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Tumor tissue targeting lipid derivative preparation method

A technology of lipid derivatives and tumor tissue, which is applied in the direction of antineoplastic drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low targeting efficiency and poor selectivity, and reduce the Preparation cost, enhancement of specificity accumulation, effect of improving immunity

Inactive Publication Date: 2021-07-13
苏州合疗生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary liposomes are easily recognized by opsonins and phagocytized by other monocyte-macrophage systems other than viscera, which has the problems of poor selectivity and low targeting efficiency

Method used

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Embodiment Construction

[0023] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0024] In the following description, many specific details are set forth in order to fully understand the present invention, but the present invention can also be implemented in other ways different from those described here, therefore, the protection scope of the present invention is not limited by the specific implementation disclosed below. Example limitations.

[0025] In the description of the present invention, it should be understood that, in order to facilitate the description of the present invention and simplify the descri...

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Abstract

The invention discloses a tumor tissue targeting lipid derivative preparation method which comprises: dissolving a lipid mixture in water, and carrying out vibration treatment on the aqueous solution to form a transparent lipid carrier solution, wherein the lipid carrier solution is transparent; adjusting the lipid carrier solution to 25-35 DEG C, and placing the lipid carrier solution in a closed container; raising the temperature of the transparent lipid carrier solution from 25-35 DEG C to a temperature close to the major phase transition temperature of the transparent lipid carrier solution while mechanically oscillating the closed container containing the transparent lipid carrier solution to form the lipid derivative in the closed container. Compared with other drug delivery carriers, the liposome has remarkable advantages, the systemic toxicity is reduced, the specific accumulation of solid tumors can be enhanced due to the proper particle size, and the sustained release of drugs can be enhanced due to the structural flexibility. The targeted medicine realizes orientation at the dirty part, and improves the immunity of the human body, so that the purposes of enhancing the disease treatment effect and preventing diseases are achieved.

Description

technical field [0001] The invention relates to the technical field of preparation of anticancer drugs, in particular to a method for preparing lipid derivatives targeting tumor tissues. Background technique [0002] Lipids are compounds that are insoluble in water and can be extracted by non-polar organic solvents such as ether, chloroform, and benzene. They mainly include esters and derivatives formed by the action of fatty acids and alcohols. Lipids include oils and lipids. Lipids are a class of small organic molecules in the body. It includes a wide range of substances. Their chemical structures are very different and their physiological functions are different. Their common physical properties are that they are insoluble in water but soluble in organic solvents. They can be dissolved in water Aggregates with each other to form internally hydrophobic aggregates. There are two main directions for the understanding of lipids. Lipids in food are more concerned in the field...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K45/00A61K47/24A61K47/28A61P35/00A61P37/04
CPCA61K9/1075A61K45/00A61K47/24A61K47/28A61P35/00A61P37/04
Inventor 钟天翼
Owner 苏州合疗生物技术有限公司
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