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Establishment method of cynomolgus monkey hypertriglyceridemia model and application of method

A technology for hypertriglyceridemia and a method for establishing a method, which can be used in pharmaceutical formulations, preparations for in vivo experiments, compound screening/testing, etc. Problems such as mildew and deterioration, to avoid poor palatability and avoid serious defects

Inactive Publication Date: 2021-12-17
湖北天勤生物技术研究院有限公司
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  • Application Information

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Problems solved by technology

However, high-fat feed is greasy and has poor palatability. Rodents can still eat high-fat feed, but animals do not like to eat it due to insufficient hardness of the feed, and high-fat feed has high storage conditions in long-term experiments, otherwise it is easy to mold and deteriorate

Method used

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  • Establishment method of cynomolgus monkey hypertriglyceridemia model and application of method
  • Establishment method of cynomolgus monkey hypertriglyceridemia model and application of method
  • Establishment method of cynomolgus monkey hypertriglyceridemia model and application of method

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Embodiment 1

[0070] (1) Select 31 male cynomolgus monkeys aged 12-21; among them, the cynomolgus monkeys all come from Hubei Tianqin Biotechnology Co., Ltd., and the procurement procedure complies with the laws and regulations of the People’s Republic of China, approved by the Forestry Department of Hubei Province , Approved by the Forestry Department of Guangdong Province. All the experimental monkeys passed the physical examination, and all indicators met the local inspection and quarantine standards.

[0071] (2)(2) Feed the cynomolgus monkeys in step (1) four times a day, 7:30-8:00 for the first feeding with 120 grams of sugary feed, and 12:00-12:30 for the second feeding Supplementary food 30 grams of brown sugar or 25 grams of biscuits, alternate feeding of brown sugar and biscuits every three days, 14:00-14:30 for the third feeding of 100 grams of green material, 17:00-17:30 for the fourth feeding 120 grams of sugar-containing feed, all the feeds can be eaten up, wherein the sugar-...

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Abstract

The invention relates to the technical field of non-human primate experimental animal disease models, and discloses an establishment method of a cynomolgus monkey hypertriglyceridemia model and application of the method. The method comprises the following steps: (1) selecting male cynomolgus monkeys of which the age is 12-21 years old; (2) feeding for four times every day, namely feeding sugar-containing feed for the first time, feeding complementary food for the second time, feeding green feed for the third time and feeding sugar-containing feed for the fourth time; (3) after the cynomolgus monkeys are fed for one year according to the mode in the step (2), detecting corresponding indexes, and screening out the cynomolgus monkeys of which the serum triglyceride level is greater than 1.14 mmol/L in an empty stomach state; wherein during feeding with the complementary food, the cynomolgus monkeys are alternately fed with brown sugar blocks and biscuits, and the complementary food is alternately used for feeding once every three days; the sugar-containing feed is obtained by mixing conventional feed and brown sugar. According to the method, the cynomolgus monkey hypertriglyceridemia model is successfully established by adopting mild long-term high-glucose and high-fat feeding, and the cynomolgus monkey hypertriglyceridemia model can be used for efficacy evaluation in the research and development process of new drugs.

Description

technical field [0001] The invention relates to the technical field of non-human primate experimental animal disease models, in particular to a method for establishing a cynomolgus monkey hypertriglyceridemia model and its application. Background technique [0002] Hyperlipidemia refers to a disease in which one or more lipids in plasma are higher than normal caused by abnormal fat metabolism or transport. It has a high clinical incidence and is often divided into hypercholesterolemia (TC) (TG) hyperlipidemia and mixed hyperlipidemia (that is, high TG and high TC hyperlipidemia at the same time). Among them, hypertriglyceridemia is a heterogeneous triglyceride protein synthesis or degradation disorder. It is one of the most common lipid abnormalities in clinical practice, especially in patients with metabolic syndrome or type 2 diabetes. The consequence of high triglycerides is that it is easy to cause "thick blood", that is, blood viscosity caused by excessive lipid conte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61K49/00
CPCA01K67/02A61K49/0008
Inventor 贺烽王建枝李高胥绍祥张树林冉德友
Owner 湖北天勤生物技术研究院有限公司
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