A kind of small size calcium phosphate fiber and its preparation method and application

Abstract

The invention discloses a small-sized calcium phosphate fiber, a preparation method thereof, and an application in the preparation of a medicament for repairing fractures. The preparation method includes: completely dissolving polyvinyl alcohol in deionized water at 90-100 DEG C, and then cooling to normal temperature to obtain solution A, the mass concentration of polyvinyl alcohol in solution A is 0.5%-1%; Amorphous calcium phosphate is dispersed in absolute ethanol to obtain mixed solution B. The concentration of calcium phosphate in mixed solution B is 5-20 mg / mL; arginine is dissolved in deionized water at room temperature to obtain solution C. The mass concentration of the amino acid is 0.5% to 3%; under stirring, the mixed solution B and solution C are added dropwise to the solution A and evenly mixed, after the dropwise addition is completed, ultrasonic for 20 to 40 minutes, and finally air-dried at room temperature to form a thin film Twist and twist to obtain calcium phosphate fibers of small size; the volume ratio of mixed solution B, solution C, and solution A is 1:1:1.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a small-sized calcium phosphate fiber and a preparation method and application thereof. Background technique [0002] Fracture refers to a typical disease in which the integrity and continuity of bone or cartilage tissue is interrupted when bone or cartilage tissue is subjected to violence, resulting in bone dysfunction. Severe fractures can lead to complications such as shock and can even be life-threatening. [0003] If the fracture occurs due to mild external impact due to the disease of the bone itself, such as tuberculosis, osteomyelitis or osteoma, it is called a pathological fracture. Fractures mostly occur in children and the elderly, with a lower incidence in young and middle-aged people. [0004] The main methods of treating fractures are: open reduction and bone fixation. These two are the more commonly used means of clinical treatment of fractures. But they al...

AI Technical Summary

Problems solved by technology

But they also have disadvantages: such as pain for the patient, and the possibility of recurrence when the fixation falls off, thereby increasing financial revenue and expenditure

Commonly used calcium phosphate-based repair materials are mainly crystalline hydroxyapatite, which is large in size and cannot be used to repair fractures from the root

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