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Application of substance to preparation of product for treating primary dysmenorrhea

A primary dysmenorrhea, product technology, applied in the direction of drugs or prescriptions, can solve side effects, shorten the number of days of attack and other problems

Pending Publication Date: 2021-07-16
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

NSAIDs are mainly used to relieve pain symptoms during the onset of dysmenorrhea, and have no obvious effect on preventing the onset and shortening the duration of the onset, and long-term use can easily cause many adverse reactions such as gastrointestinal side effects

Method used

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  • Application of substance to preparation of product for treating primary dysmenorrhea
  • Application of substance to preparation of product for treating primary dysmenorrhea
  • Application of substance to preparation of product for treating primary dysmenorrhea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Calculation and prediction of the active substance in Guizhi Fuling Capsules for treating primary dysmenorrhea The treatment of primary dysmenorrhea is related to anti-inflammatory and analgesic effects. The present inventor identified the medicinal substances in Guizhi Fuling Capsules for treating primary dysmenorrhea through network pharmacology calculation and prediction, including the following steps:

[0038] 1. Collection of compounds in Guizhi Fuling Capsules

[0039] Guizhi Fuling Capsules contains 5 traditional Chinese medicines of Guizhi, Poria, Cortex Moutan, Radix Paeoniae Alba, and Peach Kernel. Some compounds reported in Guizhi Fuling Capsules were collected from the literature. The number of compounds contained in each traditional Chinese medicine is shown in Table 1.

[0040] Table 1. Compound information of traditional Chinese medicines contained in Guizhi Fuling Capsules

[0041] traditional Chinese medicine Number of compounds...

Embodiment 2

[0047] Example 2: Compounds in Guizhi Fuling Capsules Inhibit COX2 Enzyme Activity 1. Experimental Method

[0048] Seven substances that may interfere with COX2 (including gallic acid, ethyl gallate, galloyl paeoniflorin, 1,2,3,4,6-pentagalloyl glucose, paeonol, cinnamon aldehyde, cinnamon Acid), the present invention has carried out the experiment that above-mentioned compound inhibits COX2 enzymatic activity. The biological evaluation method based on fluorescence detection of human recombinant COX-2 enzyme activity was used to study the inhibition of COX2 activity of compounds in Guizhi Fuling Capsules. Experimental materials include 96-well cell plate (Corning3925black plate, black bottom), cyclooxygenase-2

[0049] (COX-2) Inhibitor Screening Kit, Biyuntian (Item No.S0168) and gallic acid (No. 307, gallic acid, 149-91-7), ethyl gallate (No. 442, ethyl gallate, 831 -61-8), galloyl paeoniflorin (Code: 443, galloylpaeoniflorin, 122965-41-7), 1,2,3,4,6-pentagalloyl glucose (...

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Abstract

The invention relates to application of a substance to preparation of a product for treating primary dysmenorrhea and application of the substance as a quality control marker of cassia twig and poria cocos capsules for treating primary dysmenorrhea. The substance comprises at least one of gallic acid, ethyl gallate, galloylpaeoniflorin and 1, 2, 3, 4, 6-pentagalloylglucose. The application comprises treatment of primary dysmenorrhea and quality control of the cassia twig and poria cocos capsule. The inventor carries out calculation, prediction and analysis through a network pharmacology method, and identifies a substance which can inhibit COX2 to play anti-inflammatory and analgesic effects and the like so as to treat primary dysmenorrhea in the cassia twig and poria cocos capsule, so that the substance can also be used as a quality control marker of the cassia twig and poria cocos capsule for intervening in COX2 to treat primary dysmenorrhea. In-vitro verification experiments show that the group of substances can inhibit COX2 enzyme activity.

Description

technical field [0001] The invention relates to a material used as a product for treating primary dysmenorrhea and as a quality control marker for Guizhi Fuling capsules for treating primary dysmenorrhea. Background technique [0002] Primary dysmenorrhea (Primary Dysmenorrhea, PD) refers to a kind of functional dysmenorrhea caused by non-genital organic diseases, which seriously affects the normal work and quality of life of patients. [1] . At present, conventional doses of nonsteroidal anti-inflammatory drugs (NSAIDs) are given as the first-line drugs for the treatment of primary dysmenorrhea. NSAIDs reduce the synthesis of prostaglandins (PGs) by inhibiting cyclooxygenase (COX), thereby reducing the uterine spasmodic contraction caused by PGs, so as to achieve the purpose of treating dysmenorrhea. [2] . Among them, cyclooxygenase 2 (cyclooxygenase 2, COX2) is the main intervention target of first-line drugs for the treatment of primary dysmenorrhea. NSAIDs are mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10
CPCG16H20/10
Inventor 李梢肖伟张斯琴王振中赖新星曹亮
Owner JIANGSU KANION PHARMA CO LTD
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