in recent years. Cholangiocarcinoma is highly aggressive, only 30% to 40% of patients can be effectively treated by surgical resection at the time of diagnosis, while most patients are diagnosed at an advanced stage, lacking effective treatment methods, and the prognosis is extremely poor.

[0003] Temozolomide is a first-line chemotherapeutic drug against malignant g...

Claims

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