Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker

A serum marker, combined detection technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of research, low sensitivity and specificity, etc.

Pending Publication Date: 2021-11-23
ZHENGZHOU UNIV
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, carcinoembryonic antigen (CEA) as a traditional serum tumor marker is widely used in the auxiliary diagnosis of lung cancer, but the single detection still has the disadvantages of low sensitivity and specificity.
As the first type of antibody produced in the humoral immune response, IgM autoantibodies have great potential as an early diagnostic indicator for lung cancer, but there is no relevant research yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker
  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker
  • Joint detection serum marker for early diagnosis of lung adenocarcinoma and application of joint detection serum marker

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0034] 1. Collection and preparation of serum samples

[0035] 1.1 Collection of serum samples

[0036] A total of 430 subjects were included in this study, which were divided into discovery group and verification group. The discovery group was used to screen the IgM autoantibody indicators with high diagnostic value for lung adenocarcinoma. The verification group was used to verify the candidate IgM autoantibody indicators, and combined with CEA to build a diagnostic model.

[0037] The serum samples of all subjects were collected in a tertiary hospital in Henan Province from 2016 to 2019. The basic information, pathological stage and serum CEA level of all subjects were obtained with the consent of the patients and the approval of the Institutional Review Board and the Hospital Ethics Committee In some cases, it is summarized and sorted through the internal system of the hospital. Among them, the test results of serum CEA were provided by the laboratory department of the h...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a joint detection serum marker for early diagnosis of lung adenocarcinoma, comprising IgM autoantibodies of TSHR, ERBB2, Survivin, PIK3CA and JAK2. An ELISA serum detection kit is prepared by using a specific protein corresponding to the joint detection serum marker. The joint detection serum marker plays an important role in improving the sensitivity, specificity and accuracy of early diagnosis of lung adenocarcinoma. Meanwhile, the joint detection serum marker is combined with a CEA serum marker to construct a diagnosis model, and a serological detection method which is high in sensitivity, strong in specificity, low in cost and capable of assisting clinical diagnosis of lung adenocarcinoma is provided.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a combined detection serum marker that can be used for early diagnosis of lung adenocarcinoma and its application. Background technique [0002] In 2020, according to statistics, there will be 2.2 million new cases of lung cancer and 1.8 million deaths, accounting for 11.4% and 18.0% of all cancers respectively. It is the second most common cancer in the world with the highest mortality rate. Lung adenocarcinoma, as the most common histological subtype of non-small cell lung cancer, accounts for about 40% of lung malignancies, and mostly occurs in women and non-smokers. A large number of studies have shown that the 5-year disease-free survival rate of patients with adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) can be close to 100% if they undergo radical surgery. It can be seen that early diagnosis and timely and effective trea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/543
CPCG01N33/57423G01N33/57488G01N33/54313
Inventor 代丽萍张建营张雪王雨林王晓欧阳松云赵春玲
Owner ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap