Establishment method and application of cynomolgus monkey obesity model

A method for establishing an obesity model, which is applied in the field of establishing a cynomolgus monkey obesity model, can solve the problems such as the lack of a clear report on the diagnostic criteria of the cynomolgus monkey obesity model and the discomfort of the cynomolgus monkey, so as to avoid animal anorexia and avoid injury. Effect

Active Publication Date: 2021-12-21
湖北天勤生物技术研究院有限公司
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Problems solved by technology

However, the size of cynomolgus monkeys is significantly smaller than that of rhesus monkeys, and the diagnostic criteria of the obesity rhesus monkey model are not suitable for cynomolgus monkeys
At present, there is no clear report on the diagnostic criteria of the cynomolgus monkey obesity model

Method used

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  • Establishment method and application of cynomolgus monkey obesity model
  • Establishment method and application of cynomolgus monkey obesity model
  • Establishment method and application of cynomolgus monkey obesity model

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Embodiment 1

[0066] (1) Select 31 male cynomolgus monkeys aged 12-21; among them, the cynomolgus monkeys all come from Hubei Tianqin Biotechnology Co., Ltd., and the procurement procedure complies with the laws and regulations of the People’s Republic of China, approved by the Forestry Department of Hubei Province , Approved by the Forestry Department of Guangdong Province. All the experimental monkeys passed the physical examination, and all indicators met the local inspection and quarantine standards.

[0067] (2) Feed the cynomolgus monkeys in step (1) four times a day, 120 grams of sugar-containing feed for the first time at 7:30-8:00, and brown sugar cubes for the second time at 12:00-12:30 30 grams or 25 grams of biscuits, brown sugar cubes and biscuits are fed alternately every three days, 14:00-14:30 for the third feeding of green material 100 grams, 17:00-17:30 for the fourth feeding of sugary feed 120 grams, and all the feeds can be eaten completely; wherein the sugar-containing...

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Abstract

The invention relates to the technical field of non-human primate experimental animal disease models, in particular to an establishment method and application of a cynomolgus monkey obesity model. The method comprises the following steps: (1) selecting male cynomolgus monkeys of which the age is 12-21 years old; (2) feeding for four times every day, wherein feeding with sugar-containing feed for the first time, feeding with complementary food for the second time, feeding with green feed for the third time and feeding with the sugar-containing feed for the fourth time; (3) after the cynomolgus monkeys are fed for one year according to the mode in the step (2), detecting corresponding indexes, and screening out the cynomolgus monkeys with the BMI larger than 16.95 kg/m < 2 >, the body weight larger than 9.3 kg and the waistline larger than 45 cm, wherein during feeding with the complementary food, the cynomolgus monkeys are alternately fed with brown sugar blocks and biscuits, and feeding is alternately performed once every three days; the sugar-containing feed is obtained by mixing conventional feed and brown sugar. According to the method, the obesity cynomolgus monkey model is successfully established in a mild feeding mode, and the method can be used for drug effect evaluation in the research and development process of obesity new drugs.

Description

technical field [0001] The invention relates to the technical field of non-human primate experimental animal disease models, in particular to a method for establishing a cynomolgus monkey obesity model and its application. Background technique [0002] Obesity refers to excessive total body fat content and / or increased local content and abnormal distribution. It is a chronic metabolic disease caused by genetic and environmental factors. Clinically, body mass index (BMI) is used as a common simple indicator for judging obesity. According to the standards of "Guidelines for the Prevention and Control of Overweight and Obesity in Chinese Adults", BMI (kg / m 2 )≥28.0 is diagnosed as obesity. The etiology of obesity is complex, which is the result of the interaction of multiple factors such as genetic factors and environmental factors. According to the pathogenesis and etiology, obesity can be divided into simple and secondary two categories. Simple obesity can be further divi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A23K50/00A23K20/163A23K10/30A23K10/37A23K10/22A23K20/158A23K20/22A23K20/20
CPCA01K67/02A23K50/00A23K20/163A23K10/30A23K10/37A23K10/22A23K20/158A23K20/22A23K20/20A01K2267/03Y02P60/87
Inventor 贺烽王建枝李高胥绍祥张树林冉德友
Owner 湖北天勤生物技术研究院有限公司
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