Antibacterial coating with ph response function, functional material with antibacterial coating and preparation method thereof

A technology of antibacterial coating and functional material, which is applied in the field of functional material of antibacterial coating and its preparation, can solve the problems of reducing bactericidal effect, inflammation and immune response, and high biological toxicity, and achieve good biocompatibility, reduce cell Toxicity, effect of firm coating

Active Publication Date: 2022-08-02
WEIGAO HLDG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Actively attacking surfaces often suffers from problems related to the accumulation of dead bacteria and debris, which not only shields functional groups, thereby reducing the bactericidal effect, but also acts as a conditioning film to provide nutrients for subsequent bacterial adhesion, resulting in an immune response or inflammation
At the same time, the biological toxicity is high, and it is easy to cause inflammation and immune response in the body

Method used

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  • Antibacterial coating with ph response function, functional material with antibacterial coating and preparation method thereof
  • Antibacterial coating with ph response function, functional material with antibacterial coating and preparation method thereof
  • Antibacterial coating with ph response function, functional material with antibacterial coating and preparation method thereof

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preparation example Construction

[0133] The present invention provides a method for preparing a functional material with an antibacterial coating according to any one of the above technical solutions, characterized in that it includes the following steps:

[0134] 1) The monomer with R structure, with R 1 After the monomer of the structure and the first solvent are reacted, the first polymer intermediate is obtained after precipitation;

[0135] 2) the first polymer intermediate obtained by the above steps, having R 2 Monomer halogenated alkyl of X structure, with R 3 After the X-structured alkyl halide reacts with the first solvent again, the second polymer intermediate is obtained after precipitation; wherein, X is selected from Cl, Br or I;

[0136] 3) after carrying out the deprotection reaction of the second polymer intermediate, trifluoroacetic acid and the second solvent obtained in the above steps, the third polymer intermediate is obtained;

[0137] 4) the third polymer intermediate, concrete R obta...

Embodiment 1

[0177] Preparation of Adaptive Medical Antimicrobial Catheter:

[0178] (1) Preparation of zwitterionic polymer:

[0179] Take 0.52g of ethylene glycol glycidyl ether and 0.64g of N-tert-butoxycarbonylethylenediamine in dimethyl sulfoxide as solvent at 60°C for 8h, then the ether precipitates, and after vacuum drying for 24h, take 500mg and 1mL of bromohexane and 100mg 3-bromobenzophenone was reacted in dimethyl sulfoxide solvent at 45°C for 24h. After the reaction, ether was precipitated and dried in vacuo. Finally, 500mg of the product was dissolved in 10mL of dichloromethane, and 3mL of trifluoroacetic acid was added and stirred at 25°C. 8h to remove the protecting group, and finally 500mg of the deprotected polymer was dissolved in 20mL of N,N-dimethylformamide solution, 100mg of maleic anhydride was added, magnetic stirring at 50°C for 24h, and dialyzed in a 3500Da dialysis bag for 24h , resulting in a zwitterionic polymer.

[0180] (2) Preparation of coating liquid:

...

Embodiment 2

[0185] (1) Preparation of zwitterionic polymer:

[0186] Take 0.48g of diglycidyl ether and 0.71g of N-tert-butoxycarbonyl-1,3-propanediamine in N,N-dimethylacetamide at 80°C for 6h, then react with ether for 6h, vacuum dry for 24h and take 500mg of 1.2 mL of bromododecane and 85 mg of 4-bromobenzoyl benzene were reacted in N,N-dimethylacetamide at 50°C for 24 h. After the reaction, n-hexane was precipitated and dried in vacuo. Finally, 500 mg of the product was dissolved in 10 mL of dimethylacetamide. Chloromethane, add 2.2 mL of trifluoroacetic acid, and stir at room temperature for 12 h to remove the protective group. Finally, 500 mg of the deprotected polymer was dissolved in 20 mL of dimethyl sulfoxide solution, and 2,3-dimethylmaleate was added. Acid anhydride 115mg, magnetic stirring at 55°C for 24h, dialysis in a 3500Da dialysis bag for 24h, to obtain a zwitterionic polymer. .

[0187] (2) Preparation of coating liquid:

[0188] Take 1 g of the polymer obtained in s...

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Abstract

The present invention provides an antibacterial coating comprising a zwitterionic polymer having a structure represented by formula (I). The polymer designed by the present invention has pH-responsive functional groups. In an acidified environment caused by bacteria, the structure of the responsive functional groups changes to remove negatively charged groups. At this time, the polymer exhibits positive charge and the polymer exhibits antibacterial properties. Bacterial microenvironment effectively sterilizes. In addition, the introduction of benzophenone derivatives on the polymer as a photocurable or cross-linking group can realize the firm coating of the polymer on the surface of the medical device. The self-adaptive antibacterial coating provided by the present invention combines photocurable groups with zwitterionic groups to construct a zwitterionic polymer, and realizes dual functions of anti-adhesion and responsive antibacterial through this polymer. Moreover, the preparation process is simpler, the equipment requirement is low, the operation is easy, and the feasibility is high.

Description

technical field [0001] The invention belongs to the field of antibacterial medical devices, relates to an antibacterial coating, a functional material with an antibacterial coating and a preparation method thereof, and in particular relates to an antibacterial coating with a pH response function and the function of the antibacterial coating with a pH response function Materials and methods for their preparation. Background technique [0002] Bacteria are ubiquitous in the environment and in the human body, and pathogenic bacteria that cause human disease can pose a serious threat to public health. The most common bacterial-derived diseases are foodborne diseases, urinary tract infections, infectious sexually transmitted and nosocomial infections. The adhesion, growth and reproduction of bacteria on the surface of the material, and even the formation of biofilms are the main reasons for the failure of medical material implantation. Similarly, the adhesion, proliferation and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D179/02C09D5/14C08G73/02A61L29/08A61L29/14
CPCC09D179/02C09D5/14C08G73/024A61L29/085A61L29/14A61L2400/18A61L2420/02
Inventor 闫顺杰张桢焱周容涛栾世方万雪孙振龙张帅殷敬华
Owner WEIGAO HLDG
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