Intestinal microbial markers for abdominal aortic aneurysm and application of intestinal microbial marker
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A technology for abdominal aortic aneurysm and gut microbes, applied in the field of gut microbiome markers, can solve the problem that the incidence of abdominal aortic aneurysm cannot be predicted early
Pending Publication Date: 2021-05-28
SHANDONG UNIV QILU HOSPITAL
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However, the relationship between gut microbiota and abdominal aortic aneurysm has not yet been reported, and there is no reliable gut microbial ma
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Embodiment 1
[0071] A classifier modeling evaluation verification method based on the abundance of intestinal microbiota to determine the intestinal microbial markers of abdominal aortic aneurysm, including the following steps:
[0072] 1. Determination of research objects
[0073] The exclusion criteria for abdominal aortic aneurysm patients and healthy subjects were:
[0074] (1) Those suffering from the following diseases: immune system diseases (SLE, arthritis, etc.), tumor diseases, liver cirrhosis, hypothyroidism, hyperthyroidism, peripheral vascular diseases, acute infectious diseases;
[0075] (2) Those who have taken antibiotics in the past two weeks or recently infected, white blood cells, neutrophils, CRP and other inflammatory markers have significantly increased;
[0076] (3) Taking a large amount of other drugs in the past month.
[0077] The information of abdominal aortic aneurysm patient group and healthy person group is shown in Table 1.
[0078] Table 1. Clinical data...
Embodiment 2
[0139] Example 2. Evaluation of the accuracy of the screened intestinal microbial markers in predicting the risk of abdominal aortic aneurysm
[0140] In the test set, the abdominal aortic aneurysm enriched intestinal microbial index (AAAincreased microbial index) and the abdominal aortic aneurysm reduced intestinal microbial index (AAA decreased microbial index) calculated in Example 1 were used as input respectively, and the distribution between the groups Such as Figure 6 As shown, the area under the curve (AUC) of the receiver operating characteristic curve (ROC) was used to evaluate the ability of abdominal aortic aneurysm to enrich intestinal microorganisms and abdominal aortic aneurysm to reduce intestinal microorganisms to abdominal aortic aneurysms, and the results Such as Figure 7 As shown, AUC=0.8856 obtained when abdominal aortic aneurysm enriched intestinal microbial index (AAA increasedmicrobial index) was used as input, and the ability to diagnose and identif...
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Abstract
The invention relates to intestinal microbial markers for abdominal aortic aneurysm and application of the intestinal microbial markers. According to the method, 30 kinds of intestinal microbiological markers of abdominal aortic aneurysm are determined by using a classifier modeling evaluation and verification method based on the abundance of intestinal microbiota, and the determined 30 kinds of intestinal microbiological markers of abdominal aortic aneurysm contains 25 kinds of up-regulated intestinal microbiological markers and 5 kinds of down-regulated intestinal microbiological markers. According to the intestinal microbial markers of the abdominal aortic aneurysm, high-risk groups of the abdominal aortic aneurysm can be effectively and early screened or early patients with the abdominal aortic aneurysm can be found, so further expansion of the abdominal aortic aneurysm is prevented as early as possible, a rupture risk is reduced, and the treatment effect of the abdominal aortic aneurysm is monitored. Meanwhile, the intestinal microbial markers can be used for preparing diagnostic kits and therapeutic drugs. The intestinal microbial markers of the invention overcomes the defects that existing abdominal aortic aneurysm diagnosis cannot achieve early screening and cannot predict the morbidity and development trend of the abdominal aortic aneurysm, etc., and can help pathological typing of the disease, action target research of drugs, accurate medication, pathogenesis research and the like.
Description
technical field [0001] The invention belongs to the technical field of biomedicine, and mainly relates to intestinal microbial markers of abdominal aortic aneurysms and applications thereof. Background technique [0002] Abdominal aortic aneurysm, the most common aneurysm, is a circulatory disease that seriously threatens human health. Abdominal aortic aneurysm (AAA) refers to abnormal or limited expansion of a certain segment of the abdominal aorta, with a transverse diameter > 3 cm or more than 50% of the normal abdominal aortic diameter, which eventually makes the wall unable to bear the blood flow. A high-risk disease that ruptures on impact. The incidence of abdominal aortic aneurysm is increasing year by year, most of which occur in people over the age of 50, especially in men and those with a family history of the disease. Other risk factors include smoking, high blood pressure, coronary heart disease, high cholesterol, peripheral artery disease, high Homocystein...
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