Application of substance to preparation of product for treating primary dysmenorrhea
A primary dysmenorrhea, product technology, applied in the direction of drugs or prescriptions, can solve side effects, shorten the number of days of attack and other problems
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Embodiment 1
[0037] Example 1: Calculation and prediction of the active substance in Guizhi Fuling Capsules for treating primary dysmenorrhea The treatment of primary dysmenorrhea is related to anti-inflammatory and analgesic effects. The present inventor identified the medicinal substances in Guizhi Fuling Capsules for treating primary dysmenorrhea through network pharmacology calculation and prediction, including the following steps:
[0038] 1. Collection of compounds in Guizhi Fuling Capsules
[0039] Guizhi Fuling Capsules contains 5 traditional Chinese medicines of Guizhi, Poria, Cortex Moutan, Radix Paeoniae Alba, and Peach Kernel. Some compounds reported in Guizhi Fuling Capsules were collected from the literature. The number of compounds contained in each traditional Chinese medicine is shown in Table 1.
[0040] Table 1. Compound information of traditional Chinese medicines contained in Guizhi Fuling Capsules
[0041] traditional Chinese medicine Number of compounds...
Embodiment 2
[0047] Example 2: Compounds in Guizhi Fuling Capsules Inhibit COX2 Enzyme Activity 1. Experimental Method
[0048] Seven substances that may interfere with COX2 (including gallic acid, ethyl gallate, galloyl paeoniflorin, 1,2,3,4,6-pentagalloyl glucose, paeonol, cinnamon aldehyde, cinnamon Acid), the present invention has carried out the experiment that above-mentioned compound inhibits COX2 enzymatic activity. The biological evaluation method based on fluorescence detection of human recombinant COX-2 enzyme activity was used to study the inhibition of COX2 activity of compounds in Guizhi Fuling Capsules. Experimental materials include 96-well cell plate (Corning3925black plate, black bottom), cyclooxygenase-2
[0049] (COX-2) Inhibitor Screening Kit, Biyuntian (Item No.S0168) and gallic acid (No. 307, gallic acid, 149-91-7), ethyl gallate (No. 442, ethyl gallate, 831 -61-8), galloyl paeoniflorin (Code: 443, galloylpaeoniflorin, 122965-41-7), 1,2,3,4,6-pentagalloyl glucose (...
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