Application of radix angelicae dahuricae extract in aspect of regulating climacteric dyslipidemia

A kind of Angelica dahurica extract and technology for dyslipidemia, which is applied in the application field of Angelica Root extract in regulating dyslipidemia in menopause

Pending Publication Date: 2022-01-25
SHAANXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Hormone replacement therapy (HRT) is a traditional treatment for menopausal metabolic syndrome, however, it also has certain limitations and side effects

Method used

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  • Application of radix angelicae dahuricae extract in aspect of regulating climacteric dyslipidemia
  • Application of radix angelicae dahuricae extract in aspect of regulating climacteric dyslipidemia
  • Application of radix angelicae dahuricae extract in aspect of regulating climacteric dyslipidemia

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Experimental program
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Embodiment

[0038] Materials and methods

[0039] 1.1 Reagents and materials

[0040] Short-chain fatty acids (acetic acid, propionic acid, butyric acid, valeric acid, isobutyric acid, isovaleric acid, and hexanoic acid) and 2-ethylbutyric acid (internal standard, IS) were purchased from Sigma Aldrich (Poole, Dorset, UK) . Angelica ( RAD ) medicinal materials, provided by Shaanxi Xingshengde Pharmaceutical Co., Ltd. All organic reagents were chromatography grade. Ultrapure water was prepared by a Milli-Q Integral 5 ultrapure water integrated intelligent system (Millipore, Bedford, MA, USA).

[0041] Preparation of Radix Angelicae Radix Extract

[0042] Take 2.5 kg of decoction pieces of Angelica dahurica, crush them, and ultrasonically extract them with 80% ethanol (1:10, w:v) for three times, half an hour each time, filter under reduced pressure to obtain the extract, and condense by rotary evaporation into a brown extract (about 202 g ). Take an appropriate amount of Angelica da...

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Abstract

The invention relates to the field of medicine preparation, in particular to application of a radix angelicae dahuricae extract in the aspect of regulating climacteric dyslipidemia. Through exploration, the inventor finds that the angelica dahurica extract can be used for regulating climacteric dyslipidemia, and a new medicament is provided for lipid metabolism disorder caused by estrogen deficiency. Specifically, the radix angelicae dahuricae extract can significantly up-regulate gene expression of HMG-CoA reductase (HMGCR) and cytochrome P450 7A1(CYP7A1) in intestinal liver circulation, and regulate gene expression of related receptors and proteins. The radix angelicae dahuricae extract can reduce the levels of total cholesterol (TC) and triglyceride (TG) of serum and liver, and can relieve fatty degeneration and inflammation of the liver. The radix angelicae dahuricae extract can remarkably regulate the composition of OVX intestinal microorganisms, remarkably improve the activity of bile salt hydrolase (BSH) and reconstruct an SCFA spectrum and a cholic acid metabolic spectrum.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to the application of the extract of Angelica dahurica in regulating climacteric dyslipidemia. Background technique [0002] Dyslipidemia and inflammation are key features of the metabolic syndrome of menopause. Studies of menopause in humans and reproductive aging in rodents have shown that decreased estrogen levels in the body and atrophy of reproductive organs can lead to lipid metabolism disorders, increasing the incidence of obesity and cardiovascular disease. The clinical manifestations of menopausal lipid metabolism disorders are mainly abdominal fat accumulation and elevated levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). Estrogen and other sex steroid hormones are also closely related to the regulation of inflammation. Menopause and the loss of estrogen can lead to increased levels of inflammation. The consumption ...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61P3/06A61P15/12A61K125/00
CPCA61K36/232A61P3/06A61P15/12
Inventor 陈琳
Owner SHAANXI UNIV OF CHINESE MEDICINE
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