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Method and apparatus for multimodal or multiplexed electrical modulation of pain using composite electromagnetic fields

An electromagnetic, electrode-based technology for multimodal or multiplexed electrical modulation of pain and devices using complex electromagnetic fields that can address under-understood issues

Pending Publication Date: 2021-12-10
美敦力SG有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The concept behind tonic SCS is to block, or "close the gate on," the pain signal traveling to the brain by the paresthesia induced by the applied varying electric field, however, the frequency, waveform shape, amplitude and pulse width are related to the sedation by which SCS provides sedation. The relationship between the mechanisms of pain effects is not well understood

Method used

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  • Method and apparatus for multimodal or multiplexed electrical modulation of pain using composite electromagnetic fields
  • Method and apparatus for multimodal or multiplexed electrical modulation of pain using composite electromagnetic fields
  • Method and apparatus for multimodal or multiplexed electrical modulation of pain using composite electromagnetic fields

Examples

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example 1

[0175] refer to Figure 15, an initial pilot study (n=29) using an animal model of neuropathic chronic pain was performed. In this study, peripheral nerve injury was surgically induced by transection of the tibial and fibular branches of the sciatic nerve at the trifurcation point while preserving the sural nerve (SNI model of preserved nerve injury). Four days after transection, subjects developed mechanical and thermal hypersensitivity (allodynia), which was seen as pain-like behavior. Subjects were implanted at the vertebral level corresponding to the innervation of the sciatic nerve with a small cylindrical four-contact lead surgically fitted into the subject's epidural space. On the fourth postoperative day, subjects were subjected to behavioral testing using von Frey filaments. These filaments, with varying tensile strengths, were used to measure the sensitivity to mechanical stimuli in areas of the skin affected by nerve damage. In the SNI model, the plantar region o...

example 2

[0179] In the Examples, the genome-wide expression effect in ipsilateral dorsal cord (DC) tissue of spinal cord stimulation (administered for up to 72 hours) was assessed in rats induced by chronic neuropathic pain following peripheral nerve injury. Specifically, in the example, genome-wide expression levels were compared between animals in one of the most commonly used rodent models of chronic neuropathic pain (sparing nerve injury, SNI) for serial SCS animals and sham-treated animals , the sham-treated animals are animals in which the pain model is induced and it is implanted but not stimulated.

[0180] Commercially available genome-wide expression profiling microarrays of laboratory rats employed in the current study were able to survey the expression of approximately 21,000 genes. Enrichment analysis based on cluster statistics (using Weighted Gene Correlation Network Analysis (WGCNA)) allows the identification of modules (or subsets) comprising genes that are highly corr...

example 3

[0197] The effect of phase polarity on previously proposed gene modulation was performed using an animal model of chronic neuropathic pain. In this example, spinal cord tissue was obtained from an animal and stimulated using a rectangular waveform with a frequency of 50 Hz per phase and a pulse width of 200 μs, which could be monophasic cathodic, monophasic anodal, or with an initial cathodic Symmetrical duplex of polarity. RNA was extracted from tissues and cDNA was prepared by reverse transcription. RNA expression levels were assessed using real-time PCR, and levels were quantified and normalized. Based on the experiments described above (Example 2), the selection included markers for glial activation (tlr2, cxcl16), markers for calcium-dependent glial processes (Cabp1), markers for immune system activation (cd68 ) and a panel of opioid receptor (oprm1) genes for analysis.

[0198] Figures 17A-17E A graph conceptually illustrating the observed expression levels of selec...

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Abstract

Apparatus and methods for managing pain use a multiplexed / multimodal modulation / stimulation signal to provide pain relief during spinal cord stimulation or peripheral nerve stimulation. A glial stimulation signal is provided to a first subgroup of the electrodes and simultaneously a neuronal stimulation signal is provided to a second subgroup of the electrodes. At least one of the glial stimulation and neuronal stimulation electric signals comprises a plurality of component signals multiplexed to the respective electrode array to which the glial stimulation and neuronal stimulation signals are provided.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 843,757, filed May 6, 2019, and entitled "Methods and Apparatus for Modulating Cellular Activity in Neural Tissue Using Multiplexed Electrical Signals About Differential Targets" right and interest, the entire contents of said US Provisional Application are specifically incorporated herein by reference. [0003] This application also claims priority and benefit to U.S. Provisional Application No. 62 / 964,281, filed January 22, 2020, and entitled "Method and Apparatus for Multimodal Electrical Modulation of Pain Using Composite Electromagnetic Fields," said U.S. The entire content of the provisional application is specifically incorporated herein by reference. technical field [0004] The present disclosure relates to systems and methods for providing multimodal or multiplexed stimulation to neural structures, and more particularly, to systems for co...

Claims

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Application Information

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IPC IPC(8): A61N1/36
CPCA61N1/36062A61N1/36071A61N1/36146A61N1/36171A61N1/36175A61N1/36192A61N1/36196A61N1/36185A61N1/0551A61N1/36132A61N1/36178A61N2/006A61N2/02
Inventor R·瓦列霍D·L·塞德诺N·A·托格森B·A·史密斯
Owner 美敦力SG有限责任公司
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