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Artificial blood vessel and preparation method thereof

A technology of artificial blood vessels and catheters, applied in the field of artificial blood vessels and its preparation, to achieve the effects of improving biocompatibility, good stability, and promoting cell recruitment

Pending Publication Date: 2021-09-28
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is: how to ensure the long-term patency of the artificial blood vessel

Method used

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  • Artificial blood vessel and preparation method thereof
  • Artificial blood vessel and preparation method thereof
  • Artificial blood vessel and preparation method thereof

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Embodiment Construction

[0036] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0037] The inventive concept of the present application is as follows: In view of the problems that the artificial blood vessels in the prior art are prone to postoperative coagulation, inflammation, cell recruitment, matrix precipitation and vascular remodeling, the present application uses drugs with different functions to modify the surface of artificial blood vessels , Forming drug coatings with different functions on the surface of artificial blood vessels in advance, so that different concentrations of drugs can be released within a certain period of time to achieve anticoagulation and avoi...

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Abstract

The invention discloses an artificial blood vessel and a preparation method thereof. The preparation method comprises the following steps: preparing a catheter substrate, wherein the surface of the catheter substrate is provided with charges; preparing a first drug solution and a second drug solution, wherein the charges carried by the first drug solution and the second drug solution are different in electrical property, and the charges carried by the first drug solution and the charges carried by the catheter substrate are different in electrical property; and sequentially and alternately soaking the catheter substrate in the first drug solution and the second drug solution, so that a drug coating is formed on the surface of the catheter substrate. The charges carried by the surface of the catheter substrate are fully utilized, so that layer-by-layer self-assembly of two-component drugs with different charges on the surface of the substrate is realized; and after the blood vessel is implanted, due to sequential release of two drugs with different functions, the drug functions are exerted in different time periods, and the synergistic effect of the two drugs is achieved, so that improvement of long-term smoothness of the artificial blood vessel is ensured, and regeneration and reconstruction of the blood vessel are promoted.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an artificial blood vessel and a preparation method thereof. Background technique [0002] Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide, accounting for nearly 20 million deaths each year. According to statistics, there are more than 80,000 heart valve replacements and 600,000 blood vessel transplants in the United States every year, with a total expenditure of nearly 200 billion US dollars. The prevalence of cardiovascular disease risk factors in my country is obvious, leading to an increase in the number of cardiovascular disease incidence. Overall, the prevalence and mortality of cardiovascular diseases in my country are still on the rise, and the mortality rate of cardiovascular diseases ranks first, higher than that of tumors and other diseases, accounting for more than 40% of residents' deaths from diseases. ...

Claims

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Application Information

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IPC IPC(8): A61L27/28A61L27/20A61L27/18A61L27/50A61L27/54A61F2/06
CPCA61L27/28A61L27/20A61L27/18A61L27/50A61L27/54A61F2/06A61F2240/001A61L2300/42A61L2300/41A61L2300/236A61L2300/252A61L2300/43A61L2300/412A61L2400/18A61L2420/02A61L2300/602A61L2420/06A61L2420/08C08L5/04C08L77/04
Inventor 阮长顺曾志文梁青飞吴明明吕维加
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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