8 results about "Sperm counts" patented technology

The invention discloses application of exosome-like nanoparticles derived from fructus lycii to preparation of a medicine for preventing or treating oligospermia and / or asthenospermia. Sterile, stable and high-purity fructus lycii exosome-like nanoparticles (LBELNs) are obtained by adopting a differential centrifugation-suction filtration-ultra-high-speed centrifugation method, the physiological efficacy of the LBELNs is researched, and it is found that the LBELNs can significantly improve the oligoasthenospermia disease activity index of male mice induced by cyclophosphamide (CTX); the sperm quantity is obviously increased, the sperm malformation is improved, the sperm motility is improved, and the sex hormone level is recovered. The LBELNs can effectively relieve spermatogenic dysfunction of testicular tissues, the sperm differentiation and formation process is obviously improved, the total number of sperms is increased, and the treatment effect is more obvious along with increase of the dosage of the LBELNs. The invention has potential in preparation of drugs for preventing or treating oligoasthenospermia, and provides a new strategy and treatment method for treating oligoasthenospermia.

The present application provides use of compounds represented by formula (I) and formula (II) in the preparation of drugs for improving male reproductive ability. In the present application, different oligoasthenospermia models are constructed, and the improvement effects of the compounds represented by formula (I) and formula (II) on male reproductive ability impairment are verified by means of sperm count analysis, sperm motility analysis, mRNA expression level analysis of inflammatory and antioxidant genes, testicular histopathological damage analysis, etc. The experimental results show that the compounds represented by formula (I) and formula (II) increase the sperm count in mice with oligoasthenospermia, improve the sperm motility of the mice with oligoasthenospermia, ameliorate testicular histopathological damage in the mice, suppress the expression of inflammatory factors, and increase the expression of antioxidant genes, demonstrating great potential in the treatment of oligoasthenospermia.

The invention discloses a traditional Chinese medicine composition for treating infertility, which is prepared from the following raw materials: radix rehmanniae recen, radix paeoniae alba, turtle shell, cortex moutan, peach kernel, ginseng, radix glehniae, medlar, oyster, rhizoma cyperi, radix curcumae, astragalus membranaceus, angelica sinensis, rhizoma anemarrhenae, golden cypress, lotus seed, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, chicken's gizzard-membrane, radix bupleuri, tetrapanax papyriferus, donkey-hide gelatin, eucommia ulmoides and deer glue. Spleen tonifying, blood nourishing, phlegm reducing and dampness clearing; the effects of soothing liver-qi stagnation, promoting qi and activating blood are achieved; qi is benefited, blood is nourished, and Zhongzhou is promoted to regenerate Qi and blood; promoting blood circulation to remove blood stasis and dredging Chong and Ren qi; the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, eliminating dampness and reducing phlegm, can achieve sufficient qi and blood of liver and kidney and smooth Chong and Ren channels, has a good treatment effect on male and female infertility caused by various reasons, and is particularly suitable for female infertility caused by kidney deficiency, weakness, fallopian tube blockage, cold uterus, kidney deficiency type ovulation disorder, obesity, stasis, weakness, blood deficiency and the like; and the traditional Chinese medicine composition is also suitable for male infertility caused by cold sperm, rare sperm, oligospermia and necrospermia due to kidney deficiency.

The utility model provides a sperm counting plate with double sperm counting chambers, which belongs to the technical field of sperm counting plates and comprises a bottom plate, the top of the bottom plate is provided with a first counting chamber and a second counting chamber, two sperm samples can be simultaneously accommodated for detection operation, and the problem that a traditional counting plate cannot simultaneously process a plurality of sperm samples is solved. Bearing assemblies are arranged at the bottoms of the first counting chamber and the second counting chamber, each bearing assembly comprises a counting bottom plate, the bottoms of the first counting chamber and the second counting chamber are detachably connected with the counting bottom plates, and objective tables for bearing sperm samples are arranged at the tops of the counting bottom plates; after detection is completed, the counting bottom plate can be detached and cleaned, meanwhile, the other counting chamber can continue to work, the detection process does not need to be interrupted, protection assemblies are arranged at the tops of the first counting chamber and the second counting chamber, each protection assembly comprises a cover plate, and the cover plates are detachably installed at the tops of the first counting chamber and the second counting chamber.

A medical magnifying lens comprises a focusing module, a sperm counting chamber assembly, an optical lens, a light source circuit board and a main control circuit board which are arranged in an upper shell and a lower shell, a lifting shaft in the focusing module ascends and descends through transmission between a focusing gear and a first transmission gear, then the sperm counting chamber assembly is driven to ascend and descend, the focusing action is achieved, imaging is clear, and the imaging precision is high. The visual field range is adjustable, the visual field content can be observed through a mobile phone camera, the focusing assembly is additionally provided with a second transmission gear, the focusing assembly can be fully and flexibly matched with the space of the lower shell, the structure is compact, and the focusing stability is improved by limiting a first transmission gear and a lifting shaft; the magnifying lens is additionally provided with the liquefaction assembly, so that sample liquefaction, sample slide glass manufacturing and visual field observation can be realized, and the magnifying lens is complete in function, small in overall design, simple and easy to operate, easy to learn, high in functional stability and convenient to carry outside.

The application relates to the field of animal breeding technology, in particular to a method and system for detecting total live sperm count of a cow and application. The method comprises the following steps: based on the genome version ARS-UCD1.2, the methylation level of a region such as chr17:62205563-63205744 of a to-be-detected cow is detected; the detection result is compared with a reference standard, and the total live sperm count of the to-be-detected cow is obtained; the reference standard is obtained based on GWAS correlation data of the total live sperm count and the methylation level of a reference cow group in the region of chr17:62205563-63205744. A region significantly related to the total live sperm count of the cow is obtained through research, early identification of the total live sperm count of the cow can be realized by detecting the methylation level of the region, and this has important significance in the field of animal phenotype identification.

The invention provides application of a compound shown in a formula (I) in preparation of a medicine for improving male reproductive capacity. According to the application, a nano micro-plastic and plasticizer induced Kunming mouse environment pollution type oligospermia and asthenospermia model, a streptozotocin induced Kunming mouse diabetes type oligospermia and asthenospermia model and a sodium valproate induced Kunming mouse anti-epileptic drug type oligospermia and asthenospermia model are respectively constructed; the improvement effect of the compound shown in the formula (I) on male reproductive capacity damage is verified through sperm counting analysis, sperm motility analysis, inflammation and antioxidant gene mRNA expression level analysis, testis tissue pathological damage analysis and the like, and experimental results show that the compound shown in the formula (I) increases the sperm number of mice suffering from oligospermia and asthenospermia, and has a good application prospect. According to the application, the sperm motility of mice with oligospermia and asthenozoospermia is improved, the tissue pathological damage of the testis is improved, the expression of inflammatory factors is inhibited, the expression of antioxidant genes is increased, and the application has great potential in the aspect of treating oligospermia and asthenozoospermia.

The present disclosure describes methods of reducing the likelihood of conception following intercourse between a male subject and a female subject, methods of producing reversible infertility in a male subject, methods of reducing sperm count in a male subject, and methods of selectively antagonizing RAR alpha over RAR beta and RAR gamma in a subject.