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Application of IGFL4 gene as marker in diagnosis and treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer

A technology for endometrial cancer and colorectal cancer, applied in the fields of molecular biology and tumor marker medicine, can solve problems such as unclear effects, achieve the goal of inhibiting tumor cell invasion, inhibiting cell proliferation, and increasing the level of apoptosis Effect

Pending Publication Date: 2021-07-16
THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its role in tumors is still unclear, and there is no relevant literature reporting the role of this gene. Finding effective early onset biomarkers and related molecular mechanisms can guide gastric cancer, colorectal cancer, endometrial cancer and Clinical diagnosis, treatment and prognosis of ovarian cancer are of great significance

Method used

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  • Application of IGFL4 gene as marker in diagnosis and treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer
  • Application of IGFL4 gene as marker in diagnosis and treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer
  • Application of IGFL4 gene as marker in diagnosis and treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer

Examples

Experimental program
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Effect test

Embodiment

[0038] Example IGFL4 gene expression in malignant tumors (including gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer) cell line and related cell function experimental testing method.

[0039] The source of cell lines involved in the examples: gastric cancer cell line (MGC-803, SGC7901), intestinal cancer cell line (HCT116, SW480, SW620), endometrial cancer cell line (H1C-1A, H1C-1B, Ishikuwa), Ovarian cancer cell line (A2780, CAOV3, OVCAR3, SKOV3, HO8910) Guangzhou Geni European Biotechnology Co., Ltd.

[0040] 1. IGFL4 mRNA levels in gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer cell line.

[0041] 1.1 Totto the total RNA of tumor cells by Trizol reagent, adding Trizol 1 / 5 volume of chloroform, strenuous oscillate for 15 seconds, after sufficiently emulsifying, at room temperature for 5 minutes; at 4 ° C, 12,000 g of centrifugation for 20 minutes, The supernatant is transferred to another new centrifuge tube, adding an equal volu...

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Abstract

The invention relates to the technical field of molecular biology and tumor marker medicine, in particular to application of an IGFL4 gene as a marker in diagnosis and treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer. The IGFL4 gene can be used as a diagnostic biomarker for gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer or can be used for preparing a cancer diagnosis product. The IGFL4 gene is specifically overexpressed in gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer, but there is no such specific high expression in normal tissues. By detecting IGFL4 gene expression in a subject, occurrence of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer can be quickly, accurately and clearly determined. The IGFL4 gene serves as a diagnostic marker of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer, provides a new target for clinical treatment of gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer, and can be applied to preparation of antitumor drugs.

Description

Technical field [0001] The present invention relates to the field of molecular biology and tumor marker medical technology, in particular to IGFL4 gene as a marker in gastric cancer, colorectal cancer, endometrial cancer and ovarian cancer. Background technique [0002] Gastric Carcinoma refers to an epithelial malignant tumor of the original body. The incidence of gastric cancer in my country is second only to the second place in lung cancer, and the mortality is ranked third. The world's annual new gastric cancer case is about 1.2 million, and 40% of China accounts for about 40%. my country's early gastric cancer is very low, only about 20%, most discovery is progressing period, and the overall 5 years of survival rate is less than 50%. In recent years, with the popularity of gastroscopy, the proportion of early gastric cancer has increased year by year. [0003] Colorectal cancer is one of the most common malignant tumors worldwide. In recent years, China's colorectal cancer i...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886A61K45/00A61P35/00
CPCC12Q1/6886A61K45/00A61P35/00C12Q2600/158
Inventor 赵杨陈说关雪江汝琪
Owner THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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