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Microfluidic sample preparation device offering high repeatability

A microfluidic and equipment technology, applied in the field of microfluidic equipment, can solve the problems of bubble measurement results, distortion, loss, etc., and achieve the effect of reducing the risk of bubbles

Pending Publication Date: 2021-06-25
COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the movement of liquids propelled by air requires the management of the air-biofluid interface, which can be tricky
On the other hand, two volumes of liquid are filled and then moved, the accuracy of the dilution will depend on the movement of the two liquids in the coil to mix, and during the movement there may be wetting and dewetting problem, which is likely to result in a partial loss of either of the two fluids
[0007] Also, an air purge is required to avoid any other liquid in the circuit, air bubbles can appear in the mixture and distort the measurement

Method used

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  • Microfluidic sample preparation device offering high repeatability
  • Microfluidic sample preparation device offering high repeatability
  • Microfluidic sample preparation device offering high repeatability

Examples

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Comparison scheme
Effect test

Embodiment Construction

[0057] In the following description, the implemented fluid is a liquid. This description also applies to gaseous fluids.

[0058] exist figure 1 In , a schematic diagram of a device D1 for preparing a liquid solution for analysis according to an exemplary embodiment can be seen.

[0059] The preparation includes, for example, dilution of the sample, processing of some sample components, eg, lysis in the case of blood, or labeling of an aliquot of whole blood with a reagent. For example, analysis of a solution so prepared may include counting constituent elements in the blood, or measuring soluble substances such as hemoglobin after lysis of red blood cells.

[0060] Preferably, the preparation device is designed as a fluidic chip for cooperating with a chip support ensuring pneumatic activation of the chip.

[0061] The preparation device is used to prepare a solution comprising a given volume of a sample (eg, blood) and a given volume of a reagent.

[0062] The preparatio...

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Abstract

Disclosed is a device for preparing a solution from a sample and a reagent, comprising a microfluidic array comprising a sample supply inlet (E1), a reagent supply inlet (E2), a discharge outlet (S1), a solution collection outlet (S2), a sampling zone (ZE) to which the inlets (E1, E2) are connected, first (4) and second (6) preparation chambers connected to the sampling zone (ZE), arranged to either side of the sampling zone (ZE) such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone (ZE), the first preparation chamber (4) having a volume that is variable between a minimum volume and a calibrated volume. The device comprises valves interrupting the flow of the fluid at least at the two inlets (E1, E2) and the collection (S2) and discharge (S1) outlets.

Description

technical field [0001] The present invention relates to a microfluidic device for preparing solutions, such as biological solutions for analysis, with high repeatability and high accuracy in terms of liquid volumes processed. Background technique [0002] In the field of health, especially in the field of medical analysis, the constituent elements of blood (white blood cells, red blood cells and platelets) are diluted and / or processed for hematological analysis. Treatment may include lysis or specific labeling of red blood cells. [0003] These processing operations of blood samples require high accuracy of the volumes processed (eg, accurate knowledge of the concentration after dilution) and high repeatability. [0004] Furthermore, there is a need to reduce the production costs of microfluidic devices. [0005] Devices exist for preparing blood for its analysis that are highly accurate and reproducible, for example, current hematology automatons. These are large devices...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/38B01F13/00B01J19/00B01L3/00B01F11/00B01F15/04G05D11/00G01N35/10
CPCG01F11/28G01N1/38G01N35/1095B01L3/502738B01L2200/0621B01L2300/0816B01L2300/0867B01L2300/087B01L2400/0655B01F31/65B01F33/30B01F35/8823B01L3/50273B01L2300/0681B01L2300/0819B01F35/8822
Inventor Y·弗伊莱特阿内斯·阿里谢里夫
Owner COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
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