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Methyl donor composition for improving sperm quality

A methyl donor and sperm quality technology, applied in the field of medicine, can solve problems such as sperm quality decline

Active Publication Date: 2021-07-06
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The methyl donor composition of the present invention can increase sperm count and sperm motility at the same time, especially when used together with serotonin reuptake inhibitors (SSRIs), it can overcome or even reverse the problem of sperm quality decline caused by SSRIs

Method used

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  • Methyl donor composition for improving sperm quality
  • Methyl donor composition for improving sperm quality
  • Methyl donor composition for improving sperm quality

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] In some specific embodiments of the present invention, when the dosage form of the methyl donor composition or the combination composition is a tablet, the preparation method includes the following preparation steps:

[0050] (1) Pass 5-methyltetrahydrofolate or a pharmaceutically acceptable salt thereof, a betaine compound or a pharmaceutically acceptable salt thereof, and optional serotonin reuptake inhibitors through a 100-mesh sieve respectively, and set aside ;

[0051] (2) 5-methyltetrahydrofolate or a pharmaceutically acceptable salt thereof, a betaine compound or a pharmaceutically acceptable salt thereof, optional 5-hydroxytryptamine reuptake inhibitors, starch, microcrystalline cellulose , sodium carboxymethyl starch (CMS-Na) and magnesium stearate are weighed according to the prescription quantity;

[0052] (3) Mixing: 5-methyltetrahydrofolate or a pharmaceutically acceptable salt thereof, a betaine compound or a pharmaceutically acceptable salt thereof, opt...

Embodiment 1

[0062] Example 1: Improvement of Sperm Quality by Methyl Donor Compositions

[0063] A number of adult male Kunming mice (weight 26-28g, SPF grade, purchased from Liaoning Changsheng Biotechnology Co., Ltd.) were randomly divided into 10 groups with 10 mice in each group, which were blank control group and folic acid administration group respectively. , 5-methyltetrahydrofolate administration group, betaine administration group, folic acid+betaine administration group, 5-methyltetrahydrofolate+betaine administration group, fluoxetine administration group, sertraline Administration group, fluoxetine+5-methyltetrahydrofolate+betaine administration group, sertraline+folic acid+betaine administration group.

[0064] The administration method of each group is as follows:

[0065] Blank control group: normal feed and normal drinking water, free to eat and drink, gavage the same amount of distilled water every day, once a day; continuous for 45 days.

[0066] Administration group: ...

Embodiment 2

[0086] Embodiment 2: the synergistic effect of different concentration combinations

[0087] Carry out test similarly with embodiment 1, difference is to select different concentrations of 5-methyltetrahydrofolate, betaine and combinations thereof, the results are shown in the following table 2:

[0088] Table 2:

[0089]

[0090]

[0091] From the above results, it can be seen that at low concentrations, 5-methyltetrahydrofolate and betaine tend to be synergistic in increasing sperm count or improving sperm motility; The synergistic effect is suppressed, or even antagonized. Therefore, low concentrations of 5-methyltetrahydrofolate and betaine are sufficient to produce the desired effect. However, high concentrations of 5-methyltetrahydrofolate and betaine still contribute to higher sperm counts and higher sperm motility.

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Abstract

The invention relates to a methyl donor composition for improving sperm quality. The composition comprises 5-methyltetrahydrofolic acid and betaine. The invention further relates to a combined composition comprising a 5-selective serotonin reuptake inhibitor and having a function of improving the sperm quality, and the combined composition comprises the 5-selective serotonin reuptake inhibitor, and a composition of the 5-methyltetrahydrofolic acid and betaine. The composition provided by the invention not only can effectively overcome the side effect of reducing the sperm quality when the 5-selective serotonin reuptake inhibitor is applied as a premature ejaculation treatment medicine, but also has a synergistic effect with the 5-selective serotonin reuptake inhibitor in the aspect of preventing or treating depression.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a methyl donor composition for improving the quality of male sperm, and also relates to a pharmaceutical composition comprising the methyl donor composition and a 5-hydroxytryptamine reuptake inhibitor. Background technique [0002] Premature ejaculation (PE) is a common sexual dysfunction, which belongs to ejaculation disorder. Due to the accelerated pace of modern life and the increasing pressure from all aspects, premature ejaculation is more and more common among the male population in our country. Premature ejaculation will not only affect the quality of sexual life, but also affect the couple's life as time goes by, causing patients' mental anxiety, tension, fear, etc., and these bad mental states will further aggravate PE, and gradually make patients lose confidence and spirit. Sluggishness seriously affects the quality of life and work of patients, and has g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/519A61K31/205A61K31/138A61P15/08A61P15/10A61P15/00A61P25/24
CPCA61K45/06A61K31/519A61K31/205A61K31/138A61P15/08A61P15/10A61P15/00A61P25/24A61K2300/00
Inventor 杨卓理苏小楠
Owner 北京斯利安药业有限公司
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