Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Detection method of anti-hysteritis soft capsule

A detection method and soft capsule technology, which is applied in the detection field of Kanggongyan soft capsules, can solve the problems that the fingerprints and detection methods of Kanggongyan soft capsules have not been reported, so as to ensure clinical efficacy, strong specificity and stability sex good effect

Pending Publication Date: 2021-06-29
GUIZHOU HUIZHENG PHARMA CO +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only the HPLC fingerprints of Kanggongyan series preparations (tablets, granules, and capsules) have been studied, and the fingerprints and detection methods of Kanggongyan Soft Capsules have not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Detection method of anti-hysteritis soft capsule
  • Detection method of anti-hysteritis soft capsule
  • Detection method of anti-hysteritis soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0058] The present invention will be further described below in conjunction with the examples, but not as a basis for limiting the present invention.

[0059] Example. A detection method for Kanggongyan Soft Capsules, the detection steps are:

[0060] (1) Preparation of mixed reference substance solution: Accurately weigh an appropriate amount of norisoboldine, leonurine hydrochloride, forsythiaside B, verbascoside, aureoside, and isobrascoside, put them in a volumetric flask, and add 50% Dissolve in methanol and shake well to obtain norisoboldine with a concentration of 16.0-52.0 μg / ml; 5.0-175.0 μg / ml of leonurine hydrochloride; 4.0-146.0 μg / ml of verbascoside; 5.0-168.0 μg / ml of aureoside; 5.0-175.0 μg / ml of different verbascoside series concentration gradient reference substance mixed solution; the concentration gradient is 2-25 μg / ml For a gradient, more than 5 gradient concentrations are prepared for each substance; for example, 4.0-150.0 μg / ml forsythiaside B referenc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a detection method of an anti-hysteritis soft capsule. The method comprises the following steps: (1) preparing a mixed reference substance solution; (2) setting UPLC chromatographic conditions of the anti-hysteritis soft capsule; (3) preparing a test solution; and (4) feeding the test solution according to the chromatographic conditions provided in the step (2), measuring the peak areas of the six components, and calculating according to the standard curve to obtain the contents of the six components in the anti-hysteritis soft capsule. The method disclosed by the invention has the advantage that the accuracy of determining the contents of the six anti-hysteritis soft capsules, namely norisoboldine, leonurine hydrochloride, forsythiaside B, verbascoside, poliumoside and isoacteoside, can be ensured; and the UPLC fingerprint spectrum of the anti-hysteritis soft capsule also has the advantages of rapidness, simplicity, convenience, stability, high precision, good stability, good repeatability and the like.

Description

technical field [0001] The invention relates to the technical field of Kanggongyan soft capsules, in particular to a detection method for Kanggongyan soft capsules. Background technique [0002] Kanggongyan Soft Capsule is a nine-class new drug of traditional Chinese medicine derived from Kanggongyan Tablet. It is composed of Guangdong Zizhu dry extract, Motherwort dry extract and Wuyao dry extract. Blood stasis, heat-clearing and detoxifying effects; motherwort has the effects of promoting blood circulation and regulating menstruation, diuresis, reducing swelling, clearing heat and detoxifying; black medicine has the effects of promoting qi and relieving pain, warming kidney and dispelling cold. The series of preparations of anti-uterine inflammation have remarkable medicinal effects, and have the effects of clearing away heat, removing dampness, removing blood stasis, and stopping leucorrhea. They are mainly used for leukorrhea caused by damp-heat betting. [0003] At pre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8634
Inventor 高秀丽张敏王鹏娇罗伟张硕袁敏艳
Owner GUIZHOU HUIZHENG PHARMA CO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com